Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug Delivery

Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug Delivery

Nanocarriers have therapeutic potential to facilitate drug delivery, including biological agents, small-molecule drugs, and nucleic acids. However, their efficiency is limited by several factors; among which, endosomal/lysosomal degradation after endocytosis is the most important. This review summar...

Full description

Bibliographic Details
Main Authors:	Chong Qiu, Fei Xia, Junzhe Zhang, Qiaoli Shi, Yuqing Meng, Chen Wang, Huanhuan Pang, Liwei Gu, Chengchao Xu, Qiuyan Guo, Jigang Wang
Format:	Article
Language:	English
Published:	American Association for the Advancement of Science (AAAS) 2023-01-01
Series:	Research
Online Access:	https://spj.science.org/doi/10.34133/research.0148

Similar Items

Nanodrugs Detonate Lysosome Bombs
by: Yuting Xiang, et al.
Published: (2022-05-01)

Preparation and application of calcium phosphate nanocarriers in drug delivery
by: Chong Qiu, et al.
Published: (2022-12-01)

Engineering small molecule nanodrugs to overcome barriers for cancer therapy
by: Yuan Ma, et al.
Published: (2020-09-01)

A lysosome-targeted dextran-doxorubicin nanodrug overcomes doxorubicin-induced chemoresistance of myeloid leukemia
by: Yunxin Zeng, et al.
Published: (2021-11-01)

Camptothecin-based nanodrug delivery systems
by: Yan Wen, et al.
Published: (2017-08-01)

Altered endosomal-lysosomal biogenesis in melanoma
by: Giang T. Lam, et al.
Published: (2023-09-01)

Natural Polysaccharide-Based Nanodrug Delivery Systems for Treatment of Diabetes
by: Aijun Qiu, et al.
Published: (2022-08-01)

Decompression Process of Glycerol Shock Treatment Can Overcome Endo-Lysosomal Barriers for Intracellular Delivery
by: Shupeng Wang, et al.
Published: (2020-12-01)

Overcoming Drug Resistance in Breast Cancer Using Quercetin Nanodrugs
by: Fatemeh Sorayabin Mobarhan, et al.
Published: (2022-07-01)

Self-assembled ternary hybrid nanodrugs for overcoming tumor resistance and metastasis
by: Xu Cheng, et al.
Published: (2021-11-01)

Advances in tumor immunomodulation based on nanodrug delivery systems
by: Bo Wang, et al.
Published: (2023-12-01)

Nanodrug Delivery Systems for the Treatment of Ovarian Cancer
by: Jonathan M. Pantshwa, et al.
Published: (2020-01-01)

Implications of Altered Endosome and Lysosome Biology in Space Environments
by: Ian R. D. Johnson, et al.
Published: (2020-11-01)

Endosomal-Lysosomal Processing of Neurodegeneration-Associated Proteins in Astrocytes
by: Ching-On Wong
Published: (2020-07-01)

Nanodrug Delivery in Reversing Multidrug Resistance in Cancer Cells
by: Sonali eKapse-Mistry, et al.
Published: (2014-07-01)

The Endosomal–Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo
by: Tal Nuriel, et al.
Published: (2017-12-01)

Current Researches on Nanodrug Delivery Systems in Bladder Cancer Intravesical Chemotherapy
by: Yilei Lu, et al.
Published: (2022-05-01)

Review of the pharmacokinetics of nanodrugs
by: Shao Xiaotong, et al.
Published: (2023-03-01)

Overcoming multidrug-resistant lung cancer by mitochondrial-associated ATP inhibition using nanodrugs
by: Jun-Young Park, et al.
Published: (2023-01-01)

Enhanced nanodrug delivery in tumors after near-infrared photoimmunotherapy
by: Inagaki Fuyuki F., et al.
Published: (2019-09-01)

Late Endosomal/Lysosomal Cholesterol Accumulation Is a Host Cell-Protective Mechanism Inhibiting Endosomal Escape of Influenza A Virus
by: Alexander Kühnl, et al.
Published: (2018-09-01)

A highly efficient protein corona-based proteomic analysis strategy for the discovery of pharmacodynamic biomarkers
by: Yuqing Meng, et al.
Published: (2022-12-01)

Distinct effects of endosomal escape and inhibition of endosomal trafficking on gene delivery via electrotransfection.
by: Lisa D Cervia, et al.
Published: (2017-01-01)

Cadmium induces endosomal/lysosomal enlargement and blocks autophagy flux in rat hepatocytes by damaging microtubules
by: Junzhao Yuan, et al.
Published: (2021-12-01)

Impairment of the autophagy–lysosomal pathway in Alzheimer's diseases: Pathogenic mechanisms and therapeutic potential
by: Wei Zhang, et al.
Published: (2022-03-01)

Overcoming Barriers to Healthcare Access and Delivery
by: Foluso Ayeni, et al.
Published: (2018-07-01)

Intracellular Trafficking Pathways of Edwardsiella tarda: From Clathrin- and Caveolin-Mediated Endocytosis to Endosome and Lysosome
by: Zhi-hai Sui, et al.
Published: (2017-09-01)

Immunoengineering via Chimeric Antigen Receptor-T Cell Therapy: Reprogramming Nanodrug Delivery
by: Theodora Katopodi, et al.
Published: (2023-10-01)

Advances in therapeutic nanodrug delivery systems for infectious lung diseases: a review
by: Gang Sheng, et al.
Published: (2022-08-01)

Nanodrugs used in cancer therapy
by: Katerina Kopeckova, et al.
Published: (2019-06-01)

Ubiquitin ligase Nedd4 promotes alpha-synuclein degradation by the endosomal-lysosomal pathway.
by: Tofaris, G, et al.
Published: (2011)

Endosome and Lysosome Membrane Properties Functionally Link to γ-Secretase in Live/Intact Cells
by: Mei C. Q. Houser, et al.
Published: (2023-02-01)

Membrane protein trafficking in the anti-tumor immune response: work of endosomal-lysosomal system
by: Yan Jin, et al.
Published: (2022-12-01)

Consecutive functions of small GTPases guide HOPS-mediated tethering of late endosomes and lysosomes
by: Ariane Schleinitz, et al.
Published: (2023-01-01)

Activation mobilizes the cholesterol in the late endosomes-lysosomes of Niemann Pick type C cells.
by: Yvonne Lange, et al.
Published: (2012-01-01)

Hydrophilic Poly(glutamic acid)-Based Nanodrug Delivery System: Structural Influence and Antitumor Efficacy
by: Yifei Guo, et al.
Published: (2022-05-01)

CAR-neutrophil mediated delivery of tumor-microenvironment responsive nanodrugs for glioblastoma chemo-immunotherapy
by: Yun Chang, et al.
Published: (2023-04-01)

Controllable loading and release of nanodrugs in polymeric vesicles
by: Junwei Zhou, et al.
Published: (2022-12-01)

O2-loaded pH-responsive multifunctional nanodrug carrier for overcoming hypoxia and highly efficient chemo-photodynamic cancer therapy
by: Xie, Zhongxi, et al.
Published: (2021)

The clinical regimens and cell membrane camouflaged nanodrug delivery systems in hematologic malignancies treatment
by: Yuanyuan Liu, et al.
Published: (2024-04-01)