A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end-stage renal disease risk in IgA nephropathy patients
Background and objective: The association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and end-stage renal disease (ESRD) risk in IgA nephropathy (IgAN) patients is still controversial. A meta-analysis was performed to evaluate the association between ACE I/...
Main Authors: | , , |
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Format: | Article |
Language: | English |
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SAGE Publications
2013-09-01
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Series: | Journal of the Renin-Angiotensin-Aldosterone System |
Online Access: | https://doi.org/10.1177/1470320312459978 |
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author | Tian-Biao Zhou Sheng-Sheng Yin Rong Liang |
author_facet | Tian-Biao Zhou Sheng-Sheng Yin Rong Liang |
author_sort | Tian-Biao Zhou |
collection | DOAJ |
description | Background and objective: The association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and end-stage renal disease (ESRD) risk in IgA nephropathy (IgAN) patients is still controversial. A meta-analysis was performed to evaluate the association between ACE I/D gene polymorphism and ESRD susceptibility in IgAN patients. Method: A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic databases. Results: Thirteen articles were identified for the analysis of the association between ACE I/D gene polymorphism and ESRD risk in IgAN patients. D allele and DD genotype were associated with ESRD susceptibility in IgAN patients for overall populations ( p =0.01 and 0.003, respectively). In Asians, there was a markedly positive association between DD genotype and ESRD susceptibility ( p =0.03). Furthermore, D allele and DD genotype were associated with ESRD susceptibility in Caucasians ( p =0.02 and 0.03, respectively). However, II genotype might not play a protective role against ESRD onset for overall populations, Asians and Caucasians. Conclusion: DD homozygote is a significant genetic molecular marker for the onset of ESRD in IgAN patients. |
first_indexed | 2024-03-07T17:11:02Z |
format | Article |
id | doaj.art-aafb00555176467e92b3039209713577 |
institution | Directory Open Access Journal |
issn | 1470-3203 1752-8976 |
language | English |
last_indexed | 2024-03-07T17:11:02Z |
publishDate | 2013-09-01 |
publisher | SAGE Publications |
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series | Journal of the Renin-Angiotensin-Aldosterone System |
spelling | doaj.art-aafb00555176467e92b30392097135772024-03-03T01:14:31ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762013-09-011410.1177/1470320312459978A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end-stage renal disease risk in IgA nephropathy patientsTian-Biao Zhou0Sheng-Sheng Yin1Rong Liang2Department of Pediatric Nephrology, The First Affiliated Hospital of Guangxi Medical University, ChinaCollege of Management, Guangxi University for Nationalities, ChinaDepartment of Pediatric-Neonatology, Baylor College of Medicine, USABackground and objective: The association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and end-stage renal disease (ESRD) risk in IgA nephropathy (IgAN) patients is still controversial. A meta-analysis was performed to evaluate the association between ACE I/D gene polymorphism and ESRD susceptibility in IgAN patients. Method: A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic databases. Results: Thirteen articles were identified for the analysis of the association between ACE I/D gene polymorphism and ESRD risk in IgAN patients. D allele and DD genotype were associated with ESRD susceptibility in IgAN patients for overall populations ( p =0.01 and 0.003, respectively). In Asians, there was a markedly positive association between DD genotype and ESRD susceptibility ( p =0.03). Furthermore, D allele and DD genotype were associated with ESRD susceptibility in Caucasians ( p =0.02 and 0.03, respectively). However, II genotype might not play a protective role against ESRD onset for overall populations, Asians and Caucasians. Conclusion: DD homozygote is a significant genetic molecular marker for the onset of ESRD in IgAN patients.https://doi.org/10.1177/1470320312459978 |
spellingShingle | Tian-Biao Zhou Sheng-Sheng Yin Rong Liang A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end-stage renal disease risk in IgA nephropathy patients Journal of the Renin-Angiotensin-Aldosterone System |
title | A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end-stage renal disease risk in IgA nephropathy patients |
title_full | A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end-stage renal disease risk in IgA nephropathy patients |
title_fullStr | A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end-stage renal disease risk in IgA nephropathy patients |
title_full_unstemmed | A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end-stage renal disease risk in IgA nephropathy patients |
title_short | A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end-stage renal disease risk in IgA nephropathy patients |
title_sort | meta analysis of the association between angiotensin converting enzyme insertion deletion gene polymorphism and end stage renal disease risk in iga nephropathy patients |
url | https://doi.org/10.1177/1470320312459978 |
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