Bioactive Polymeric Materials for Tissue Repair
Bioactive polymeric materials based on calcium phosphates have tremendous appeal for hard tissue repair because of their well-documented biocompatibility. Amorphous calcium phosphate (ACP)-based ones additionally protect against unwanted demineralization and actively support regeneration of hard tis...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2017-01-01
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| Series: | Journal of Functional Biomaterials |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2079-4983/8/1/4 |
| _version_ | 1798043650150629376 |
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| author | Diane R. Bienek Wojtek Tutak Drago Skrtic |
| author_facet | Diane R. Bienek Wojtek Tutak Drago Skrtic |
| author_sort | Diane R. Bienek |
| collection | DOAJ |
| description | Bioactive polymeric materials based on calcium phosphates have tremendous appeal for hard tissue repair because of their well-documented biocompatibility. Amorphous calcium phosphate (ACP)-based ones additionally protect against unwanted demineralization and actively support regeneration of hard tissue minerals. Our group has been investigating the structure/composition/property relationships of ACP polymeric composites for the last two decades. Here, we present ACP’s dispersion in a polymer matrix and the fine-tuning of the resin affects the physicochemical, mechanical, and biological properties of ACP polymeric composites. These studies illustrate how the filler/resin interface and monomer/polymer molecular structure affect the material’s critical properties, such as ion release and mechanical strength. We also present evidence of the remineralization efficacy of ACP composites when exposed to accelerated acidic challenges representative of oral environment conditions. The utility of ACP has recently been extended to include airbrushing as a platform technology for fabrication of nanofiber scaffolds. These studies, focused on assessing the feasibility of incorporating ACP into various polymer fibers, also included the release kinetics of bioactive calcium and phosphate ions from nanofibers and evaluate the biorelevance of the polymeric ACP fiber networks. We also discuss the potential for future integration of the existing ACP scaffolds into therapeutic delivery systems used in the precision medicine field. |
| first_indexed | 2024-04-11T22:52:01Z |
| format | Article |
| id | doaj.art-aae2ccca0fba4021991f09839d78610b |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-04-11T22:52:01Z |
| publishDate | 2017-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-aae2ccca0fba4021991f09839d78610b2022-12-22T03:58:33ZengMDPI AGJournal of Functional Biomaterials2079-49832017-01-0181410.3390/jfb8010004jfb8010004Bioactive Polymeric Materials for Tissue RepairDiane R. Bienek0Wojtek Tutak1Drago Skrtic2Volpe Research Center, ADA Foundation, Gaithersburg, MD 20899, USAVolpe Research Center, ADA Foundation, Gaithersburg, MD 20899, USAVolpe Research Center, ADA Foundation, Gaithersburg, MD 20899, USABioactive polymeric materials based on calcium phosphates have tremendous appeal for hard tissue repair because of their well-documented biocompatibility. Amorphous calcium phosphate (ACP)-based ones additionally protect against unwanted demineralization and actively support regeneration of hard tissue minerals. Our group has been investigating the structure/composition/property relationships of ACP polymeric composites for the last two decades. Here, we present ACP’s dispersion in a polymer matrix and the fine-tuning of the resin affects the physicochemical, mechanical, and biological properties of ACP polymeric composites. These studies illustrate how the filler/resin interface and monomer/polymer molecular structure affect the material’s critical properties, such as ion release and mechanical strength. We also present evidence of the remineralization efficacy of ACP composites when exposed to accelerated acidic challenges representative of oral environment conditions. The utility of ACP has recently been extended to include airbrushing as a platform technology for fabrication of nanofiber scaffolds. These studies, focused on assessing the feasibility of incorporating ACP into various polymer fibers, also included the release kinetics of bioactive calcium and phosphate ions from nanofibers and evaluate the biorelevance of the polymeric ACP fiber networks. We also discuss the potential for future integration of the existing ACP scaffolds into therapeutic delivery systems used in the precision medicine field.http://www.mdpi.com/2079-4983/8/1/4airbrushingblow spinningamorphous calcium phosphatebone repaircell/fiber interactionsnanofibersremineralizing polymeric composite |
| spellingShingle | Diane R. Bienek Wojtek Tutak Drago Skrtic Bioactive Polymeric Materials for Tissue Repair Journal of Functional Biomaterials airbrushing blow spinning amorphous calcium phosphate bone repair cell/fiber interactions nanofibers remineralizing polymeric composite |
| title | Bioactive Polymeric Materials for Tissue Repair |
| title_full | Bioactive Polymeric Materials for Tissue Repair |
| title_fullStr | Bioactive Polymeric Materials for Tissue Repair |
| title_full_unstemmed | Bioactive Polymeric Materials for Tissue Repair |
| title_short | Bioactive Polymeric Materials for Tissue Repair |
| title_sort | bioactive polymeric materials for tissue repair |
| topic | airbrushing blow spinning amorphous calcium phosphate bone repair cell/fiber interactions nanofibers remineralizing polymeric composite |
| url | http://www.mdpi.com/2079-4983/8/1/4 |
| work_keys_str_mv | AT dianerbienek bioactivepolymericmaterialsfortissuerepair AT wojtektutak bioactivepolymericmaterialsfortissuerepair AT dragoskrtic bioactivepolymericmaterialsfortissuerepair |