Relationship Between Estimated Glucose Disposal Rate and Type 2 Diabetic Retinopathy
Cuiqiao Meng,1 Yuling Xing,2,3 Lijing Huo,4 Huijuan Ma2,5,6 1Health Examination Center, Hebei General Hospital, Shijiazhuang, People’s Republic of China; 2Department of Endocrinology, Hebei General Hospital, Shijiazhuang, People’s Republic of China; 3Graduate School of Hebei Medical University, Shij...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-03-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
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| Online Access: | https://www.dovepress.com/relationship-between-estimated-glucose-disposal-rate-and-type-2-diabet-peer-reviewed-fulltext-article-DMSO |
| _version_ | 1797869148574842880 |
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| author | Meng C Xing Y Huo L Ma H |
| author_facet | Meng C Xing Y Huo L Ma H |
| author_sort | Meng C |
| collection | DOAJ |
| description | Cuiqiao Meng,1 Yuling Xing,2,3 Lijing Huo,4 Huijuan Ma2,5,6 1Health Examination Center, Hebei General Hospital, Shijiazhuang, People’s Republic of China; 2Department of Endocrinology, Hebei General Hospital, Shijiazhuang, People’s Republic of China; 3Graduate School of Hebei Medical University, Shijiazhuang, People’s Republic of China; 4Department of Clinical Laboratory, Hebei General Hospital, Shijiazhuang, People’s Republic of China; 5Hebei Key Laboratory of Metabolic Diseases, Hebei General Hospital, Shijiazhuang, Hebei, People’s Republic of China; 6Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of ChinaCorrespondence: Huijuan Ma, Department of Endocrinology, Hebei General Hospital, Shijiazhuang, 050051, People’s Republic of China, Tel +86 18032838686, Email huijuanma76@163.comPurpose: To investigate the association between diabetic retinopathy (DR), DR intensity, and estimated glucose disposal rate (eGDR) in individuals with type 2 diabetes mellitus (T2DM).Patients and Methods: This study comprised 1762 T2DM patients who were admitted between January and December, 2021. Overall, the DR was identified in 430 patients. Based on the eGDR, the participants were divided into four study groups. One-way analysis of variance was used to compare the groups. The correlations between eGDR and DR risk, eGDR, and DR severity were analyzed using regression analysis. Furthermore, these relationships were analyzed in different sex groups.Results: Patients with T2DM had a 19.75% (348/1762) DR detection rate, whereas those with DR had a 22.41% (78/348) proliferative DR detection rate. The DR group had substantially reduced levels of eGDR compared with the non-DR group. Multivariate logistic regression analysis demonstrated that reduced eGDR was an independent risk factor for DR, after adjusting for confounding variables. eGDR correlated significantly with proliferative DR in women but not in men.Conclusion: In Chinese individuals with T2DM, lower eGDR was independently associated with a higher risk of DR.Keywords: estimated glucose disposal rate, type 2 diabetes mellitus, diabetic retinopathy |
| first_indexed | 2024-04-10T00:08:05Z |
| format | Article |
| id | doaj.art-aae96501aa6f421c99ea7d99378820fe |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T00:08:05Z |
| publishDate | 2023-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-aae96501aa6f421c99ea7d99378820fe2023-03-16T18:09:45ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072023-03-01Volume 1680781882335Relationship Between Estimated Glucose Disposal Rate and Type 2 Diabetic RetinopathyMeng CXing YHuo LMa HCuiqiao Meng,1 Yuling Xing,2,3 Lijing Huo,4 Huijuan Ma2,5,6 1Health Examination Center, Hebei General Hospital, Shijiazhuang, People’s Republic of China; 2Department of Endocrinology, Hebei General Hospital, Shijiazhuang, People’s Republic of China; 3Graduate School of Hebei Medical University, Shijiazhuang, People’s Republic of China; 4Department of Clinical Laboratory, Hebei General Hospital, Shijiazhuang, People’s Republic of China; 5Hebei Key Laboratory of Metabolic Diseases, Hebei General Hospital, Shijiazhuang, Hebei, People’s Republic of China; 6Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of ChinaCorrespondence: Huijuan Ma, Department of Endocrinology, Hebei General Hospital, Shijiazhuang, 050051, People’s Republic of China, Tel +86 18032838686, Email huijuanma76@163.comPurpose: To investigate the association between diabetic retinopathy (DR), DR intensity, and estimated glucose disposal rate (eGDR) in individuals with type 2 diabetes mellitus (T2DM).Patients and Methods: This study comprised 1762 T2DM patients who were admitted between January and December, 2021. Overall, the DR was identified in 430 patients. Based on the eGDR, the participants were divided into four study groups. One-way analysis of variance was used to compare the groups. The correlations between eGDR and DR risk, eGDR, and DR severity were analyzed using regression analysis. Furthermore, these relationships were analyzed in different sex groups.Results: Patients with T2DM had a 19.75% (348/1762) DR detection rate, whereas those with DR had a 22.41% (78/348) proliferative DR detection rate. The DR group had substantially reduced levels of eGDR compared with the non-DR group. Multivariate logistic regression analysis demonstrated that reduced eGDR was an independent risk factor for DR, after adjusting for confounding variables. eGDR correlated significantly with proliferative DR in women but not in men.Conclusion: In Chinese individuals with T2DM, lower eGDR was independently associated with a higher risk of DR.Keywords: estimated glucose disposal rate, type 2 diabetes mellitus, diabetic retinopathyhttps://www.dovepress.com/relationship-between-estimated-glucose-disposal-rate-and-type-2-diabet-peer-reviewed-fulltext-article-DMSOestimated glucose disposal ratetype 2 diabetes mellitusdiabetic retinopathy |
| spellingShingle | Meng C Xing Y Huo L Ma H Relationship Between Estimated Glucose Disposal Rate and Type 2 Diabetic Retinopathy Diabetes, Metabolic Syndrome and Obesity estimated glucose disposal rate type 2 diabetes mellitus diabetic retinopathy |
| title | Relationship Between Estimated Glucose Disposal Rate and Type 2 Diabetic Retinopathy |
| title_full | Relationship Between Estimated Glucose Disposal Rate and Type 2 Diabetic Retinopathy |
| title_fullStr | Relationship Between Estimated Glucose Disposal Rate and Type 2 Diabetic Retinopathy |
| title_full_unstemmed | Relationship Between Estimated Glucose Disposal Rate and Type 2 Diabetic Retinopathy |
| title_short | Relationship Between Estimated Glucose Disposal Rate and Type 2 Diabetic Retinopathy |
| title_sort | relationship between estimated glucose disposal rate and type 2 diabetic retinopathy |
| topic | estimated glucose disposal rate type 2 diabetes mellitus diabetic retinopathy |
| url | https://www.dovepress.com/relationship-between-estimated-glucose-disposal-rate-and-type-2-diabet-peer-reviewed-fulltext-article-DMSO |
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