Comparison of Levobupivacaine and Levobupivacaine with Dexmedetomidine for Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries-A Randomised Controlled Trial
Introduction: Brachial plexus blockade at the supraclavicular level delivers an excellent regional anaesthetic technique with unmatched effectiveness for upper limb surgeries. Levobupivacaine, a safer alternative to the commonly used bupivacaine for regional anaesthesia and addition of a2- agon...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2021-03-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://www.jcdr.net/articles/PDF/14590/47344_CE[Ra1]_F(KM)_PF1(AGAK)_PFA(KM)_PB(AG_KM)_GC(SHU_PrG)_PN(KM).pdf |
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| author | Balraj Hariharasudhan Sridhar Savithasre Rajesh S Mane S Sivakumar BT Ari |
| author_facet | Balraj Hariharasudhan Sridhar Savithasre Rajesh S Mane S Sivakumar BT Ari |
| author_sort | Balraj Hariharasudhan |
| collection | DOAJ |
| description | Introduction: Brachial plexus blockade at the supraclavicular
level delivers an excellent regional anaesthetic technique
with unmatched effectiveness for upper limb surgeries.
Levobupivacaine, a safer alternative to the commonly used
bupivacaine for regional anaesthesia and addition of a2-
agonists like dexmedetomidine further improves the quality of
regional anaesthesia.
Aim: To evaluate the efficacy of levobupivacaine in combination
with dexmedetomidine for supraclavicular brachial plexus block.
Materials and Methods: This randomised controlled study
enrolled 50 American Society of Anaesthesiologist (ASA) grade I
and II patients aged between 18-60 years posted for elective
upper limb surgeries. Randomisation was done and the patients
were divided into two groups with 25 each, to receive either 39 mL
of 0.5% levobupivacaine and 100 μgs (1 mL) of dexmedetomidine
in group LD (Levobupivacaine with Dexmedetomidine) and
39 mL of 0.5% levobupivacaine and 1 mL of normal saline in
group LS (Levobupivacaine with Saline). The onset and duration
of sensory and motor blockade along with duration of analgesia
were observed. All Quantitative data were compared and
analysed using student’s unpaired t test while qualitative data
were analysed using Chi-square test. A p-value of less than 0.05
was considered to be statistically significant.
Results: The onset of sensory and motor blockade in group LD
was significantly faster when compared to group LS (p<0.001).
group LD had a longer mean duration of sensory and motor
blockade along with duration of analgesia when compared to
group LS (p<0.001). There was a better hemodynamic stability in
group LD when compared to group LS.
Conclusion: Dexmedetomidine added to levobupivacaine
provides significantly shorter onset times, greatly prolongs the
duration of sensory and motor blockade along with duration of
analgesia without any systemic side effects. |
| first_indexed | 2024-12-21T10:26:11Z |
| format | Article |
| id | doaj.art-aaf4e59e2c2f480682d4cdc0a1dceb3c |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-21T10:26:11Z |
| publishDate | 2021-03-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-aaf4e59e2c2f480682d4cdc0a1dceb3c2022-12-21T19:07:18ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2021-03-01153UC06UC0910.7860/JCDR/2021/47344.14590Comparison of Levobupivacaine and Levobupivacaine with Dexmedetomidine for Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries-A Randomised Controlled TrialBalraj Hariharasudhan0 Sridhar Savithasre1Rajesh S Mane2 S Sivakumar3BT Ari4Assistant Professor, Department of Anaesthesia and Critical Care, Pondicherry Institute of Medical Sciences, Puducherry, India.Assistant Professor, Department of Pharmacology, Pondicherry Institute of Medical Sciences, Puducherry, India.Professor and Head, Department of Anaesthesia and Critical Care, KLE University of Higher Education and Research, Belagavi, Karnataka, India.Associate Professor, Department of Anaesthesia and Critical Care, Pondicherry Institute of Medical Sciences, Puducherry, India.Assistant Professor, Department of Anaesthesia and Critical Care, Pondicherry Institute of Medical Sciences, Puducherry, India.Introduction: Brachial plexus blockade at the supraclavicular level delivers an excellent regional anaesthetic technique with unmatched effectiveness for upper limb surgeries. Levobupivacaine, a safer alternative to the commonly used bupivacaine for regional anaesthesia and addition of a2- agonists like dexmedetomidine further improves the quality of regional anaesthesia. Aim: To evaluate the efficacy of levobupivacaine in combination with dexmedetomidine for supraclavicular brachial plexus block. Materials and Methods: This randomised controlled study enrolled 50 American Society of Anaesthesiologist (ASA) grade I and II patients aged between 18-60 years posted for elective upper limb surgeries. Randomisation was done and the patients were divided into two groups with 25 each, to receive either 39 mL of 0.5% levobupivacaine and 100 μgs (1 mL) of dexmedetomidine in group LD (Levobupivacaine with Dexmedetomidine) and 39 mL of 0.5% levobupivacaine and 1 mL of normal saline in group LS (Levobupivacaine with Saline). The onset and duration of sensory and motor blockade along with duration of analgesia were observed. All Quantitative data were compared and analysed using student’s unpaired t test while qualitative data were analysed using Chi-square test. A p-value of less than 0.05 was considered to be statistically significant. Results: The onset of sensory and motor blockade in group LD was significantly faster when compared to group LS (p<0.001). group LD had a longer mean duration of sensory and motor blockade along with duration of analgesia when compared to group LS (p<0.001). There was a better hemodynamic stability in group LD when compared to group LS. Conclusion: Dexmedetomidine added to levobupivacaine provides significantly shorter onset times, greatly prolongs the duration of sensory and motor blockade along with duration of analgesia without any systemic side effects.https://www.jcdr.net/articles/PDF/14590/47344_CE[Ra1]_F(KM)_PF1(AGAK)_PFA(KM)_PB(AG_KM)_GC(SHU_PrG)_PN(KM).pdfnerve stimulator guidedperipheral nerve blockaderegional anaesthesiaupper limb blockade |
| spellingShingle | Balraj Hariharasudhan Sridhar Savithasre Rajesh S Mane S Sivakumar BT Ari Comparison of Levobupivacaine and Levobupivacaine with Dexmedetomidine for Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries-A Randomised Controlled Trial Journal of Clinical and Diagnostic Research nerve stimulator guided peripheral nerve blockade regional anaesthesia upper limb blockade |
| title | Comparison of Levobupivacaine and Levobupivacaine with Dexmedetomidine for Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries-A Randomised Controlled Trial |
| title_full | Comparison of Levobupivacaine and Levobupivacaine with Dexmedetomidine for Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries-A Randomised Controlled Trial |
| title_fullStr | Comparison of Levobupivacaine and Levobupivacaine with Dexmedetomidine for Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries-A Randomised Controlled Trial |
| title_full_unstemmed | Comparison of Levobupivacaine and Levobupivacaine with Dexmedetomidine for Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries-A Randomised Controlled Trial |
| title_short | Comparison of Levobupivacaine and Levobupivacaine with Dexmedetomidine for Supraclavicular Brachial Plexus Block in Patients Undergoing Upper Limb Surgeries-A Randomised Controlled Trial |
| title_sort | comparison of levobupivacaine and levobupivacaine with dexmedetomidine for supraclavicular brachial plexus block in patients undergoing upper limb surgeries a randomised controlled trial |
| topic | nerve stimulator guided peripheral nerve blockade regional anaesthesia upper limb blockade |
| url | https://www.jcdr.net/articles/PDF/14590/47344_CE[Ra1]_F(KM)_PF1(AGAK)_PFA(KM)_PB(AG_KM)_GC(SHU_PrG)_PN(KM).pdf |
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