Mitochondrial Neurodegeneration: Lessons from <i>Drosophila melanogaster</i> Models
The fruit fly—i.e., <i>Drosophila melanogaster</i>—has proven to be a very useful model for the understanding of basic physiological processes, such as development or ageing. The availability of straightforward genetic tools that can be used to produce engineered individuals makes this m...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/2/378 |
| _version_ | 1797622082999156736 |
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| author | Michele Brischigliaro Erika Fernandez-Vizarra Carlo Viscomi |
| author_facet | Michele Brischigliaro Erika Fernandez-Vizarra Carlo Viscomi |
| author_sort | Michele Brischigliaro |
| collection | DOAJ |
| description | The fruit fly—i.e., <i>Drosophila melanogaster</i>—has proven to be a very useful model for the understanding of basic physiological processes, such as development or ageing. The availability of straightforward genetic tools that can be used to produce engineered individuals makes this model extremely interesting for the understanding of the mechanisms underlying genetic diseases in physiological models. Mitochondrial diseases are a group of yet-incurable genetic disorders characterized by the malfunction of the oxidative phosphorylation system (OXPHOS), which is the highly conserved energy transformation system present in mitochondria. The generation of <i>D. melanogaster</i> models of mitochondrial disease started relatively recently but has already provided relevant information about the molecular mechanisms and pathological consequences of mitochondrial dysfunction. Here, we provide an overview of such models and highlight the relevance of <i>D. melanogaster</i> as a model to study mitochondrial disorders. |
| first_indexed | 2024-03-11T09:06:11Z |
| format | Article |
| id | doaj.art-ab017d7e81654afba8decb80271f401e |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T09:06:11Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-ab017d7e81654afba8decb80271f401e2023-11-16T19:24:22ZengMDPI AGBiomolecules2218-273X2023-02-0113237810.3390/biom13020378Mitochondrial Neurodegeneration: Lessons from <i>Drosophila melanogaster</i> ModelsMichele Brischigliaro0Erika Fernandez-Vizarra1Carlo Viscomi2Department of Biomedical Sciences, University of Padova, 35131 Padova, ItalyDepartment of Biomedical Sciences, University of Padova, 35131 Padova, ItalyDepartment of Biomedical Sciences, University of Padova, 35131 Padova, ItalyThe fruit fly—i.e., <i>Drosophila melanogaster</i>—has proven to be a very useful model for the understanding of basic physiological processes, such as development or ageing. The availability of straightforward genetic tools that can be used to produce engineered individuals makes this model extremely interesting for the understanding of the mechanisms underlying genetic diseases in physiological models. Mitochondrial diseases are a group of yet-incurable genetic disorders characterized by the malfunction of the oxidative phosphorylation system (OXPHOS), which is the highly conserved energy transformation system present in mitochondria. The generation of <i>D. melanogaster</i> models of mitochondrial disease started relatively recently but has already provided relevant information about the molecular mechanisms and pathological consequences of mitochondrial dysfunction. Here, we provide an overview of such models and highlight the relevance of <i>D. melanogaster</i> as a model to study mitochondrial disorders.https://www.mdpi.com/2218-273X/13/2/378mitochondrial diseaseneurodegenerationOXPHOS<i>Drosophila melanogaster</i> |
| spellingShingle | Michele Brischigliaro Erika Fernandez-Vizarra Carlo Viscomi Mitochondrial Neurodegeneration: Lessons from <i>Drosophila melanogaster</i> Models Biomolecules mitochondrial disease neurodegeneration OXPHOS <i>Drosophila melanogaster</i> |
| title | Mitochondrial Neurodegeneration: Lessons from <i>Drosophila melanogaster</i> Models |
| title_full | Mitochondrial Neurodegeneration: Lessons from <i>Drosophila melanogaster</i> Models |
| title_fullStr | Mitochondrial Neurodegeneration: Lessons from <i>Drosophila melanogaster</i> Models |
| title_full_unstemmed | Mitochondrial Neurodegeneration: Lessons from <i>Drosophila melanogaster</i> Models |
| title_short | Mitochondrial Neurodegeneration: Lessons from <i>Drosophila melanogaster</i> Models |
| title_sort | mitochondrial neurodegeneration lessons from i drosophila melanogaster i models |
| topic | mitochondrial disease neurodegeneration OXPHOS <i>Drosophila melanogaster</i> |
| url | https://www.mdpi.com/2218-273X/13/2/378 |
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