A Histopathological Study of the Small Intestinal Lesions
Introduction: Frequently received specimens of small intestine are non-neoplastic diseases like Crohn’s, ischemic enteritis, non-specific enteritis, tuberculosis and neoplastic diseases like adenomas and carcinomas. Clinical and radiological findings are non specific and histopathological study...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Pvt. Ltd.
2017-04-01
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| Series: | National Journal of Laboratory Medicine |
| Subjects: | |
| Online Access: | http://www.njlm.net/articles/PDF/2217/24952_CE[VSU]_F(GH)_PF1(VsuGH)_PFA(GH)_PF2(VsuGH).pdf |
| Summary: | Introduction: Frequently received specimens of small intestine
are non-neoplastic diseases like Crohn’s, ischemic enteritis,
non-specific enteritis, tuberculosis and neoplastic diseases like
adenomas and carcinomas. Clinical and radiological findings
are non specific and histopathological study is required for the
diagnosis.
Aim: To study histomorphology of small intestinal lesions and
analyze with respect to age, sex, anatomical site of occurrence
and relative frequency.
Materials and Methods: This study of 124 cases was
undertaken in the Department of Pathology, JSS Medical
College and Hospital, Mysuru, India, between 2009 to 2012. In
addition to H and E, Immunohistochemistry and special stains
were done in required cases.
Results: Total 124 cases of small intestinal lesions including
the periampullary lesions were studied. Of these, 71 cases
(57.25%) were non-neoplastic and 53 cases (42.75%) were
neoplastic. Common age group was 5th-6th decade. A
male preponderance was observed. Most common nonneoplastic lesions were non-specific enteritis (52.11%) and
enteric fever (40%). Amongst neoplastic lesions, total 45
(84.91%) cases were malignant comprising adenocarcinomas
of the periampullary region (49.06%) and carcinoid tumours
(11.32%). Benign lesions were adenomas. Rare cases like
myeloid sarcoma, metastatic adenocarcinoma and metastatic
malignant melanoma were observed.
Conclusion: A greater awareness of various diseases affecting
the small intestine and an understanding of the pathogenesis
on the part of the pathologist is felt necessary for a better
diagnosis. A detailed histopathological study of the small
intestinal specimens should be done in constant correlation
with the clinical and radiological findings for an accurate
diagnosis. |
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| ISSN: | 2277-8551 2455-6882 |