Initial experience and outcomes with a hybrid extracorporeal membrane oxygenation and cardiopulmonary bypass circuit for lung transplantationCentral MessagePerspective
Background: The utilization of extracorporeal life support (ECLS) for intraoperative support during lung transplantation has increased over the past decade. Although veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has recently emerged as the preferred modality over cardiopulmonary bypass...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | JTCVS Open |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666273623003066 |
| _version_ | 1797385037791887360 |
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| author | Archer Kilbourne Martin, MD Ashley Virginia Fritz, DO Si M. Pham, MD Kevin P. Landolfo, MD, MS Basar Sareyyupoglu, MD Thomas E. Brown, CCP Ilana Logvinov, DNP Zhuo Li, MS Tathagat Narula, MD Ian A. Makey, MD Mathew Thomas, MBBS, MD |
| author_facet | Archer Kilbourne Martin, MD Ashley Virginia Fritz, DO Si M. Pham, MD Kevin P. Landolfo, MD, MS Basar Sareyyupoglu, MD Thomas E. Brown, CCP Ilana Logvinov, DNP Zhuo Li, MS Tathagat Narula, MD Ian A. Makey, MD Mathew Thomas, MBBS, MD |
| author_sort | Archer Kilbourne Martin, MD |
| collection | DOAJ |
| description | Background: The utilization of extracorporeal life support (ECLS) for intraoperative support during lung transplantation has increased over the past decade. Although veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has recently emerged as the preferred modality over cardiopulmonary bypass (CPB), many centers continue to use both forms of ECLS during lung transplantation. Our novel hybrid VA-ECMO/CPB circuit allows for seamless transition from VA-ECMO to CPB at a significant cost savings compared to a standalone VA-ECMO circuit. This study describes our initial experience and outcomes in the first 100 bilateral lung transplantations using this novel hybrid VA-ECMO/CPB circuit. Methods: Medical records from September 2017 to May 2021 of the first 100 consecutive patients undergoing bilateral lung transplantation with intraoperative hybrid VA-ECMO support were examined retrospectively. We excluded patients with single lung transplants, retransplantations, preoperative ECLS bridging, and veno-venous (VV) ECMO and those supported with CPB only. Perioperative recipient, anesthetic, perfusion variables, and outcomes were assessed. Results: Of the 100 patients supported with VA-ECMO, 19 were converted intraoperatively to CPB. Right ventricular dysfunction was seen in 37% of patients, and the median mean pulmonary artery pressure was 28 mm Hg. No oxygenator clotting was observed with a median heparin dose of 13,000 units in the VA-ECMO group. Primary graft dysfunction grade 3 at 72 hours was observed in 10.1% of all patients and observed 1-year mortality was 4%. Conclusions: The use of a hybrid VA-ECMO/CPB circuit in our institution allows for rapid conversion to CPB with acceptable outcomes across a diverse recipient group at a significantly reduced cost compared to standalone VA-ECMO circuits. |
| first_indexed | 2024-03-08T21:48:21Z |
| format | Article |
| id | doaj.art-aae82903e49348f18f14de35186c4d15 |
| institution | Directory Open Access Journal |
| issn | 2666-2736 |
| language | English |
| last_indexed | 2024-03-08T21:48:21Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JTCVS Open |
| spelling | doaj.art-aae82903e49348f18f14de35186c4d152023-12-20T07:38:20ZengElsevierJTCVS Open2666-27362023-12-011610291037Initial experience and outcomes with a hybrid extracorporeal membrane oxygenation and cardiopulmonary bypass circuit for lung transplantationCentral MessagePerspectiveArcher Kilbourne Martin, MD0Ashley Virginia Fritz, DO1Si M. Pham, MD2Kevin P. Landolfo, MD, MS3Basar Sareyyupoglu, MD4Thomas E. Brown, CCP5Ilana Logvinov, DNP6Zhuo Li, MS7Tathagat Narula, MD8Ian A. Makey, MD9Mathew Thomas, MBBS, MD10Division of Cardiovascular and Thoracic Anesthesiology, Mayo Clinic Florida, Jacksonville, Fla; Address for reprints: Archer Kilbourne Martin, MD, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224.Division of Cardiovascular and Thoracic Anesthesiology, Mayo Clinic Florida, Jacksonville, FlaDepartment of Cardiothoracic Surgery, Mayo Clinic Florida, Jacksonville, FlaDepartment of Cardiothoracic Surgery, Mayo Clinic Florida, Jacksonville, FlaDepartment of Cardiothoracic Surgery, Mayo Clinic Florida, Jacksonville, FlaDepartment of Cardiothoracic Surgery, Mayo Clinic Florida, Jacksonville, FlaDivision of Cardiovascular and Thoracic Anesthesiology, Mayo Clinic Florida, Jacksonville, FlaDepartment of Clinical Trials and Biostatistics, Mayo Clinic Florida, Jacksonville, FlaDivision of Lung Failure and Transplant, Mayo Clinic Florida, Jacksonville, FlaDepartment of Cardiothoracic Surgery, Mayo Clinic Florida, Jacksonville, FlaDepartment of Cardiothoracic Surgery, Mayo Clinic Florida, Jacksonville, FlaBackground: The utilization of extracorporeal life support (ECLS) for intraoperative support during lung transplantation has increased over the past decade. Although veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has recently emerged as the preferred modality over cardiopulmonary bypass (CPB), many centers continue to use both forms of ECLS during lung transplantation. Our novel hybrid VA-ECMO/CPB circuit allows for seamless transition from VA-ECMO to CPB at a significant cost savings compared to a standalone VA-ECMO circuit. This study describes our initial experience and outcomes in the first 100 bilateral lung transplantations using this novel hybrid VA-ECMO/CPB circuit. Methods: Medical records from September 2017 to May 2021 of the first 100 consecutive patients undergoing bilateral lung transplantation with intraoperative hybrid VA-ECMO support were examined retrospectively. We excluded patients with single lung transplants, retransplantations, preoperative ECLS bridging, and veno-venous (VV) ECMO and those supported with CPB only. Perioperative recipient, anesthetic, perfusion variables, and outcomes were assessed. Results: Of the 100 patients supported with VA-ECMO, 19 were converted intraoperatively to CPB. Right ventricular dysfunction was seen in 37% of patients, and the median mean pulmonary artery pressure was 28 mm Hg. No oxygenator clotting was observed with a median heparin dose of 13,000 units in the VA-ECMO group. Primary graft dysfunction grade 3 at 72 hours was observed in 10.1% of all patients and observed 1-year mortality was 4%. Conclusions: The use of a hybrid VA-ECMO/CPB circuit in our institution allows for rapid conversion to CPB with acceptable outcomes across a diverse recipient group at a significantly reduced cost compared to standalone VA-ECMO circuits.http://www.sciencedirect.com/science/article/pii/S2666273623003066extracorporeal membrane oxygenationlung transplantationmechanical circulatory supportcardiothoracic transplantation |
| spellingShingle | Archer Kilbourne Martin, MD Ashley Virginia Fritz, DO Si M. Pham, MD Kevin P. Landolfo, MD, MS Basar Sareyyupoglu, MD Thomas E. Brown, CCP Ilana Logvinov, DNP Zhuo Li, MS Tathagat Narula, MD Ian A. Makey, MD Mathew Thomas, MBBS, MD Initial experience and outcomes with a hybrid extracorporeal membrane oxygenation and cardiopulmonary bypass circuit for lung transplantationCentral MessagePerspective JTCVS Open extracorporeal membrane oxygenation lung transplantation mechanical circulatory support cardiothoracic transplantation |
| title | Initial experience and outcomes with a hybrid extracorporeal membrane oxygenation and cardiopulmonary bypass circuit for lung transplantationCentral MessagePerspective |
| title_full | Initial experience and outcomes with a hybrid extracorporeal membrane oxygenation and cardiopulmonary bypass circuit for lung transplantationCentral MessagePerspective |
| title_fullStr | Initial experience and outcomes with a hybrid extracorporeal membrane oxygenation and cardiopulmonary bypass circuit for lung transplantationCentral MessagePerspective |
| title_full_unstemmed | Initial experience and outcomes with a hybrid extracorporeal membrane oxygenation and cardiopulmonary bypass circuit for lung transplantationCentral MessagePerspective |
| title_short | Initial experience and outcomes with a hybrid extracorporeal membrane oxygenation and cardiopulmonary bypass circuit for lung transplantationCentral MessagePerspective |
| title_sort | initial experience and outcomes with a hybrid extracorporeal membrane oxygenation and cardiopulmonary bypass circuit for lung transplantationcentral messageperspective |
| topic | extracorporeal membrane oxygenation lung transplantation mechanical circulatory support cardiothoracic transplantation |
| url | http://www.sciencedirect.com/science/article/pii/S2666273623003066 |
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