Cardiac mechanostructure: Using mechanics and anisotropy as inspiration for developing epicardial therapies in treating myocardial infarction
The mechanical environment and anisotropic structure of the heart modulate cardiac function at the cellular, tissue and organ levels. During myocardial infarction (MI) and subsequent healing, however, this landscape changes significantly. In order to engineer cardiac biomaterials with the appropriat...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2021-07-01
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| Series: | Bioactive Materials |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X20303406 |
| _version_ | 1827279143224475648 |
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| author | Kiera D. Dwyer Kareen L.K. Coulombe |
| author_facet | Kiera D. Dwyer Kareen L.K. Coulombe |
| author_sort | Kiera D. Dwyer |
| collection | DOAJ |
| description | The mechanical environment and anisotropic structure of the heart modulate cardiac function at the cellular, tissue and organ levels. During myocardial infarction (MI) and subsequent healing, however, this landscape changes significantly. In order to engineer cardiac biomaterials with the appropriate properties to enhance function after MI, the changes in the myocardium induced by MI must be clearly identified. In this review, we focus on the mechanical and structural properties of the healthy and infarcted myocardium in order to gain insight about the environment in which biomaterial-based cardiac therapies are expected to perform and the functional deficiencies caused by MI that the therapy must address. From this understanding, we discuss epicardial therapies for MI inspired by the mechanics and anisotropy of the heart focusing on passive devices, which feature a biomaterials approach, and active devices, which feature robotic and cellular components. Through this review, a detailed analysis is provided in order to inspire further development and translation of epicardial therapies for MI. |
| first_indexed | 2024-04-24T08:14:13Z |
| format | Article |
| id | doaj.art-aae55b4a5e1f4f6799968e5046545a29 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:14:13Z |
| publishDate | 2021-07-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-aae55b4a5e1f4f6799968e5046545a292024-04-17T04:34:35ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2021-07-016721982220Cardiac mechanostructure: Using mechanics and anisotropy as inspiration for developing epicardial therapies in treating myocardial infarctionKiera D. Dwyer0Kareen L.K. Coulombe1Center for Biomedical Engineering, School of Engineering, Brown University, Providence, RI, USACorresponding author. School of Engineering, Brown University, 184 Hope Street, Box D, Providence, RI, 02912, USA.; Center for Biomedical Engineering, School of Engineering, Brown University, Providence, RI, USAThe mechanical environment and anisotropic structure of the heart modulate cardiac function at the cellular, tissue and organ levels. During myocardial infarction (MI) and subsequent healing, however, this landscape changes significantly. In order to engineer cardiac biomaterials with the appropriate properties to enhance function after MI, the changes in the myocardium induced by MI must be clearly identified. In this review, we focus on the mechanical and structural properties of the healthy and infarcted myocardium in order to gain insight about the environment in which biomaterial-based cardiac therapies are expected to perform and the functional deficiencies caused by MI that the therapy must address. From this understanding, we discuss epicardial therapies for MI inspired by the mechanics and anisotropy of the heart focusing on passive devices, which feature a biomaterials approach, and active devices, which feature robotic and cellular components. Through this review, a detailed analysis is provided in order to inspire further development and translation of epicardial therapies for MI.http://www.sciencedirect.com/science/article/pii/S2452199X20303406AnisotropyCardiac biomechanicsEpicardial therapiesVentricular restraintCardiac tissue engineering |
| spellingShingle | Kiera D. Dwyer Kareen L.K. Coulombe Cardiac mechanostructure: Using mechanics and anisotropy as inspiration for developing epicardial therapies in treating myocardial infarction Bioactive Materials Anisotropy Cardiac biomechanics Epicardial therapies Ventricular restraint Cardiac tissue engineering |
| title | Cardiac mechanostructure: Using mechanics and anisotropy as inspiration for developing epicardial therapies in treating myocardial infarction |
| title_full | Cardiac mechanostructure: Using mechanics and anisotropy as inspiration for developing epicardial therapies in treating myocardial infarction |
| title_fullStr | Cardiac mechanostructure: Using mechanics and anisotropy as inspiration for developing epicardial therapies in treating myocardial infarction |
| title_full_unstemmed | Cardiac mechanostructure: Using mechanics and anisotropy as inspiration for developing epicardial therapies in treating myocardial infarction |
| title_short | Cardiac mechanostructure: Using mechanics and anisotropy as inspiration for developing epicardial therapies in treating myocardial infarction |
| title_sort | cardiac mechanostructure using mechanics and anisotropy as inspiration for developing epicardial therapies in treating myocardial infarction |
| topic | Anisotropy Cardiac biomechanics Epicardial therapies Ventricular restraint Cardiac tissue engineering |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X20303406 |
| work_keys_str_mv | AT kieraddwyer cardiacmechanostructureusingmechanicsandanisotropyasinspirationfordevelopingepicardialtherapiesintreatingmyocardialinfarction AT kareenlkcoulombe cardiacmechanostructureusingmechanicsandanisotropyasinspirationfordevelopingepicardialtherapiesintreatingmyocardialinfarction |