A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end-stage renal disease risk in IgA nephropathy patients

Background and objective: The association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and end-stage renal disease (ESRD) risk in IgA nephropathy (IgAN) patients is still controversial. A meta-analysis was performed to evaluate the association between ACE I/...

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Main Authors: Tian-Biao Zhou, Sheng-Sheng Yin, Rong Liang
Format: Article
Language:English
Published: SAGE Publications 2013-09-01
Series:Journal of the Renin-Angiotensin-Aldosterone System
Online Access:https://doi.org/10.1177/1470320312459978
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author Tian-Biao Zhou
Sheng-Sheng Yin
Rong Liang
author_facet Tian-Biao Zhou
Sheng-Sheng Yin
Rong Liang
author_sort Tian-Biao Zhou
collection DOAJ
description Background and objective: The association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and end-stage renal disease (ESRD) risk in IgA nephropathy (IgAN) patients is still controversial. A meta-analysis was performed to evaluate the association between ACE I/D gene polymorphism and ESRD susceptibility in IgAN patients. Method: A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic databases. Results: Thirteen articles were identified for the analysis of the association between ACE I/D gene polymorphism and ESRD risk in IgAN patients. D allele and DD genotype were associated with ESRD susceptibility in IgAN patients for overall populations ( p =0.01 and 0.003, respectively). In Asians, there was a markedly positive association between DD genotype and ESRD susceptibility ( p =0.03). Furthermore, D allele and DD genotype were associated with ESRD susceptibility in Caucasians ( p =0.02 and 0.03, respectively). However, II genotype might not play a protective role against ESRD onset for overall populations, Asians and Caucasians. Conclusion: DD homozygote is a significant genetic molecular marker for the onset of ESRD in IgAN patients.
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spelling doaj.art-aafb00555176467e92b30392097135772024-03-03T01:14:31ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762013-09-011410.1177/1470320312459978A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end-stage renal disease risk in IgA nephropathy patientsTian-Biao Zhou0Sheng-Sheng Yin1Rong Liang2Department of Pediatric Nephrology, The First Affiliated Hospital of Guangxi Medical University, ChinaCollege of Management, Guangxi University for Nationalities, ChinaDepartment of Pediatric-Neonatology, Baylor College of Medicine, USABackground and objective: The association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and end-stage renal disease (ESRD) risk in IgA nephropathy (IgAN) patients is still controversial. A meta-analysis was performed to evaluate the association between ACE I/D gene polymorphism and ESRD susceptibility in IgAN patients. Method: A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic databases. Results: Thirteen articles were identified for the analysis of the association between ACE I/D gene polymorphism and ESRD risk in IgAN patients. D allele and DD genotype were associated with ESRD susceptibility in IgAN patients for overall populations ( p =0.01 and 0.003, respectively). In Asians, there was a markedly positive association between DD genotype and ESRD susceptibility ( p =0.03). Furthermore, D allele and DD genotype were associated with ESRD susceptibility in Caucasians ( p =0.02 and 0.03, respectively). However, II genotype might not play a protective role against ESRD onset for overall populations, Asians and Caucasians. Conclusion: DD homozygote is a significant genetic molecular marker for the onset of ESRD in IgAN patients.https://doi.org/10.1177/1470320312459978
spellingShingle Tian-Biao Zhou
Sheng-Sheng Yin
Rong Liang
A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end-stage renal disease risk in IgA nephropathy patients
Journal of the Renin-Angiotensin-Aldosterone System
title A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end-stage renal disease risk in IgA nephropathy patients
title_full A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end-stage renal disease risk in IgA nephropathy patients
title_fullStr A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end-stage renal disease risk in IgA nephropathy patients
title_full_unstemmed A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end-stage renal disease risk in IgA nephropathy patients
title_short A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end-stage renal disease risk in IgA nephropathy patients
title_sort meta analysis of the association between angiotensin converting enzyme insertion deletion gene polymorphism and end stage renal disease risk in iga nephropathy patients
url https://doi.org/10.1177/1470320312459978
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