Combined Inhibition of IAPs and WEE1 Enhances TNFα- and Radiation-Induced Cell Death in Head and Neck Squamous Carcinoma

Combined Inhibition of IAPs and WEE1 Enhances TNFα- and Radiation-Induced Cell Death in Head and Neck Squamous Carcinoma

Head and neck squamous cell carcinoma (HNSCC) remains a prevalent diagnosis with current treatment options that include radiotherapy and immune-mediated therapies, in which tumor necrosis factor-α (TNFα) is a key mediator of cytotoxicity. However, HNSCC and other cancers often display TNFα resistanc...

Full description

Bibliographic Details
Main Authors: Tiffany Toni, Ramya Viswanathan, Yvette Robbins, Sreenivasulu Gunti, Xinping Yang, Angel Huynh, Hui Cheng, Anastasia L. Sowers, James B. Mitchell, Clint T. Allen, Ethan L. Morgan, Carter Van Waes
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cancers
Subjects:
HNSCC
WEE1 inhibitor
cIAP inhibitor
tumor necrosis factor (TNF)
Online Access:https://www.mdpi.com/2072-6694/15/4/1029

Internet

https://www.mdpi.com/2072-6694/15/4/1029

Similar Items