Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease

Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease

Regulatory T cells (Tregs) are key mediators of the immune system. MicroRNAs (miRNAs) are a family of ~22 nucleotide non-coding RNAs that are processed from longer precursors by the RNases Drosha and Dicer. miRNA regulates protein expression posttranscriptionally through mRNA destabilization or tran...

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Bibliographic Details
Main Authors: Keli L. Hippen, Michael Loschi, Jemma Nicholls, Kelli P. A. MacDonald, Bruce R. Blazar
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
regulatory T cell
tTreg
iTreg
microRNA
graft-versus-host disease
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00057/full

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