| Summary: | Shuyan Feng,1,* Chi Zhang,1,* Shanshan Chen,2,* Ruonan He,1,* Guanqun Chao,3 Shuo Zhang4 1Zhejiang Chinese Medical University, Hangzhou, 310053, People’s Republic of China; 2The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310006, People’s Republic of China; 3Sir Run Run Shaw Hospital of Zhejiang University, Hangzhou, 310018, People’s Republic of China; 4The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310005, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guanqun Chao; Shuo Zhang, Email chaoguanqun@zju.edu.cn; zhangshuotcm@126.comAbstract: Toll-like receptor 5 (TLR5) is a pattern recognition receptor that specifically recognizes flagellin and consequently plays a crucial role in the control of intestinal homeostasis by activating innate and adaptive immune responses. TLR5 overexpression, on the other hand, might disrupt the intestinal mucosal barrier, which serves as the first line of defense against harmful microbes. The intestine symbiotic bacteria, mucous layer, intestinal epithelial cells (IECs), adherens junctions (such as tight junctions and peripheral membrane proteins), the intestinal mucosal immune system, and cytokines make up the intestinal mucosal barrier. Impaired barrier function has been linked to intestinal illnesses such as inflammatory bowel disease (IBD). IBD is a persistent non-specific inflammatory illness of the digestive system with an unknown cause. It is now thought to be linked to infection, environment, genes, immune system, and the gut microbiota. The significance of immunological dysfunction in IBD has received more attention in recent years. The purpose of this paper is to explore TLR5’s position in the intestinal mucosal barrier and its relevance to IBD.Keywords: toll-like receptor 5, intestinal mucosal barrier, microbes, intestinal immune, inflammatory bowel disease
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