Clinical Parameters and Epigenetic Biomarkers of Plaque Vulnerability in Patients with Carotid Stenosis
Atheromatous disease is the first cause of death and dependency in developed countries and carotid artery atherosclerosis is one of the main causes of severe ischaemic strokes. Current management strategies are mainly based on the degree of stenosis and patient selection has limited accuracy. This i...
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MDPI AG
2022-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/9/5149 |
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| author | Laia Carballo-Perich Dolors Puigoriol-Illamola Saima Bashir Mikel Terceño Yolanda Silva Carme Gubern-Mérida Joaquín Serena |
| author_facet | Laia Carballo-Perich Dolors Puigoriol-Illamola Saima Bashir Mikel Terceño Yolanda Silva Carme Gubern-Mérida Joaquín Serena |
| author_sort | Laia Carballo-Perich |
| collection | DOAJ |
| description | Atheromatous disease is the first cause of death and dependency in developed countries and carotid artery atherosclerosis is one of the main causes of severe ischaemic strokes. Current management strategies are mainly based on the degree of stenosis and patient selection has limited accuracy. This information could be complemented by the identification of biomarkers of plaque vulnerability, which would permit patients at greater and lesser risk of stroke to be distinguished, thus enabling a better selection of patients for surgical or intensive medical treatment. Although several circulating protein-based biomarkers with significance for both the diagnosis of carotid artery disease and its prognosis have been identified, at present, none have been clinically implemented. This review focuses especially on the most relevant clinical parameters to take into account in routine clinical practice and summarises the most up-to-date data on epigenetic biomarkers of carotid atherosclerosis and plaque vulnerability. |
| first_indexed | 2024-03-10T04:03:32Z |
| format | Article |
| id | doaj.art-aaeb7523a86e47cfa3e8c7bda9eae7ac |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T04:03:32Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-aaeb7523a86e47cfa3e8c7bda9eae7ac2023-11-23T08:27:50ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-05-01239514910.3390/ijms23095149Clinical Parameters and Epigenetic Biomarkers of Plaque Vulnerability in Patients with Carotid StenosisLaia Carballo-Perich0Dolors Puigoriol-Illamola1Saima Bashir2Mikel Terceño3Yolanda Silva4Carme Gubern-Mérida5Joaquín Serena6Cerebrovascular Pathology Research Group, Girona Biomedical Research Institute (IDIBGI), RICORS-ICTUS, Parc Hospitalari Martí I Julià, Edifici M2, 17190 Salt, SpainCerebrovascular Pathology Research Group, Girona Biomedical Research Institute (IDIBGI), RICORS-ICTUS, Parc Hospitalari Martí I Julià, Edifici M2, 17190 Salt, SpainCerebrovascular Pathology Research Group, Stroke Unit, Department of Neurology, Girona Biomedical Research Institute (IDIBGI), Dr. Josep Trueta University Hospital, RICORS-ICTUS, Av. França s/n (7a Planta), 17007 Girona, SpainCerebrovascular Pathology Research Group, Stroke Unit, Department of Neurology, Girona Biomedical Research Institute (IDIBGI), Dr. Josep Trueta University Hospital, RICORS-ICTUS, Av. França s/n (7a Planta), 17007 Girona, SpainCerebrovascular Pathology Research Group, Stroke Unit, Department of Neurology, Girona Biomedical Research Institute (IDIBGI), Dr. Josep Trueta University Hospital, RICORS-ICTUS, Av. França s/n (7a Planta), 17007 Girona, SpainCerebrovascular Pathology Research Group, Girona Biomedical Research Institute (IDIBGI), RICORS-ICTUS, Parc Hospitalari Martí I Julià, Edifici M2, 17190 Salt, SpainCerebrovascular Pathology Research Group, Stroke Unit, Department of Neurology, Girona Biomedical Research Institute (IDIBGI), Dr. Josep Trueta University Hospital, RICORS-ICTUS, Av. França s/n (7a Planta), 17007 Girona, SpainAtheromatous disease is the first cause of death and dependency in developed countries and carotid artery atherosclerosis is one of the main causes of severe ischaemic strokes. Current management strategies are mainly based on the degree of stenosis and patient selection has limited accuracy. This information could be complemented by the identification of biomarkers of plaque vulnerability, which would permit patients at greater and lesser risk of stroke to be distinguished, thus enabling a better selection of patients for surgical or intensive medical treatment. Although several circulating protein-based biomarkers with significance for both the diagnosis of carotid artery disease and its prognosis have been identified, at present, none have been clinically implemented. This review focuses especially on the most relevant clinical parameters to take into account in routine clinical practice and summarises the most up-to-date data on epigenetic biomarkers of carotid atherosclerosis and plaque vulnerability.https://www.mdpi.com/1422-0067/23/9/5149biomarkercarotid artery stenosisstrokeneuroimagingepigeneticsvulnerable plaque |
| spellingShingle | Laia Carballo-Perich Dolors Puigoriol-Illamola Saima Bashir Mikel Terceño Yolanda Silva Carme Gubern-Mérida Joaquín Serena Clinical Parameters and Epigenetic Biomarkers of Plaque Vulnerability in Patients with Carotid Stenosis International Journal of Molecular Sciences biomarker carotid artery stenosis stroke neuroimaging epigenetics vulnerable plaque |
| title | Clinical Parameters and Epigenetic Biomarkers of Plaque Vulnerability in Patients with Carotid Stenosis |
| title_full | Clinical Parameters and Epigenetic Biomarkers of Plaque Vulnerability in Patients with Carotid Stenosis |
| title_fullStr | Clinical Parameters and Epigenetic Biomarkers of Plaque Vulnerability in Patients with Carotid Stenosis |
| title_full_unstemmed | Clinical Parameters and Epigenetic Biomarkers of Plaque Vulnerability in Patients with Carotid Stenosis |
| title_short | Clinical Parameters and Epigenetic Biomarkers of Plaque Vulnerability in Patients with Carotid Stenosis |
| title_sort | clinical parameters and epigenetic biomarkers of plaque vulnerability in patients with carotid stenosis |
| topic | biomarker carotid artery stenosis stroke neuroimaging epigenetics vulnerable plaque |
| url | https://www.mdpi.com/1422-0067/23/9/5149 |
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