| Summary: | The search for alternative therapies to insulin for the treatment of gestational diabetes goes back to studies from the decade of 1970 and 1980. The oral hypoglycemic agents have emerged as an effective alternative for metabolic control of gestational diabetes; these drugs have historically been rejected by the medical community on the basis of studies with serious methodological flaws. Metformin is a useful and safe alternative for its control, to reduce costs and improve the margin of safety that involves the use of insulin. There is sufficient information that supports that glyburide is safe during pregnancy. Many of the fears for the use of oral hypoglycemic agents have been clarified today. Up to now it has not been reported in pregnant the use of other oral hypoglycemic agents and, therefore, they must not be used.
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