A Miniature Probe for Ultrasonic Penetration of a Single Cell
Although ultrasound cavitation must be avoided for safe diagnostic applications, the ability of ultrasound to disrupt cell membranes has taken on increasing significance as a method to facilitate drug and gene delivery. A new ultrasonic resonance driving method is introduced to penetrate rigid wall...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2009-05-01
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| Series: | Sensors |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1424-8220/9/5/3325/ |
| _version_ | 1828136388558585856 |
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| author | Mingfei Xiao Qun Wang Xing Yang Zhaoying Zhou Ting Wu |
| author_facet | Mingfei Xiao Qun Wang Xing Yang Zhaoying Zhou Ting Wu |
| author_sort | Mingfei Xiao |
| collection | DOAJ |
| description | Although ultrasound cavitation must be avoided for safe diagnostic applications, the ability of ultrasound to disrupt cell membranes has taken on increasing significance as a method to facilitate drug and gene delivery. A new ultrasonic resonance driving method is introduced to penetrate rigid wall plant cells or oocytes with springy cell membranes. When a reasonable design is created, ultrasound can gather energy and increase the amplitude factor. Ultrasonic penetration enables exogenous materials to enter cells without damaging them by utilizing instant acceleration. This paper seeks to develop a miniature ultrasonic probe experiment system for cell penetration. A miniature ultrasonic probe is designed and optimized using the Precise Four Terminal Network Method and Finite Element Method (FEM) and an ultrasonic generator to drive the probe is designed. The system was able to successfully puncture a single fish cell. |
| first_indexed | 2024-04-11T18:02:19Z |
| format | Article |
| id | doaj.art-aae9909f96774f9885df311ea5ac5ea5 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-11T18:02:19Z |
| publishDate | 2009-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-aae9909f96774f9885df311ea5ac5ea52022-12-22T04:10:26ZengMDPI AGSensors1424-82202009-05-01953325333610.3390/s90503325A Miniature Probe for Ultrasonic Penetration of a Single CellMingfei XiaoQun WangXing YangZhaoying ZhouTing WuAlthough ultrasound cavitation must be avoided for safe diagnostic applications, the ability of ultrasound to disrupt cell membranes has taken on increasing significance as a method to facilitate drug and gene delivery. A new ultrasonic resonance driving method is introduced to penetrate rigid wall plant cells or oocytes with springy cell membranes. When a reasonable design is created, ultrasound can gather energy and increase the amplitude factor. Ultrasonic penetration enables exogenous materials to enter cells without damaging them by utilizing instant acceleration. This paper seeks to develop a miniature ultrasonic probe experiment system for cell penetration. A miniature ultrasonic probe is designed and optimized using the Precise Four Terminal Network Method and Finite Element Method (FEM) and an ultrasonic generator to drive the probe is designed. The system was able to successfully puncture a single fish cell.http://www.mdpi.com/1424-8220/9/5/3325/Ultrasonic penetrationFEMultrasonic probecellgenerator |
| spellingShingle | Mingfei Xiao Qun Wang Xing Yang Zhaoying Zhou Ting Wu A Miniature Probe for Ultrasonic Penetration of a Single Cell Sensors Ultrasonic penetration FEM ultrasonic probe cell generator |
| title | A Miniature Probe for Ultrasonic Penetration of a Single Cell |
| title_full | A Miniature Probe for Ultrasonic Penetration of a Single Cell |
| title_fullStr | A Miniature Probe for Ultrasonic Penetration of a Single Cell |
| title_full_unstemmed | A Miniature Probe for Ultrasonic Penetration of a Single Cell |
| title_short | A Miniature Probe for Ultrasonic Penetration of a Single Cell |
| title_sort | miniature probe for ultrasonic penetration of a single cell |
| topic | Ultrasonic penetration FEM ultrasonic probe cell generator |
| url | http://www.mdpi.com/1424-8220/9/5/3325/ |
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