Deciphering the molecular mechanisms of stem cell dynamics in hair follicle regeneration
Abstract Hair follicles, which are connected to sebaceous glands in the skin, undergo cyclic periods of regeneration, degeneration, and rest throughout adult life in mammals. The crucial function of hair follicle stem cells is to maintain these hair growth cycles. Another vital aspect is the activit...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2024-01-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-023-01151-5 |
| _version_ | 1797275771907080192 |
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| author | Jung Hyun Lee Sekyu Choi |
| author_facet | Jung Hyun Lee Sekyu Choi |
| author_sort | Jung Hyun Lee |
| collection | DOAJ |
| description | Abstract Hair follicles, which are connected to sebaceous glands in the skin, undergo cyclic periods of regeneration, degeneration, and rest throughout adult life in mammals. The crucial function of hair follicle stem cells is to maintain these hair growth cycles. Another vital aspect is the activity of melanocyte stem cells, which differentiate into melanin-producing melanocytes, contributing to skin and hair pigmentation. Sebaceous gland stem cells also have a pivotal role in maintaining the skin barrier by regenerating mature sebocytes. These stem cells are maintained in a specialized microenvironment or niche and are regulated by internal and external signals, determining their dynamic behaviors in homeostasis and hair follicle regeneration. The activity of these stem cells is tightly controlled by various factors secreted by the niche components around the hair follicles, as well as immune-mediated damage signals, aging, metabolic status, and stress. In this study, we review these diverse stem cell regulatory and related molecular mechanisms of hair regeneration and disease conditions. Molecular insights would provide new perspectives on the disease mechanisms as well as hair and skin disorder treatment. |
| first_indexed | 2024-03-07T15:18:17Z |
| format | Article |
| id | doaj.art-aae23e09eb384e93a735dc941aac35de |
| institution | Directory Open Access Journal |
| issn | 2092-6413 |
| language | English |
| last_indexed | 2024-03-07T15:18:17Z |
| publishDate | 2024-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-aae23e09eb384e93a735dc941aac35de2024-03-05T17:47:56ZengNature Publishing GroupExperimental and Molecular Medicine2092-64132024-01-0156111011710.1038/s12276-023-01151-5Deciphering the molecular mechanisms of stem cell dynamics in hair follicle regenerationJung Hyun Lee0Sekyu Choi1Department of Dermatology, School of Medicine, University of WashingtonDepartment of Life Sciences, Pohang University of Science and Technology (POSTECH)Abstract Hair follicles, which are connected to sebaceous glands in the skin, undergo cyclic periods of regeneration, degeneration, and rest throughout adult life in mammals. The crucial function of hair follicle stem cells is to maintain these hair growth cycles. Another vital aspect is the activity of melanocyte stem cells, which differentiate into melanin-producing melanocytes, contributing to skin and hair pigmentation. Sebaceous gland stem cells also have a pivotal role in maintaining the skin barrier by regenerating mature sebocytes. These stem cells are maintained in a specialized microenvironment or niche and are regulated by internal and external signals, determining their dynamic behaviors in homeostasis and hair follicle regeneration. The activity of these stem cells is tightly controlled by various factors secreted by the niche components around the hair follicles, as well as immune-mediated damage signals, aging, metabolic status, and stress. In this study, we review these diverse stem cell regulatory and related molecular mechanisms of hair regeneration and disease conditions. Molecular insights would provide new perspectives on the disease mechanisms as well as hair and skin disorder treatment.https://doi.org/10.1038/s12276-023-01151-5 |
| spellingShingle | Jung Hyun Lee Sekyu Choi Deciphering the molecular mechanisms of stem cell dynamics in hair follicle regeneration Experimental and Molecular Medicine |
| title | Deciphering the molecular mechanisms of stem cell dynamics in hair follicle regeneration |
| title_full | Deciphering the molecular mechanisms of stem cell dynamics in hair follicle regeneration |
| title_fullStr | Deciphering the molecular mechanisms of stem cell dynamics in hair follicle regeneration |
| title_full_unstemmed | Deciphering the molecular mechanisms of stem cell dynamics in hair follicle regeneration |
| title_short | Deciphering the molecular mechanisms of stem cell dynamics in hair follicle regeneration |
| title_sort | deciphering the molecular mechanisms of stem cell dynamics in hair follicle regeneration |
| url | https://doi.org/10.1038/s12276-023-01151-5 |
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