Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug Delivery
Nanocarriers have therapeutic potential to facilitate drug delivery, including biological agents, small-molecule drugs, and nucleic acids. However, their efficiency is limited by several factors; among which, endosomal/lysosomal degradation after endocytosis is the most important. This review summar...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Association for the Advancement of Science (AAAS)
2023-01-01
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| Series: | Research |
| Online Access: | https://spj.science.org/doi/10.34133/research.0148 |
| _version_ | 1797283878442893312 |
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| author | Chong Qiu Fei Xia Junzhe Zhang Qiaoli Shi Yuqing Meng Chen Wang Huanhuan Pang Liwei Gu Chengchao Xu Qiuyan Guo Jigang Wang |
| author_facet | Chong Qiu Fei Xia Junzhe Zhang Qiaoli Shi Yuqing Meng Chen Wang Huanhuan Pang Liwei Gu Chengchao Xu Qiuyan Guo Jigang Wang |
| author_sort | Chong Qiu |
| collection | DOAJ |
| description | Nanocarriers have therapeutic potential to facilitate drug delivery, including biological agents, small-molecule drugs, and nucleic acids. However, their efficiency is limited by several factors; among which, endosomal/lysosomal degradation after endocytosis is the most important. This review summarizes advanced strategies for overcoming endosomal/lysosomal barriers to efficient nanodrug delivery based on the perspective of cellular uptake and intracellular transport mechanisms. These strategies include promoting endosomal/lysosomal escape, using non-endocytic methods of delivery to directly cross the cell membrane to evade endosomes/lysosomes and making a detour pathway to evade endosomes/lysosomes. On the basis of the findings of this review, we proposed several promising strategies for overcoming endosomal/lysosomal barriers through the smarter and more efficient design of nanodrug delivery systems for future clinical applications. |
| first_indexed | 2024-03-07T17:38:11Z |
| format | Article |
| id | doaj.art-aae7928c8d5e4597ac04055a2db23fd9 |
| institution | Directory Open Access Journal |
| issn | 2639-5274 |
| language | English |
| last_indexed | 2024-03-07T17:38:11Z |
| publishDate | 2023-01-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | Research |
| spelling | doaj.art-aae7928c8d5e4597ac04055a2db23fd92024-03-02T16:25:32ZengAmerican Association for the Advancement of Science (AAAS)Research2639-52742023-01-01610.34133/research.0148Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug DeliveryChong Qiu0Fei Xia1Junzhe Zhang2Qiaoli Shi3Yuqing Meng4Chen Wang5Huanhuan Pang6Liwei Gu7Chengchao Xu8Qiuyan Guo9Jigang Wang10Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.Nanocarriers have therapeutic potential to facilitate drug delivery, including biological agents, small-molecule drugs, and nucleic acids. However, their efficiency is limited by several factors; among which, endosomal/lysosomal degradation after endocytosis is the most important. This review summarizes advanced strategies for overcoming endosomal/lysosomal barriers to efficient nanodrug delivery based on the perspective of cellular uptake and intracellular transport mechanisms. These strategies include promoting endosomal/lysosomal escape, using non-endocytic methods of delivery to directly cross the cell membrane to evade endosomes/lysosomes and making a detour pathway to evade endosomes/lysosomes. On the basis of the findings of this review, we proposed several promising strategies for overcoming endosomal/lysosomal barriers through the smarter and more efficient design of nanodrug delivery systems for future clinical applications.https://spj.science.org/doi/10.34133/research.0148 |
| spellingShingle | Chong Qiu Fei Xia Junzhe Zhang Qiaoli Shi Yuqing Meng Chen Wang Huanhuan Pang Liwei Gu Chengchao Xu Qiuyan Guo Jigang Wang Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug Delivery Research |
| title | Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug Delivery |
| title_full | Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug Delivery |
| title_fullStr | Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug Delivery |
| title_full_unstemmed | Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug Delivery |
| title_short | Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug Delivery |
| title_sort | advanced strategies for overcoming endosomal lysosomal barrier in nanodrug delivery |
| url | https://spj.science.org/doi/10.34133/research.0148 |
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