Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease
Regulatory T cells (Tregs) are key mediators of the immune system. MicroRNAs (miRNAs) are a family of ~22 nucleotide non-coding RNAs that are processed from longer precursors by the RNases Drosha and Dicer. miRNA regulates protein expression posttranscriptionally through mRNA destabilization or tran...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-01-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2018.00057/full |
| _version_ | 1828782725749800960 |
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| author | Keli L. Hippen Michael Loschi Jemma Nicholls Kelli P. A. MacDonald Bruce R. Blazar |
| author_facet | Keli L. Hippen Michael Loschi Jemma Nicholls Kelli P. A. MacDonald Bruce R. Blazar |
| author_sort | Keli L. Hippen |
| collection | DOAJ |
| description | Regulatory T cells (Tregs) are key mediators of the immune system. MicroRNAs (miRNAs) are a family of ~22 nucleotide non-coding RNAs that are processed from longer precursors by the RNases Drosha and Dicer. miRNA regulates protein expression posttranscriptionally through mRNA destabilization or translational silencing. A critical role for miRNA in Treg function was initially discovered when both Dicer and Drosha knockout (KO) mice were found to develop a fatal autoimmune disease phenotypically similar to Foxp3 KO mice. |
| first_indexed | 2024-12-11T17:52:52Z |
| format | Article |
| id | doaj.art-aaffc48bb9644c21a7c85844da35dd9a |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T17:52:52Z |
| publishDate | 2018-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-aaffc48bb9644c21a7c85844da35dd9a2022-12-22T00:56:09ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-01-01910.3389/fimmu.2018.00057326381Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host DiseaseKeli L. Hippen0Michael Loschi1Jemma Nicholls2Kelli P. A. MacDonald3Bruce R. Blazar4Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota Cancer Center, Minneapolis, MN, United StatesDepartment of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota Cancer Center, Minneapolis, MN, United StatesDepartment of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota Cancer Center, Minneapolis, MN, United StatesThe Antigen Presentation and Immunoregulation Laboratory and Bone Marrow Transplantation Laboratory, QIMR Berghofer Medical Research Institute, University of Minnesota Cancer Center, Brisbane, QLD, AustraliaDepartment of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota Cancer Center, Minneapolis, MN, United StatesRegulatory T cells (Tregs) are key mediators of the immune system. MicroRNAs (miRNAs) are a family of ~22 nucleotide non-coding RNAs that are processed from longer precursors by the RNases Drosha and Dicer. miRNA regulates protein expression posttranscriptionally through mRNA destabilization or translational silencing. A critical role for miRNA in Treg function was initially discovered when both Dicer and Drosha knockout (KO) mice were found to develop a fatal autoimmune disease phenotypically similar to Foxp3 KO mice.http://journal.frontiersin.org/article/10.3389/fimmu.2018.00057/fullregulatory T celltTregiTregmicroRNAgraft-versus-host disease |
| spellingShingle | Keli L. Hippen Michael Loschi Jemma Nicholls Kelli P. A. MacDonald Bruce R. Blazar Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease Frontiers in Immunology regulatory T cell tTreg iTreg microRNA graft-versus-host disease |
| title | Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease |
| title_full | Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease |
| title_fullStr | Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease |
| title_full_unstemmed | Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease |
| title_short | Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease |
| title_sort | effects of microrna on regulatory t cells and implications for adoptive cellular therapy to ameliorate graft versus host disease |
| topic | regulatory T cell tTreg iTreg microRNA graft-versus-host disease |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2018.00057/full |
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