Role and Mechanism of Lactylation in Cancer

Role and Mechanism of Lactylation in Cancer

Post translational modifications (PTMs) can change the properties of a protein by covalent addition of functional groups to one or more amino acids, and influence almost all aspects of normal cell biology and pathogenesis. Lactylation is a novel identified PTM, and has been found in both histone and...

Descrizione completa

Dettagli Bibliografici
Autori principali:	Qicheng ZHANG, Limin CAO, Ke XU
Natura:	Articolo
Lingua:	zho
Pubblicazione:	Chinese Anti-Cancer Association; Chinese Antituberculosis Association 2024-06-01
Serie:	Chinese Journal of Lung Cancer
Soggetti:	lactate lactylation cancer
Accesso online:	http://dx.doi.org/10.3779/j.issn.1009-3419.2024.102.20

Documenti analoghi

The role of nonhistone lactylation in disease
di: Hao Yu, et al.
Pubblicazione: (2024-09-01)

The role of lactate and lactylation in ischemic cardiomyopathy: Mechanisms and gene expression
di: Mei Zhang, et al.
Pubblicazione: (2025-03-01)

New insights into the roles of lactylation in cancer
di: Yajun Zhu, et al.
Pubblicazione: (2024-10-01)

The function and mechanism of lactate and lactylation in tumor metabolism and microenvironment
di: Yan Zhang, et al.
Pubblicazione: (2023-09-01)

Ubiquitous protein lactylation in health and diseases
di: Junyong Wang, et al.
Pubblicazione: (2024-02-01)

Lactate and Lactylation in Sepsis: A Comprehensive Review
di: Liu S, et al.
Pubblicazione: (2024-07-01)

Lactate-induced protein lactylation in cancer: functions, biomarkers and immunotherapy strategies
di: Wenjuan Wang, et al.
Pubblicazione: (2025-01-01)

Demethylzeylasteral targets lactate to suppress the tumorigenicity of liver cancer stem cells: It is attributed to histone lactylation?
di: Hang Gong, et al.
Pubblicazione: (2023-08-01)

Demethylzeylasteral targets lactate by inhibiting histone lactylation to suppress the tumorigenicity of liver cancer stem cells
di: Lianhong Pan, et al.
Pubblicazione: (2022-07-01)

The role of lactate-induced protein lactylation in gliomas: implications for preclinical research and the development of new treatments
di: Xiaoying Liu, et al.
Pubblicazione: (2024-06-01)

Lactate metabolism and histone lactylation in the central nervous system disorders: impacts and molecular mechanisms
di: Yao Wang, et al.
Pubblicazione: (2024-11-01)

Potential biomarker for diagnosis and therapy of sepsis: Lactylation
di: ZeXian Sun, et al.
Pubblicazione: (2023-10-01)

Lactate and lysine lactylation of histone regulate transcription in cancer
di: Yunhao Yang, et al.
Pubblicazione: (2024-11-01)

Post-translational protein lactylation modification in health and diseases: a double-edged sword
di: Hang Gong, et al.
Pubblicazione: (2024-01-01)

Lactate promotes myogenesis via activating H3K9 lactylation‐dependent up‐regulation of Neu2 expression
di: Weilong Dai, et al.
Pubblicazione: (2023-12-01)

Lactylation, an emerging hallmark of metabolic reprogramming: Current progress and open challenges
di: Xuelian Liu, et al.
Pubblicazione: (2022-08-01)

Lactate activates CCL18 expression via H3K18 lactylation in macrophages to promote tumorigenesis of ovarian cancer
di: Sun Jinrui, et al.
Pubblicazione: (2024-07-01)

Lactylation, a Novel Metabolic Reprogramming Code: Current Status and Prospects
di: An-Na Chen, et al.
Pubblicazione: (2021-06-01)

Lactate metabolism and lactylation in cardiovascular disease: novel mechanisms and therapeutic targets
di: Han Zhang, et al.
Pubblicazione: (2024-11-01)

Resistance training in humans and mechanical overload in rodents do not elevate muscle protein lactylation
di: Madison L. Mattingly, et al.
Pubblicazione: (2023-09-01)

A review of lactate-lactylation in malignancy: its potential in immunotherapy
di: Jinhui Zha, et al.
Pubblicazione: (2024-05-01)

Interplay between metabolic reprogramming and post-translational modifications: from glycolysis to lactylation
di: Hengwei Wu, et al.
Pubblicazione: (2023-06-01)

Lactylation: The emerging frontier in post-translational modification
di: Zhou Lu, et al.
Pubblicazione: (2024-06-01)

Lactylation modification in cancer: mechanisms, functions, and therapeutic strategies
di: Mengqi Lv, et al.
Pubblicazione: (2025-03-01)

Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia
di: Hao Han, et al.
Pubblicazione: (2023-11-01)

The relationship and clinical significance of lactylation modification in digestive system tumors
di: Gang Wang, et al.
Pubblicazione: (2024-07-01)

Lactate and Lactylation: Dual Regulators of T-Cell-Mediated Tumor Immunity and Immunotherapy
di: Zhi-Nan Hao, et al.
Pubblicazione: (2024-12-01)

Recent advances of lysine lactylation in prokaryotes and eukaryotes
di: Wenjuan Zhao, et al.
Pubblicazione: (2025-01-01)

Protein Lactylation Critically Regulates Energy Metabolism in the Protozoan Parasite Trypanosoma brucei
di: Naiwen Zhang, et al.
Pubblicazione: (2021-10-01)

Lactate Modulates Cellular Metabolism Through Histone Lactylation-Mediated Gene Expression in Non-Small Cell Lung Cancer
di: Jun Jiang, et al.
Pubblicazione: (2021-06-01)

Lactate and lactylation in macrophage metabolic reprogramming: current progress and outstanding issues
di: Bangjun Xu, et al.
Pubblicazione: (2024-05-01)

Hippocampal Lactate-Infusion Enhances Spatial Memory Correlated with Monocarboxylate Transporter 2 and Lactylation
di: Yuhan Wu, et al.
Pubblicazione: (2024-03-01)

Endothelial Cell‐Derived Lactate Triggers Bone Mesenchymal Stem Cell Histone Lactylation to Attenuate Osteoporosis
di: Jinhui Wu, et al.
Pubblicazione: (2023-11-01)

The mechanism of PFK-1 in the occurrence and development of bladder cancer by regulating ZEB1 lactylation
di: Rong Wang, et al.
Pubblicazione: (2024-03-01)

Systematic identification of the lysine lactylation in the protozoan parasite Toxoplasma gondii
di: Wei Zhao, et al.
Pubblicazione: (2022-05-01)

Glycolytic reprogramming governs crystalline silica-induced pyroptosis and inflammation through promoting lactylation modification
di: Xiaojie You, et al.
Pubblicazione: (2024-09-01)

Predictive role of lactylation-related gene signature in the prognosis and immunotherapy response in bladder cancer
di: Guoyuan Liu, et al.
Pubblicazione: (2025-02-01)

The role of lactylation in tumor growth and cancer progression
di: Khulood Al-Malsi, et al.
Pubblicazione: (2025-02-01)

Lactate-induced lactylation in skeletal muscle is associated with insulin resistance in humans
di: Dominic Maschari, et al.
Pubblicazione: (2022-08-01)

Glucose transporter 3 (GLUT3) promotes lactylation modifications by regulating lactate dehydrogenase A (LDHA) in gastric cancer
di: Hao Yang, et al.
Pubblicazione: (2023-12-01)