Urinary Schistosomiasis: Review
In this review, the clinical manifestations of urinary schistosomiasis are displayed from a pathogenetic perspective. According to the prevailing host’s immune response profile, urinary schistosomiasis may be broadly categorized into cell-mediated and immune-complex-mediated disorders. The former, u...
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| Format: | Article |
| Language: | English |
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Elsevier
2013-09-01
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| Series: | Journal of Advanced Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090123212000628 |
| _version_ | 1819043112608071680 |
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| author | Rashad S. Barsoum |
| author_facet | Rashad S. Barsoum |
| author_sort | Rashad S. Barsoum |
| collection | DOAJ |
| description | In this review, the clinical manifestations of urinary schistosomiasis are displayed from a pathogenetic perspective. According to the prevailing host’s immune response profile, urinary schistosomiasis may be broadly categorized into cell-mediated and immune-complex-mediated disorders. The former, usually due to Schistosoma haematobium infection, are attributed to the formation of granulomata along the entire urinary tract. As they heal with excessive fibrosis, they may lead to strictures, calcifications and urodynamic abnormalities. The main impact is lower urinary, the site of heaviest ovi-position. Secondary bacterial or viral infection is common, any may be incriminated in secondary stone formation of the development of bladder malignancy. Immune-complex mediated lesions are usually associated with hepatosplenic schistosomiasis due to Schistosoma mansoni infection. Circulating complexes composed of schistosomal gut antigens and different classes of immunoglobulins deposit in the kidneys leading to several patterns of glomerular pathology. The latter have been categorized under six classes based on the histological and immunofluorescence profile. These classes have been linked to respective clinical manifestations and depend on the stage of evolution of the host’s immune response, extent of associated hepatic fibrosis and co-infection with salmonella or hepatitis C. Secondary amyloidosis develops in 15% of such patients, representing a critical impairment of macrophage function. Conclusion: The wide clinicopathological spectrum of urinary schistosomiasis mirrors the evolution of the host’s immune response according to chronicity of infection, bacterial or viral co-infection and, in the case of glomerulonephritis, to the extent of hepatic co-morbidity. |
| first_indexed | 2024-12-21T09:51:36Z |
| format | Article |
| id | doaj.art-aae3c0fff5c441379175c83832f7caab |
| institution | Directory Open Access Journal |
| issn | 2090-1232 2090-1224 |
| language | English |
| last_indexed | 2024-12-21T09:51:36Z |
| publishDate | 2013-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Advanced Research |
| spelling | doaj.art-aae3c0fff5c441379175c83832f7caab2022-12-21T19:08:10ZengElsevierJournal of Advanced Research2090-12322090-12242013-09-014545345910.1016/j.jare.2012.08.004Urinary Schistosomiasis: ReviewRashad S. BarsoumIn this review, the clinical manifestations of urinary schistosomiasis are displayed from a pathogenetic perspective. According to the prevailing host’s immune response profile, urinary schistosomiasis may be broadly categorized into cell-mediated and immune-complex-mediated disorders. The former, usually due to Schistosoma haematobium infection, are attributed to the formation of granulomata along the entire urinary tract. As they heal with excessive fibrosis, they may lead to strictures, calcifications and urodynamic abnormalities. The main impact is lower urinary, the site of heaviest ovi-position. Secondary bacterial or viral infection is common, any may be incriminated in secondary stone formation of the development of bladder malignancy. Immune-complex mediated lesions are usually associated with hepatosplenic schistosomiasis due to Schistosoma mansoni infection. Circulating complexes composed of schistosomal gut antigens and different classes of immunoglobulins deposit in the kidneys leading to several patterns of glomerular pathology. The latter have been categorized under six classes based on the histological and immunofluorescence profile. These classes have been linked to respective clinical manifestations and depend on the stage of evolution of the host’s immune response, extent of associated hepatic fibrosis and co-infection with salmonella or hepatitis C. Secondary amyloidosis develops in 15% of such patients, representing a critical impairment of macrophage function. Conclusion: The wide clinicopathological spectrum of urinary schistosomiasis mirrors the evolution of the host’s immune response according to chronicity of infection, bacterial or viral co-infection and, in the case of glomerulonephritis, to the extent of hepatic co-morbidity.http://www.sciencedirect.com/science/article/pii/S2090123212000628GlomerulonephritisHepatosplenic schistosomiasisAmyloidosisBladder cancerSalmonellosisHepatitis C |
| spellingShingle | Rashad S. Barsoum Urinary Schistosomiasis: Review Journal of Advanced Research Glomerulonephritis Hepatosplenic schistosomiasis Amyloidosis Bladder cancer Salmonellosis Hepatitis C |
| title | Urinary Schistosomiasis: Review |
| title_full | Urinary Schistosomiasis: Review |
| title_fullStr | Urinary Schistosomiasis: Review |
| title_full_unstemmed | Urinary Schistosomiasis: Review |
| title_short | Urinary Schistosomiasis: Review |
| title_sort | urinary schistosomiasis review |
| topic | Glomerulonephritis Hepatosplenic schistosomiasis Amyloidosis Bladder cancer Salmonellosis Hepatitis C |
| url | http://www.sciencedirect.com/science/article/pii/S2090123212000628 |
| work_keys_str_mv | AT rashadsbarsoum urinaryschistosomiasisreview |