SLC26 family: a new insight for kidney stone disease
The solute-linked carrier 26 (SLC26) protein family is comprised of multifunctional transporters of substrates that include oxalate, sulphate, and chloride. Disorders of oxalate homeostasis cause hyperoxalemia and hyperoxaluria, leading to urinary calcium oxalate precipitation and urolithogenesis. S...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1118342/full |
| _version_ | 1797821032214560768 |
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| author | Jialin Li Jialin Li Sigen Huang Sigen Huang Shengyin Liu Shengyin Liu Xinzhi Liao Xinzhi Liao Sheng Yan Sheng Yan Quanliang Liu |
| author_facet | Jialin Li Jialin Li Sigen Huang Sigen Huang Shengyin Liu Shengyin Liu Xinzhi Liao Xinzhi Liao Sheng Yan Sheng Yan Quanliang Liu |
| author_sort | Jialin Li |
| collection | DOAJ |
| description | The solute-linked carrier 26 (SLC26) protein family is comprised of multifunctional transporters of substrates that include oxalate, sulphate, and chloride. Disorders of oxalate homeostasis cause hyperoxalemia and hyperoxaluria, leading to urinary calcium oxalate precipitation and urolithogenesis. SLC26 proteins are aberrantly expressed during kidney stone formation, and consequently may present therapeutic targets. SLC26 protein inhibitors are in preclinical development. In this review, we integrate the findings of recent reports with clinical data to highlight the role of SLC26 proteins in oxalate metabolism during urolithogenesis, and discuss limitations of current studies and potential directions for future research. |
| first_indexed | 2024-03-13T09:46:47Z |
| format | Article |
| id | doaj.art-aae7c15b54694f1e8fc1a5de56e41434 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-03-13T09:46:47Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-aae7c15b54694f1e8fc1a5de56e414342023-05-25T04:13:58ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-05-011410.3389/fphys.2023.11183421118342SLC26 family: a new insight for kidney stone diseaseJialin Li0Jialin Li1Sigen Huang2Sigen Huang3Shengyin Liu4Shengyin Liu5Xinzhi Liao6Xinzhi Liao7Sheng Yan8Sheng Yan9Quanliang Liu10The First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaThe First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaThe First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaThe First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaThe First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaDepartment of Urology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaThe solute-linked carrier 26 (SLC26) protein family is comprised of multifunctional transporters of substrates that include oxalate, sulphate, and chloride. Disorders of oxalate homeostasis cause hyperoxalemia and hyperoxaluria, leading to urinary calcium oxalate precipitation and urolithogenesis. SLC26 proteins are aberrantly expressed during kidney stone formation, and consequently may present therapeutic targets. SLC26 protein inhibitors are in preclinical development. In this review, we integrate the findings of recent reports with clinical data to highlight the role of SLC26 proteins in oxalate metabolism during urolithogenesis, and discuss limitations of current studies and potential directions for future research.https://www.frontiersin.org/articles/10.3389/fphys.2023.1118342/fullSLC26kidney stoneoxalatehyperoxaluriaoxalate metabolism |
| spellingShingle | Jialin Li Jialin Li Sigen Huang Sigen Huang Shengyin Liu Shengyin Liu Xinzhi Liao Xinzhi Liao Sheng Yan Sheng Yan Quanliang Liu SLC26 family: a new insight for kidney stone disease Frontiers in Physiology SLC26 kidney stone oxalate hyperoxaluria oxalate metabolism |
| title | SLC26 family: a new insight for kidney stone disease |
| title_full | SLC26 family: a new insight for kidney stone disease |
| title_fullStr | SLC26 family: a new insight for kidney stone disease |
| title_full_unstemmed | SLC26 family: a new insight for kidney stone disease |
| title_short | SLC26 family: a new insight for kidney stone disease |
| title_sort | slc26 family a new insight for kidney stone disease |
| topic | SLC26 kidney stone oxalate hyperoxaluria oxalate metabolism |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1118342/full |
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