Development and validation of a ferroptosis-related lncRNAs signature to predict prognosis and microenvironment for melanoma
Abstract Ferroptosis plays an important role in cancer. However, studies about ferroptosis-related lncRNAs (FRLs) in skin cutaneous melanoma (SKCM) are scarce. Moreover, the relationship between prognostic FRLs and tumor microenvironment (TME) in melanoma remains unclear. This study investigates the...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2022-11-01
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| Series: | Discover Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s12672-022-00581-3 |
| _version_ | 1798018212183408640 |
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| author | Shuai Ping Ruining Gong Ke Lei Gong Qing Guangheng Zhang Jianghai Chen |
| author_facet | Shuai Ping Ruining Gong Ke Lei Gong Qing Guangheng Zhang Jianghai Chen |
| author_sort | Shuai Ping |
| collection | DOAJ |
| description | Abstract Ferroptosis plays an important role in cancer. However, studies about ferroptosis-related lncRNAs (FRLs) in skin cutaneous melanoma (SKCM) are scarce. Moreover, the relationship between prognostic FRLs and tumor microenvironment (TME) in melanoma remains unclear. This study investigates the potential prognostic value of FRLs and their association with TME in SKCM. The RNA-sequencing data of SKCM were downloaded from The Cancer Genome Atlas (TCGA) database. Melanoma patients were randomly divided into training and testing groups in a 1:1 ratio. A signature composed of 19 FRLs was developed by the least absolute shrinkage and selection operator (LASSO) regression analysis to divide patients into a low-risk group with a better prognosis and a high-risk group with a poor prognosis. Multivariate Cox regression analysis suggested that the risk score was an independent prognostic factor. The Area Under Curve (AUC) value of the risk score reached 0.768 in the training group and 0.770 in the testing group. Subsequent analysis proved that immune-related signaling pathways were significantly enriched in the low-risk group. The tumor immune cell infiltration analysis demonstrated that melanoma in the high-risk group tended to be immunologically “cold”. We identified a novel FRLs signature which could accurately predict the prognosis of patients with melanoma. |
| first_indexed | 2024-04-11T16:18:53Z |
| format | Article |
| id | doaj.art-aae1f576491e449c8ad8ecdc8925c913 |
| institution | Directory Open Access Journal |
| issn | 2730-6011 |
| language | English |
| last_indexed | 2024-04-11T16:18:53Z |
| publishDate | 2022-11-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj.art-aae1f576491e449c8ad8ecdc8925c9132022-12-22T04:14:25ZengSpringerDiscover Oncology2730-60112022-11-0113111510.1007/s12672-022-00581-3Development and validation of a ferroptosis-related lncRNAs signature to predict prognosis and microenvironment for melanomaShuai Ping0Ruining Gong1Ke Lei2Gong Qing3Guangheng Zhang4Jianghai Chen5Department of Gastroenterology, Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao UniversityDepartment of Gastroenterology, Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao UniversityTumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao UniversityDepartment of Gastroenterology, Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao UniversityDepartment of Orthopaedics, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Ferroptosis plays an important role in cancer. However, studies about ferroptosis-related lncRNAs (FRLs) in skin cutaneous melanoma (SKCM) are scarce. Moreover, the relationship between prognostic FRLs and tumor microenvironment (TME) in melanoma remains unclear. This study investigates the potential prognostic value of FRLs and their association with TME in SKCM. The RNA-sequencing data of SKCM were downloaded from The Cancer Genome Atlas (TCGA) database. Melanoma patients were randomly divided into training and testing groups in a 1:1 ratio. A signature composed of 19 FRLs was developed by the least absolute shrinkage and selection operator (LASSO) regression analysis to divide patients into a low-risk group with a better prognosis and a high-risk group with a poor prognosis. Multivariate Cox regression analysis suggested that the risk score was an independent prognostic factor. The Area Under Curve (AUC) value of the risk score reached 0.768 in the training group and 0.770 in the testing group. Subsequent analysis proved that immune-related signaling pathways were significantly enriched in the low-risk group. The tumor immune cell infiltration analysis demonstrated that melanoma in the high-risk group tended to be immunologically “cold”. We identified a novel FRLs signature which could accurately predict the prognosis of patients with melanoma.https://doi.org/10.1007/s12672-022-00581-3FerroptosislncRNAMelanomaPrognosisTumor microenvironment |
| spellingShingle | Shuai Ping Ruining Gong Ke Lei Gong Qing Guangheng Zhang Jianghai Chen Development and validation of a ferroptosis-related lncRNAs signature to predict prognosis and microenvironment for melanoma Discover Oncology Ferroptosis lncRNA Melanoma Prognosis Tumor microenvironment |
| title | Development and validation of a ferroptosis-related lncRNAs signature to predict prognosis and microenvironment for melanoma |
| title_full | Development and validation of a ferroptosis-related lncRNAs signature to predict prognosis and microenvironment for melanoma |
| title_fullStr | Development and validation of a ferroptosis-related lncRNAs signature to predict prognosis and microenvironment for melanoma |
| title_full_unstemmed | Development and validation of a ferroptosis-related lncRNAs signature to predict prognosis and microenvironment for melanoma |
| title_short | Development and validation of a ferroptosis-related lncRNAs signature to predict prognosis and microenvironment for melanoma |
| title_sort | development and validation of a ferroptosis related lncrnas signature to predict prognosis and microenvironment for melanoma |
| topic | Ferroptosis lncRNA Melanoma Prognosis Tumor microenvironment |
| url | https://doi.org/10.1007/s12672-022-00581-3 |
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