Liquid dynamic medicine and N-of-1 clinical trials: a change of perspective in oncology research
Abstract The increasing use of genomics to define the pattern of actionable mutations and to test and validate new therapies for individual cancer patients, and the growing application of liquid biopsy to dynamically track tumor evolution and to adapt molecularly targeted therapy according to the em...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-09-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13046-017-0598-x |
| _version_ | 1811331232035766272 |
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| author | Nicola Silvestris Gennaro Ciliberto Paolo De Paoli Giovanni Apolone Maria Luisa Lavitrano Marco A. Pierotti Giorgio Stanta On the behalf of the “dynamic medicine OECI group” |
| author_facet | Nicola Silvestris Gennaro Ciliberto Paolo De Paoli Giovanni Apolone Maria Luisa Lavitrano Marco A. Pierotti Giorgio Stanta On the behalf of the “dynamic medicine OECI group” |
| author_sort | Nicola Silvestris |
| collection | DOAJ |
| description | Abstract The increasing use of genomics to define the pattern of actionable mutations and to test and validate new therapies for individual cancer patients, and the growing application of liquid biopsy to dynamically track tumor evolution and to adapt molecularly targeted therapy according to the emergence of tumor clonal variants is shaping modern medical oncology., In order to better describe this new therapeutic paradigm we propose the term “Liquid dynamic medicine” in the place of “Personalized or Precision medicine”. Clinical validation of the “Liquid dynamic medicine” approach is best captured by N-of-1 trials where each patient acts as tester and control of truly personalized therapies. |
| first_indexed | 2024-04-13T16:16:28Z |
| format | Article |
| id | doaj.art-aaed13d6eead4f4995b4651c81c4cf37 |
| institution | Directory Open Access Journal |
| issn | 1756-9966 |
| language | English |
| last_indexed | 2024-04-13T16:16:28Z |
| publishDate | 2017-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj.art-aaed13d6eead4f4995b4651c81c4cf372022-12-22T02:40:03ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662017-09-013611510.1186/s13046-017-0598-xLiquid dynamic medicine and N-of-1 clinical trials: a change of perspective in oncology researchNicola Silvestris0Gennaro Ciliberto1Paolo De Paoli2Giovanni Apolone3Maria Luisa Lavitrano4Marco A. Pierotti5Giorgio Stanta6On the behalf of the “dynamic medicine OECI group”Medical Oncology Unit and Scientific Directorate, Cancer Institute “Giovanni Paolo II”Scientific Directorate, IRCCS National Cancer Institute “Regina Elena”Scientific Directorate, IRCCS “Centro di Riferimento Oncologico”Scientific Directorate, Fondazione IRCCS Istituto Nazionale dei TumoriBBMRI.it and Department of Medicine and Surgery University Milano-BicoccaSenior Group Leader Foundation Institute FIRC Molecular Oncology (IFOM) MilanDepartment of Medical Sciences of the University of TriesteAbstract The increasing use of genomics to define the pattern of actionable mutations and to test and validate new therapies for individual cancer patients, and the growing application of liquid biopsy to dynamically track tumor evolution and to adapt molecularly targeted therapy according to the emergence of tumor clonal variants is shaping modern medical oncology., In order to better describe this new therapeutic paradigm we propose the term “Liquid dynamic medicine” in the place of “Personalized or Precision medicine”. Clinical validation of the “Liquid dynamic medicine” approach is best captured by N-of-1 trials where each patient acts as tester and control of truly personalized therapies.http://link.springer.com/article/10.1186/s13046-017-0598-xDynamicFluidPersonalized medicineTarget therapyClinical trialsN-of-1 trials |
| spellingShingle | Nicola Silvestris Gennaro Ciliberto Paolo De Paoli Giovanni Apolone Maria Luisa Lavitrano Marco A. Pierotti Giorgio Stanta On the behalf of the “dynamic medicine OECI group” Liquid dynamic medicine and N-of-1 clinical trials: a change of perspective in oncology research Journal of Experimental & Clinical Cancer Research Dynamic Fluid Personalized medicine Target therapy Clinical trials N-of-1 trials |
| title | Liquid dynamic medicine and N-of-1 clinical trials: a change of perspective in oncology research |
| title_full | Liquid dynamic medicine and N-of-1 clinical trials: a change of perspective in oncology research |
| title_fullStr | Liquid dynamic medicine and N-of-1 clinical trials: a change of perspective in oncology research |
| title_full_unstemmed | Liquid dynamic medicine and N-of-1 clinical trials: a change of perspective in oncology research |
| title_short | Liquid dynamic medicine and N-of-1 clinical trials: a change of perspective in oncology research |
| title_sort | liquid dynamic medicine and n of 1 clinical trials a change of perspective in oncology research |
| topic | Dynamic Fluid Personalized medicine Target therapy Clinical trials N-of-1 trials |
| url | http://link.springer.com/article/10.1186/s13046-017-0598-x |
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