Unfolded protein stress in the endoplasmic reticulum and mitochondria: a role in neurodegeneration

Unfolded protein stress in the endoplasmic reticulum and mitochondria: a role in neurodegeneration

Protein folding occurs in several intracellular locations including the endoplasmic reticulum (ER) and mitochondria. In normal conditions there is a balance between the levels of unfolded proteins and protein folding machinery. Disruption of homeostasis and an accumulation of unfolded proteins trigg...

Full description

Bibliographic Details
Main Authors:	Sebastián eBernales, Marisol Andrea Morales Soto, Emma eMcCullagh
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2012-04-01
Series:	Frontiers in Aging Neuroscience
Subjects:	Endoplasmic Reticulum Mitochondria Unfolded Protein Response Parkinson’s disease neurodegeneration Alzheimer’s disease
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fnagi.2012.00005/full

Similar Items

Miga-mediated endoplasmic reticulum–mitochondria contact sites regulate neuronal homeostasis
by: Lingna Xu, et al.
Published: (2020-07-01)

Endoplasmic Reticulum–Mitochondria Contact Sites and Neurodegeneration
by: Lingna Xu, et al.
Published: (2020-06-01)

The Endoplasmic Reticulum Stress/Unfolded Protein Response and Their Contributions to Parkinson’s Disease Physiopathology
by: Cristine Alves da Costa, et al.
Published: (2020-11-01)

Structural and Functional Significance of the Endoplasmic Reticulum Unfolded Protein Response Transducers and Chaperones at the Mitochondria–ER Contacts: A Cancer Perspective
by: Giuseppina Amodio, et al.
Published: (2021-03-01)

Morphological Heterogeneity of the Endoplasmic Reticulum within Neurons and Its Implications in Neurodegeneration
by: Sreesha Sree, et al.
Published: (2021-04-01)

Endoplasmic reticulum stress and inflammation in the central nervous system
by: Neil T. Sprenkle, et al.
Published: (2017-05-01)

Unfolding the Interactions between Endoplasmic Reticulum Stress and Oxidative Stress
by: Gideon Ong, et al.
Published: (2023-04-01)

The Potential of Small Molecules to Modulate the Mitochondria–Endoplasmic Reticulum Interplay in Alzheimer’s Disease
by: Giacomo Dentoni, et al.
Published: (2022-08-01)

STING, the Endoplasmic Reticulum, and Mitochondria: Is Three a Crowd or a Conversation?
by: Judith A. Smith
Published: (2021-01-01)

Unfolding the Endoplasmic Reticulum of a Social Amoeba: Dictyostelium discoideum as a New Model for the Study of Endoplasmic Reticulum Stress
by: Eunice Domínguez-Martín, et al.
Published: (2018-06-01)

Endoplasmic Reticulum Stress Coping Mechanisms and Lifespan Regulation in Health and Diseases
by: Sarah R. Chadwick, et al.
Published: (2019-05-01)

The Molecular Mechanisms Underlying Mitochondria-Associated Endoplasmic Reticulum Membrane-Induced Insulin Resistance
by: Han Cheng, et al.
Published: (2020-11-01)

Endoplasmic Reticulum Unfolded Protein Response, Aging and Exercise: An Update
by: Brisamar Estébanez, et al.
Published: (2018-12-01)

Chemical Modulation of Mitochondria–Endoplasmic Reticulum Contact Sites
by: Ana Paula Magalhães Rebelo, et al.
Published: (2020-07-01)

Communications between Mitochondria and Endoplasmic Reticulum in the Regulation of Metabolic Homeostasis
by: Pengcheng Zhang, et al.
Published: (2021-08-01)

Editorial: Mitochondria and Endoplasmic Reticulum Dysfunction in Parkinson’s Disease
by: Sandeep Kumar Barodia, et al.
Published: (2019-11-01)

Zearalenone induces mitochondria-associated endoplasmic reticulum membranes dysfunction in piglet Sertoli cells based on endoplasmic reticulum stress
by: Li Ma, et al.
Published: (2023-04-01)

Disruption of endoplasmic reticulum-mitochondria tethering proteins in post-mortem Alzheimer's disease brain
by: Dawn H.W. Lau, et al.
Published: (2020-09-01)

Mitochondria-Associated Endoplasmic Reticulum Membranes in the Pathogenesis of Type 2 Diabetes Mellitus
by: Shanshan Yang, et al.
Published: (2020-10-01)

Endoplasmic Reticulum and Mitochondria Contacts Correlate with the Presence and Severity of NASH in Humans
by: Chaonan Jin, et al.
Published: (2022-07-01)

Editorial: Recent advances in mitochondria-associated endoplasmic reticulum membranes (MAMs) in heart-related diseases
by: Yang Yang, et al.
Published: (2023-03-01)

Metabolic interplay between peroxisomes and other subcellular organelles including mitochondria and the endoplasmic reticulum
by: Ronald J.A. Wanders, et al.
Published: (2016-01-01)

Stress responses from the endoplasmic reticulum in cancer
by: Hironori eKato, et al.
Published: (2015-04-01)

Unfolded protein response activated by endoplasmic reticulum stress in pancreatic cancer: potential therapeutical target
by: Di Long, et al.
Published: (2021-12-01)

Forcing contacts between mitochondria and the endoplasmic reticulum extends lifespan in a Drosophila model of Alzheimer's disease
by: Juan Garrido-Maraver, et al.
Published: (2020-01-01)

A Pipeline for Natural Small Molecule Inhibitors of Endoplasmic Reticulum Stress
by: Daniela Correia da Silva, et al.
Published: (2022-07-01)

Endoplasmic Reticulum Stress, Unfolded Protein Response, and Cancer Cell Fate
by: Marco Corazzari, et al.
Published: (2017-04-01)

Editorial: Regulation of endoplasmic reticulum and mitochondria in cellular homeostasis
by: Yongye Huang, et al.
Published: (2022-08-01)

The Unfolded Protein Response: A Double-Edged Sword for Brain Health
by: Magdalena Gebert, et al.
Published: (2023-08-01)

Homocysteine activates T cells by enhancing endoplasmic reticulum-mitochondria coupling and increasing mitochondrial respiration
by: Juan Feng, et al.
Published: (2016-02-01)

The contribution of mitochondria-associated endoplasmic reticulum membranes (MAMs) dysfunction in Alzheimer’s disease and the potential countermeasure
by: Zehui Li, et al.
Published: (2023-03-01)

The Mitochondria–Endoplasmic Reticulum Contacts and Their Critical Role in Aging and Age-Associated Diseases
by: Ornella Moltedo, et al.
Published: (2019-08-01)

Chlorpromazine induces cytotoxic autophagy in glioblastoma cells via endoplasmic reticulum stress and unfolded protein response
by: Silvia Matteoni, et al.
Published: (2021-11-01)

Salivary Histatin 1 and 2 Are Targeted to Mitochondria and Endoplasmic Reticulum in Human Cells
by: Dandan Ma, et al.
Published: (2020-03-01)

Endoplasmic Reticulum Stress Signaling and Neuronal Cell Death
by: Adalberto Merighi, et al.
Published: (2022-12-01)

Chemical Chaperones to Inhibit Endoplasmic Reticulum Stress: Implications in Diseases
by: Jeon JH, et al.
Published: (2022-12-01)

Endoplasmic Reticulum Stress Signaling and the Pathogenesis of Hepatocarcinoma
by: Juncheng Wei, et al.
Published: (2021-02-01)

INVESTIGATION OF ENDOPLASMIC RETICULUM SIGNAL PROTEINS IN CUMULUS CELLS WITH NORMAL,HYPERRESPONSIVE,HYPORESPONSIVE AND POLYCYSTIC OVARY SYNDROMES
by: Bahar KARTAL
Published: (2019-08-01)

Cancer: Untethering Mitochondria from the Endoplasmic Reticulum?
by: Maria Sol Herrera-Cruz, et al.
Published: (2017-05-01)

Current Status of Endoplasmic Reticulum Stress in Type II Diabetes
by: Sagir Mustapha, et al.
Published: (2021-07-01)