Epigenetic Aging Mediates the Association between Pain Impact and Brain Aging in Middle to Older Age Individuals with Knee Pain
Chronic musculoskeletal pain is a health burden that may accelerate the aging process. Accelerated brain aging and epigenetic aging have separately been observed in those with chronic pain. However, it is unknown whether these biological markers of aging are associated with each other in those with...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Epigenetics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/15592294.2022.2111752 |
| _version_ | 1827811489290911744 |
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| author | Jessica A. Peterson Larissa J. Strath Chavier Laffitte Nodarse Asha Rani Zhiguang Huo Lingsong Meng Sean Yoder James H. Cole Thomas C. Foster Roger B. Fillingim Yenisel Cruz-Almeida |
| author_facet | Jessica A. Peterson Larissa J. Strath Chavier Laffitte Nodarse Asha Rani Zhiguang Huo Lingsong Meng Sean Yoder James H. Cole Thomas C. Foster Roger B. Fillingim Yenisel Cruz-Almeida |
| author_sort | Jessica A. Peterson |
| collection | DOAJ |
| description | Chronic musculoskeletal pain is a health burden that may accelerate the aging process. Accelerated brain aging and epigenetic aging have separately been observed in those with chronic pain. However, it is unknown whether these biological markers of aging are associated with each other in those with chronic pain. We aimed to explore the association of epigenetic aging and brain aging in middle-to-older age individuals with varying degrees of knee pain. Participants (57.91 ± 8.04 y) with low impact knee pain (n = 95), high impact knee pain (n = 53), and pain-free controls (n = 26) completed self-reported pain, a blood draw, and an MRI scan. We used an epigenetic clock previously associated with knee pain (DNAmGrimAge), the subsequent difference of predicted epigenetic and brain age from chronological age (DNAmGrimAge-Difference and Brain-PAD, respectively). There was a significant main effect for pain impact group (F (2,167) = 3.847, P = 0.023, $${\rm{ }}\eta _p^2$$ = 0.038, ANCOVA) on Brain-PAD and DNAmGrimAge-difference (F (2,167) = 6.800, P = 0.001, $${\rm{ }}\eta _p^2$$ = 0.075, ANCOVA) after controlling for covariates. DNAmGrimAge-Difference and Brain-PAD were modestly correlated (r =0.198; P =0.010). Exploratory analysis revealed that DNAmGrimAge-difference mediated GCPS pain impact, GCPS pain severity, and pain-related disability scores on Brain-PAD. Based upon the current study findings, we suggest that pain could be a driver for accelerated brain aging via epigenome interactions. |
| first_indexed | 2024-03-11T23:05:47Z |
| format | Article |
| id | doaj.art-aae0aa138060444e9da2fe3e33601a46 |
| institution | Directory Open Access Journal |
| issn | 1559-2294 1559-2308 |
| language | English |
| last_indexed | 2024-03-11T23:05:47Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Epigenetics |
| spelling | doaj.art-aae0aa138060444e9da2fe3e33601a462023-09-21T13:23:12ZengTaylor & Francis GroupEpigenetics1559-22941559-23082022-12-0117132178218710.1080/15592294.2022.21117522111752Epigenetic Aging Mediates the Association between Pain Impact and Brain Aging in Middle to Older Age Individuals with Knee PainJessica A. Peterson0Larissa J. Strath1Chavier Laffitte Nodarse2Asha Rani3Zhiguang Huo4Lingsong Meng5Sean Yoder6James H. Cole7Thomas C. Foster8Roger B. Fillingim9Yenisel Cruz-Almeida10University of FloridaUniversity of FloridaUniversity of FloridaMcKnight Brain InstituteUniversity of FloridaUniversity of FloridaMoffit Cancer CenterUniversity College LondonUniversity of FloridaUniversity of FloridaUniversity of FloridaChronic musculoskeletal pain is a health burden that may accelerate the aging process. Accelerated brain aging and epigenetic aging have separately been observed in those with chronic pain. However, it is unknown whether these biological markers of aging are associated with each other in those with chronic pain. We aimed to explore the association of epigenetic aging and brain aging in middle-to-older age individuals with varying degrees of knee pain. Participants (57.91 ± 8.04 y) with low impact knee pain (n = 95), high impact knee pain (n = 53), and pain-free controls (n = 26) completed self-reported pain, a blood draw, and an MRI scan. We used an epigenetic clock previously associated with knee pain (DNAmGrimAge), the subsequent difference of predicted epigenetic and brain age from chronological age (DNAmGrimAge-Difference and Brain-PAD, respectively). There was a significant main effect for pain impact group (F (2,167) = 3.847, P = 0.023, $${\rm{ }}\eta _p^2$$ = 0.038, ANCOVA) on Brain-PAD and DNAmGrimAge-difference (F (2,167) = 6.800, P = 0.001, $${\rm{ }}\eta _p^2$$ = 0.075, ANCOVA) after controlling for covariates. DNAmGrimAge-Difference and Brain-PAD were modestly correlated (r =0.198; P =0.010). Exploratory analysis revealed that DNAmGrimAge-difference mediated GCPS pain impact, GCPS pain severity, and pain-related disability scores on Brain-PAD. Based upon the current study findings, we suggest that pain could be a driver for accelerated brain aging via epigenome interactions.http://dx.doi.org/10.1080/15592294.2022.2111752epigeneticschronic painbrain agingagingmusculoskeletal pain |
| spellingShingle | Jessica A. Peterson Larissa J. Strath Chavier Laffitte Nodarse Asha Rani Zhiguang Huo Lingsong Meng Sean Yoder James H. Cole Thomas C. Foster Roger B. Fillingim Yenisel Cruz-Almeida Epigenetic Aging Mediates the Association between Pain Impact and Brain Aging in Middle to Older Age Individuals with Knee Pain Epigenetics epigenetics chronic pain brain aging aging musculoskeletal pain |
| title | Epigenetic Aging Mediates the Association between Pain Impact and Brain Aging in Middle to Older Age Individuals with Knee Pain |
| title_full | Epigenetic Aging Mediates the Association between Pain Impact and Brain Aging in Middle to Older Age Individuals with Knee Pain |
| title_fullStr | Epigenetic Aging Mediates the Association between Pain Impact and Brain Aging in Middle to Older Age Individuals with Knee Pain |
| title_full_unstemmed | Epigenetic Aging Mediates the Association between Pain Impact and Brain Aging in Middle to Older Age Individuals with Knee Pain |
| title_short | Epigenetic Aging Mediates the Association between Pain Impact and Brain Aging in Middle to Older Age Individuals with Knee Pain |
| title_sort | epigenetic aging mediates the association between pain impact and brain aging in middle to older age individuals with knee pain |
| topic | epigenetics chronic pain brain aging aging musculoskeletal pain |
| url | http://dx.doi.org/10.1080/15592294.2022.2111752 |
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