Endoproteolysis of cellular prion protein by plasmin hinders propagation of prions

Endoproteolysis of cellular prion protein by plasmin hinders propagation of prions

Many questions surround the underlying mechanism for the differential metabolic processing observed for the prion protein (PrP) in healthy and prion-infected mammals. Foremost, the physiological α-cleavage of PrP interrupts a region critical for both toxicity and conversion of cellular PrP (PrPC) in...

Full description

Bibliographic Details
Main Authors: Charles E. Mays, Trang H. T. Trinh, Glenn Telling, Hae-Eun Kang, Chongsuk Ryou
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
plasmin
prion
endoproteolysis
α-cleavage
PrPSc propagation
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.990136/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2022.990136/full

Similar Items