Risk of adverse perinatal outcomes among women with clinical and subclinical histopathological chorioamnionitis
IntroductionHistologic chorioamnionitis (HCA) is a placental inflammatory condition associated with adverse perinatal outcomes (APOs). This historical cohort study explores the risk of APOs in pregnant women with HCA and compares the impact of clinical chorioamnionitis (CCA) with subclinical chorioa...
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1242962/full |
| _version_ | 1797271828838744064 |
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| author | Andrea Olguín-Ortega Ricardo Figueroa-Damian Martha Leticia Palafox-Vargas Enrique Reyes-Muñoz |
| author_facet | Andrea Olguín-Ortega Ricardo Figueroa-Damian Martha Leticia Palafox-Vargas Enrique Reyes-Muñoz |
| author_sort | Andrea Olguín-Ortega |
| collection | DOAJ |
| description | IntroductionHistologic chorioamnionitis (HCA) is a placental inflammatory condition associated with adverse perinatal outcomes (APOs). This historical cohort study explores the risk of APOs in pregnant women with HCA and compares the impact of clinical chorioamnionitis (CCA) with subclinical chorioamnionitis (SCCA).MethodologyPlacentas were evaluated by a perinatal pathologist tand all women with HCA were included. Two groups were integrated: (1) women with clinical chorioamnionitis (CCA) and (2) women with subclinical chorioamnionitis (SCCA). Additionally, we conducted a secondary analysis to compare the prevalence of APOs among stage 1, 2 and 3 of HCA and the risk of APOs between grades 1 and 2 of HCA. The APOs analyzed were preterm birth, stillbirth, neonatal weight < 1,500 g, neonatal sepsis. Relative risk with 95% confidence interval was calculated.ResultsThe study included 41 cases of CCA and 270 cases of SCCA. The mean gestational age at diagnosis and birth was 30.2 ± 5.4 weeks and 32.5 ± 5.1 weeks, for group 1 and 2, respectively. The study also found that women with HCA stage 3 and grade 2 had a higher prevalence and risk of adverse perinatal outcomes.DiscussionThe findings of this study suggest the importance of placental histological study to excluded SCCA, which represents a significant risk to both maternal and neonatal health, contributing to high morbidity and mortality. |
| first_indexed | 2024-03-07T14:14:51Z |
| format | Article |
| id | doaj.art-aae4ddbfac4b487e8461cc5dbbd3268a |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-07T14:14:51Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-aae4ddbfac4b487e8461cc5dbbd3268a2024-03-06T13:19:55ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2024-03-011110.3389/fmed.2024.12429621242962Risk of adverse perinatal outcomes among women with clinical and subclinical histopathological chorioamnionitisAndrea Olguín-Ortega0Ricardo Figueroa-Damian1Martha Leticia Palafox-Vargas2Enrique Reyes-Muñoz3Department of Gynecology, National Institute of Perinatology, Mexico City, MexicoDepartment of Infectology, National Institute of Perinatology, Mexico City, MexicoDepartment of Pathology, National Institute of Perinatology, Mexico City, MexicoCoordination of Gynecological and Perinatal Endocrinology, National Institute of Perinatology, Mexico City, MexicoIntroductionHistologic chorioamnionitis (HCA) is a placental inflammatory condition associated with adverse perinatal outcomes (APOs). This historical cohort study explores the risk of APOs in pregnant women with HCA and compares the impact of clinical chorioamnionitis (CCA) with subclinical chorioamnionitis (SCCA).MethodologyPlacentas were evaluated by a perinatal pathologist tand all women with HCA were included. Two groups were integrated: (1) women with clinical chorioamnionitis (CCA) and (2) women with subclinical chorioamnionitis (SCCA). Additionally, we conducted a secondary analysis to compare the prevalence of APOs among stage 1, 2 and 3 of HCA and the risk of APOs between grades 1 and 2 of HCA. The APOs analyzed were preterm birth, stillbirth, neonatal weight < 1,500 g, neonatal sepsis. Relative risk with 95% confidence interval was calculated.ResultsThe study included 41 cases of CCA and 270 cases of SCCA. The mean gestational age at diagnosis and birth was 30.2 ± 5.4 weeks and 32.5 ± 5.1 weeks, for group 1 and 2, respectively. The study also found that women with HCA stage 3 and grade 2 had a higher prevalence and risk of adverse perinatal outcomes.DiscussionThe findings of this study suggest the importance of placental histological study to excluded SCCA, which represents a significant risk to both maternal and neonatal health, contributing to high morbidity and mortality.https://www.frontiersin.org/articles/10.3389/fmed.2024.1242962/fullchorioamnionitispregnancy outcomeplacentapremature birthstillbirth |
| spellingShingle | Andrea Olguín-Ortega Ricardo Figueroa-Damian Martha Leticia Palafox-Vargas Enrique Reyes-Muñoz Risk of adverse perinatal outcomes among women with clinical and subclinical histopathological chorioamnionitis Frontiers in Medicine chorioamnionitis pregnancy outcome placenta premature birth stillbirth |
| title | Risk of adverse perinatal outcomes among women with clinical and subclinical histopathological chorioamnionitis |
| title_full | Risk of adverse perinatal outcomes among women with clinical and subclinical histopathological chorioamnionitis |
| title_fullStr | Risk of adverse perinatal outcomes among women with clinical and subclinical histopathological chorioamnionitis |
| title_full_unstemmed | Risk of adverse perinatal outcomes among women with clinical and subclinical histopathological chorioamnionitis |
| title_short | Risk of adverse perinatal outcomes among women with clinical and subclinical histopathological chorioamnionitis |
| title_sort | risk of adverse perinatal outcomes among women with clinical and subclinical histopathological chorioamnionitis |
| topic | chorioamnionitis pregnancy outcome placenta premature birth stillbirth |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1242962/full |
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