Do probiotics promote oral health during orthodontic treatment with fixed appliances? A systematic review
Abstract Background Treatment with fixed orthodontic appliances has been associated with significant biofilm accumulation, thus putting patients at a higher risk of oral health deterioration. The use of probiotics has been proposed to be useful in the prevention or treatment of oral pathologies such...
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| Format: | Article |
| Language: | English |
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BMC
2020-04-01
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| Series: | BMC Oral Health |
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| Online Access: | http://link.springer.com/article/10.1186/s12903-020-01109-3 |
| _version_ | 1819057516704694272 |
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| author | Riham Hadj-Hamou Abiola C. Senok Athanasios E. Athanasiou Eleftherios G. Kaklamanos |
| author_facet | Riham Hadj-Hamou Abiola C. Senok Athanasios E. Athanasiou Eleftherios G. Kaklamanos |
| author_sort | Riham Hadj-Hamou |
| collection | DOAJ |
| description | Abstract Background Treatment with fixed orthodontic appliances has been associated with significant biofilm accumulation, thus putting patients at a higher risk of oral health deterioration. The use of probiotics has been proposed to be useful in the prevention or treatment of oral pathologies such as caries and diseases of periodontal tissues. Our aim was to investigate the effects of probiotic use on inflammation of the gingival tissues and the decalcification of the enamel in patients being treated with fixed orthodontic appliances. Methods We searched without restrictions 8 databases and performed hand searching until September 2019. We searched for randomized controlled trials (RCTs) evaluating whether individuals with fixed orthodontic appliances benefit from probiotic treatment in terms of the inflammation of the gingivae and decalcification of the enamel. Following the selection of studies and the extraction of pertinent data, we appraised the risk of bias and the confidence in the observed effects based on established methodologies. Results From the final qualifying studies, three did not show any statistically significant effect on gingival inflammation after probiotic administration of up to 1 month. Similarly, non-significant differences were noted in another study regarding white spot lesions development (mean administration for 17 months). No adverse effects were reported and the level of evidence was considered moderate. Conclusions Supplementation of orthodontic patients with probiotics did not affect the development of inflammation in the gingivae and decalcification in the enamel. Additional RCTs, with longer intervention and follow-up periods, and involving different combinations of probiotic strains are required. Trial registration PROSPERO ( CRD42018118008 ) |
| first_indexed | 2024-12-21T13:40:33Z |
| format | Article |
| id | doaj.art-aafe27dcb6394d81accaf560c6240c12 |
| institution | Directory Open Access Journal |
| issn | 1472-6831 |
| language | English |
| last_indexed | 2024-12-21T13:40:33Z |
| publishDate | 2020-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj.art-aafe27dcb6394d81accaf560c6240c122022-12-21T19:02:01ZengBMCBMC Oral Health1472-68312020-04-012011910.1186/s12903-020-01109-3Do probiotics promote oral health during orthodontic treatment with fixed appliances? A systematic reviewRiham Hadj-Hamou0Abiola C. Senok1Athanasios E. Athanasiou2Eleftherios G. Kaklamanos3Specialist Orthodontist, Dubai, United Arab Emirates; formerly Hamdan Bin Mohammed College of Dental Medicine, Mohammed Bin Rashid University of Medicine and Health SciencesCollege of Medicine, Mohammed Bin Rashid University of Medicine and Health SciencesDepartment of Dentistry, European University CyprusHamdan Bin Mohammed College of Dental Medicine (HBMCDM), Mohammed Bin Rashid University of Medicine and Health SciencesAbstract Background Treatment with fixed orthodontic appliances has been associated with significant biofilm accumulation, thus putting patients at a higher risk of oral health deterioration. The use of probiotics has been proposed to be useful in the prevention or treatment of oral pathologies such as caries and diseases of periodontal tissues. Our aim was to investigate the effects of probiotic use on inflammation of the gingival tissues and the decalcification of the enamel in patients being treated with fixed orthodontic appliances. Methods We searched without restrictions 8 databases and performed hand searching until September 2019. We searched for randomized controlled trials (RCTs) evaluating whether individuals with fixed orthodontic appliances benefit from probiotic treatment in terms of the inflammation of the gingivae and decalcification of the enamel. Following the selection of studies and the extraction of pertinent data, we appraised the risk of bias and the confidence in the observed effects based on established methodologies. Results From the final qualifying studies, three did not show any statistically significant effect on gingival inflammation after probiotic administration of up to 1 month. Similarly, non-significant differences were noted in another study regarding white spot lesions development (mean administration for 17 months). No adverse effects were reported and the level of evidence was considered moderate. Conclusions Supplementation of orthodontic patients with probiotics did not affect the development of inflammation in the gingivae and decalcification in the enamel. Additional RCTs, with longer intervention and follow-up periods, and involving different combinations of probiotic strains are required. Trial registration PROSPERO ( CRD42018118008 )http://link.springer.com/article/10.1186/s12903-020-01109-3ProbioticsGingivitisCariesWhite spot lesionsOral healthOrthodontic treatment |
| spellingShingle | Riham Hadj-Hamou Abiola C. Senok Athanasios E. Athanasiou Eleftherios G. Kaklamanos Do probiotics promote oral health during orthodontic treatment with fixed appliances? A systematic review BMC Oral Health Probiotics Gingivitis Caries White spot lesions Oral health Orthodontic treatment |
| title | Do probiotics promote oral health during orthodontic treatment with fixed appliances? A systematic review |
| title_full | Do probiotics promote oral health during orthodontic treatment with fixed appliances? A systematic review |
| title_fullStr | Do probiotics promote oral health during orthodontic treatment with fixed appliances? A systematic review |
| title_full_unstemmed | Do probiotics promote oral health during orthodontic treatment with fixed appliances? A systematic review |
| title_short | Do probiotics promote oral health during orthodontic treatment with fixed appliances? A systematic review |
| title_sort | do probiotics promote oral health during orthodontic treatment with fixed appliances a systematic review |
| topic | Probiotics Gingivitis Caries White spot lesions Oral health Orthodontic treatment |
| url | http://link.springer.com/article/10.1186/s12903-020-01109-3 |
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