Detection of prostate cancer using prostate imaging reporting and data system score and prostate-specific antigen density in biopsy-naive and prior biopsy-negative patients
Background: Few studies report on indications for prostate biopsy using Prostate Imaging–Reporting and Data System (PI-RADS) score and prostate-specific antigen density (PSAD). No study to date has included biopsy-naïve and prior biopsy-negative patients. Therefore, we evaluated the predictive value...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-09-01
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| Series: | Prostate International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2287888220300258 |
| _version_ | 1827836407083696128 |
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| author | Hyunsoo Ryoo Min Yong Kang Hyun Hwan Sung Byong Chang Jeong Seong Il Seo Seong Soo Jeon Hyun Moo Lee Hwang Gyun Jeon |
| author_facet | Hyunsoo Ryoo Min Yong Kang Hyun Hwan Sung Byong Chang Jeong Seong Il Seo Seong Soo Jeon Hyun Moo Lee Hwang Gyun Jeon |
| author_sort | Hyunsoo Ryoo |
| collection | DOAJ |
| description | Background: Few studies report on indications for prostate biopsy using Prostate Imaging–Reporting and Data System (PI-RADS) score and prostate-specific antigen density (PSAD). No study to date has included biopsy-naïve and prior biopsy-negative patients. Therefore, we evaluated the predictive values of the PI-RADS, version 2 (v2) score combined with PSAD to decrease unnecessary biopsies in biopsy-naïve and prior biopsy-negative patients. Materials and methods: A total of 1,098 patients who underwent multiparametric magnetic resonance imaging at our hospital before a prostate biopsy and who underwent their second prostate biopsy with an initial benign negative prostatic biopsy were included. We found factors associated with clinically significant prostate cancer (csPca). We assessed negative predictive values by stratifying biopsy outcomes by prior biopsy history and PI-RADS score combined with PSAD. Results: The median age was 65 years (interquartile range: 59-70), and the median PSA was 5.1 ng/mL (interquartile range: 3.8-7.1). Multivariate logistic regression analysis revealed that age, prostate volume, PSAD, and PI-RADS score were independent predictors of csPca. In a biopsy-naïve group, 4% with PI-RADS score 1 or 2 had csPca; in a prior biopsy-negative group, 3% with PI-RADS score 1 or 2 had csPca. The csPca detection rate was 2.0% for PSA density <0.15 ng/mL/mL and 4.0% for PSA density 0.15-0.3 ng/mL/mL among patients with PI-RADS score 3 in a biopsy-naïve group. The csPca detection rate was 1.8% for PSA density <0.15 ng/mL/mL and 0.15-0.3 ng/mL/mL among patients with PI-RADS score 3 in a prior biopsy-negative group. Conclusion: Patients with PI-RADS v2 score ≤2, regardless of PSA density, may avoid unnecessary biopsy. Patients with PI-RADS score 3 may avoid unnecessary biopsy through PSA density results. |
| first_indexed | 2024-03-12T06:26:16Z |
| format | Article |
| id | doaj.art-ab0007f5a0154d619b002646c2c641a1 |
| institution | Directory Open Access Journal |
| issn | 2287-8882 |
| language | English |
| last_indexed | 2024-03-12T06:26:16Z |
| publishDate | 2020-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Prostate International |
| spelling | doaj.art-ab0007f5a0154d619b002646c2c641a12023-09-03T01:53:57ZengElsevierProstate International2287-88822020-09-0183125129Detection of prostate cancer using prostate imaging reporting and data system score and prostate-specific antigen density in biopsy-naive and prior biopsy-negative patientsHyunsoo Ryoo0Min Yong Kang1Hyun Hwan Sung2Byong Chang Jeong3Seong Il Seo4Seong Soo Jeon5Hyun Moo Lee6Hwang Gyun Jeon7Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaCorresponding author. Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Korea.; Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaBackground: Few studies report on indications for prostate biopsy using Prostate Imaging–Reporting and Data System (PI-RADS) score and prostate-specific antigen density (PSAD). No study to date has included biopsy-naïve and prior biopsy-negative patients. Therefore, we evaluated the predictive values of the PI-RADS, version 2 (v2) score combined with PSAD to decrease unnecessary biopsies in biopsy-naïve and prior biopsy-negative patients. Materials and methods: A total of 1,098 patients who underwent multiparametric magnetic resonance imaging at our hospital before a prostate biopsy and who underwent their second prostate biopsy with an initial benign negative prostatic biopsy were included. We found factors associated with clinically significant prostate cancer (csPca). We assessed negative predictive values by stratifying biopsy outcomes by prior biopsy history and PI-RADS score combined with PSAD. Results: The median age was 65 years (interquartile range: 59-70), and the median PSA was 5.1 ng/mL (interquartile range: 3.8-7.1). Multivariate logistic regression analysis revealed that age, prostate volume, PSAD, and PI-RADS score were independent predictors of csPca. In a biopsy-naïve group, 4% with PI-RADS score 1 or 2 had csPca; in a prior biopsy-negative group, 3% with PI-RADS score 1 or 2 had csPca. The csPca detection rate was 2.0% for PSA density <0.15 ng/mL/mL and 4.0% for PSA density 0.15-0.3 ng/mL/mL among patients with PI-RADS score 3 in a biopsy-naïve group. The csPca detection rate was 1.8% for PSA density <0.15 ng/mL/mL and 0.15-0.3 ng/mL/mL among patients with PI-RADS score 3 in a prior biopsy-negative group. Conclusion: Patients with PI-RADS v2 score ≤2, regardless of PSA density, may avoid unnecessary biopsy. Patients with PI-RADS score 3 may avoid unnecessary biopsy through PSA density results.http://www.sciencedirect.com/science/article/pii/S2287888220300258Biopsy-naive patientsProstate Imaging Reporting and Data System (PI-RADS) scoreProstate-specific antigen density (PSAD)Prior biopsy-negative patients |
| spellingShingle | Hyunsoo Ryoo Min Yong Kang Hyun Hwan Sung Byong Chang Jeong Seong Il Seo Seong Soo Jeon Hyun Moo Lee Hwang Gyun Jeon Detection of prostate cancer using prostate imaging reporting and data system score and prostate-specific antigen density in biopsy-naive and prior biopsy-negative patients Prostate International Biopsy-naive patients Prostate Imaging Reporting and Data System (PI-RADS) score Prostate-specific antigen density (PSAD) Prior biopsy-negative patients |
| title | Detection of prostate cancer using prostate imaging reporting and data system score and prostate-specific antigen density in biopsy-naive and prior biopsy-negative patients |
| title_full | Detection of prostate cancer using prostate imaging reporting and data system score and prostate-specific antigen density in biopsy-naive and prior biopsy-negative patients |
| title_fullStr | Detection of prostate cancer using prostate imaging reporting and data system score and prostate-specific antigen density in biopsy-naive and prior biopsy-negative patients |
| title_full_unstemmed | Detection of prostate cancer using prostate imaging reporting and data system score and prostate-specific antigen density in biopsy-naive and prior biopsy-negative patients |
| title_short | Detection of prostate cancer using prostate imaging reporting and data system score and prostate-specific antigen density in biopsy-naive and prior biopsy-negative patients |
| title_sort | detection of prostate cancer using prostate imaging reporting and data system score and prostate specific antigen density in biopsy naive and prior biopsy negative patients |
| topic | Biopsy-naive patients Prostate Imaging Reporting and Data System (PI-RADS) score Prostate-specific antigen density (PSAD) Prior biopsy-negative patients |
| url | http://www.sciencedirect.com/science/article/pii/S2287888220300258 |
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