Targeted Therapy for Cystic Fibrosis in Children
A mutation in the CFTR gene causes the malfunctioning of the CFTR protein that is located on the apical membrane of epithelial cells and functions as a chloride channel. The discovery of CFTR modulators is an advance in cystic fibrosis treatment.Objective: To analyze modern Russian and foreign liter...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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Scientific Research Institute, Ochapovsky Regional Clinical Hospital no. 1
2023-11-01
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| Series: | Инновационная медицина Кубани |
| Subjects: | |
| Online Access: | https://www.innovmedkub.ru/jour/article/view/773 |
| _version_ | 1826575592224456704 |
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| author | A. V. Burlutskaya V. Yu. Brisin A. V. Statova O. Yu. Zenkina J. V. Pisotskaya |
| author_facet | A. V. Burlutskaya V. Yu. Brisin A. V. Statova O. Yu. Zenkina J. V. Pisotskaya |
| author_sort | A. V. Burlutskaya |
| collection | DOAJ |
| description | A mutation in the CFTR gene causes the malfunctioning of the CFTR protein that is located on the apical membrane of epithelial cells and functions as a chloride channel. The discovery of CFTR modulators is an advance in cystic fibrosis treatment.Objective: To analyze modern Russian and foreign literature on targeted therapy for cystic fibrosis in children. We also describe the history of cystic fibrosis, evolution in its diagnosis and treatment, and mechanisms behind targeted therapy for cystic fibrosis. |
| first_indexed | 2024-03-07T15:35:04Z |
| format | Article |
| id | doaj.art-aafe4a42e7454c35a491b8f0d2d020f6 |
| institution | Directory Open Access Journal |
| issn | 2541-9897 |
| language | Russian |
| last_indexed | 2025-03-14T13:17:09Z |
| publishDate | 2023-11-01 |
| publisher | Scientific Research Institute, Ochapovsky Regional Clinical Hospital no. 1 |
| record_format | Article |
| series | Инновационная медицина Кубани |
| spelling | doaj.art-aafe4a42e7454c35a491b8f0d2d020f62025-02-28T14:50:43ZrusScientific Research Institute, Ochapovsky Regional Clinical Hospital no. 1Инновационная медицина Кубани2541-98972023-11-010414214710.35401/2541-9897-2023-8-4-142-147420Targeted Therapy for Cystic Fibrosis in ChildrenA. V. Burlutskaya0V. Yu. Brisin1A. V. Statova2O. Yu. Zenkina3J. V. Pisotskaya4Kuban State Medical UniversityChildren’s Regional Clinical HospitalKuban State Medical UniversityKuban State Medical UniversityKuban State Medical UniversityA mutation in the CFTR gene causes the malfunctioning of the CFTR protein that is located on the apical membrane of epithelial cells and functions as a chloride channel. The discovery of CFTR modulators is an advance in cystic fibrosis treatment.Objective: To analyze modern Russian and foreign literature on targeted therapy for cystic fibrosis in children. We also describe the history of cystic fibrosis, evolution in its diagnosis and treatment, and mechanisms behind targeted therapy for cystic fibrosis.https://www.innovmedkub.ru/jour/article/view/773cftr modulatorschildrengenesmutation |
| spellingShingle | A. V. Burlutskaya V. Yu. Brisin A. V. Statova O. Yu. Zenkina J. V. Pisotskaya Targeted Therapy for Cystic Fibrosis in Children Инновационная медицина Кубани cftr modulators children genes mutation |
| title | Targeted Therapy for Cystic Fibrosis in Children |
| title_full | Targeted Therapy for Cystic Fibrosis in Children |
| title_fullStr | Targeted Therapy for Cystic Fibrosis in Children |
| title_full_unstemmed | Targeted Therapy for Cystic Fibrosis in Children |
| title_short | Targeted Therapy for Cystic Fibrosis in Children |
| title_sort | targeted therapy for cystic fibrosis in children |
| topic | cftr modulators children genes mutation |
| url | https://www.innovmedkub.ru/jour/article/view/773 |
| work_keys_str_mv | AT avburlutskaya targetedtherapyforcysticfibrosisinchildren AT vyubrisin targetedtherapyforcysticfibrosisinchildren AT avstatova targetedtherapyforcysticfibrosisinchildren AT oyuzenkina targetedtherapyforcysticfibrosisinchildren AT jvpisotskaya targetedtherapyforcysticfibrosisinchildren |