ECHOPAEDIA: Echography in Paediatric Patients in the Age of Coronavirus Disease 2019: Utility of Lung Ultrasound and Chest X-Ray in Diagnosis of Community-Acquired Pneumonia and Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia
BackgroundIn recent years, lung ultrasound (LUS) has spread to emergency departments and clinical practise gaining great support, especially in time of pandemic, but only a few studies have been done on children. The aim of the present study is to compare the diagnostic accuracy of LUS (using Soldat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.813874/full |
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| author | Ivan Fiorito Giulia Gori Tiziano Perrone Amelia Mascolo Silvia Caimmi Ilaria Palumbo Annalisa De Silvestri Mariangela Delliponti Antonio Di Sabatino Gian Luigi Marseglia |
| author_facet | Ivan Fiorito Giulia Gori Tiziano Perrone Amelia Mascolo Silvia Caimmi Ilaria Palumbo Annalisa De Silvestri Mariangela Delliponti Antonio Di Sabatino Gian Luigi Marseglia |
| author_sort | Ivan Fiorito |
| collection | DOAJ |
| description | BackgroundIn recent years, lung ultrasound (LUS) has spread to emergency departments and clinical practise gaining great support, especially in time of pandemic, but only a few studies have been done on children. The aim of the present study is to compare the diagnostic accuracy of LUS (using Soldati LUS score) and that of chest X-ray (CXR) in CAP and COVID-19 pneumonia in paediatric patients. Secondary objective of the study is to examine the association between LUS score and disease severity. Finally, we describe the local epidemiology of paediatric CAP during the study period in the era of COVID-19 by comparing it with the previous 2 years.MethodsThis is an observational retrospective single-centre study carried out on patients aged 18 or younger and over the month of age admitted to the Paediatric Unit of our Foundation for suspected community-acquired pneumonia or SARS-CoV-2 pneumonia during the third pandemic wave of COVID-19. Quantitative variables were elaborated with Shapiro–Wilks test or median and interquartile range (IQR). Student's t-test was used for independent data. Association between quantitative data was evaluated with Pearson correlation. ROC curve analysis was used to calculate best cut-off of LUS score in paediatric patients. Area under the ROC curve (AUC), sensibility, and specificity are also reported with 95% confidence interval (CI).ResultsThe diagnostic accuracy of the LUS score in pneumonia, the area underlying the ROC curve (AUC) was 0.67 (95% CI: 0.27–1) thus showing a discrete discriminatory power, with a sensitivity of 89.66% and specificity 50% setting a LUS score greater than or equal to 1 as the best cut-off. Nine patients required oxygen support and a significant statistical correlation (p = 0.0033) emerged between LUS score and oxygen therapy. The mean LUS score in patients requiring oxygen therapy was 12. RCP was positively correlated to the patient's LUS score (p = 0.0024).ConclusionsOur study has shown that LUS is a valid alternative to CXR. Our results show how LUS score can be applied effectively for the diagnosis and stratification of paediatric pneumonia. |
| first_indexed | 2024-12-20T19:14:41Z |
| format | Article |
| id | doaj.art-ab04e42ddeaf48c89ec472069d01f2a6 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-20T19:14:41Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-ab04e42ddeaf48c89ec472069d01f2a62022-12-21T19:29:09ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-02-011010.3389/fped.2022.813874813874ECHOPAEDIA: Echography in Paediatric Patients in the Age of Coronavirus Disease 2019: Utility of Lung Ultrasound and Chest X-Ray in Diagnosis of Community-Acquired Pneumonia and Severe Acute Respiratory Syndrome Coronavirus 2 PneumoniaIvan Fiorito0Giulia Gori1Tiziano Perrone2Amelia Mascolo3Silvia Caimmi4Ilaria Palumbo5Annalisa De Silvestri6Mariangela Delliponti7Antonio Di Sabatino8Gian Luigi Marseglia9Department of Pediatrics, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, ItalyDepartment of Internal Medicine, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, ItalyEmergency Unit, Humanitas Gavazzeni, Bergamo, ItalyDepartment of Pediatrics, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, ItalyDepartment of Pediatrics, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, ItalyDepartment of Internal Medicine, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, ItalyUnit of Clinical Epidemiology and Biometrics, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, ItalyDepartment of Internal Medicine, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, ItalyDepartment of Internal Medicine, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, ItalyDepartment of Pediatrics, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, ItalyBackgroundIn recent years, lung ultrasound (LUS) has spread to emergency departments and clinical practise gaining great support, especially in time of pandemic, but only a few studies have been done on children. The aim of the present study is to compare the diagnostic accuracy of LUS (using Soldati LUS score) and that of chest X-ray (CXR) in CAP and COVID-19 pneumonia in paediatric patients. Secondary objective of the study is to examine the association between LUS score and disease severity. Finally, we describe the local epidemiology of paediatric CAP during the study period in the era of COVID-19 by comparing it with the previous 2 years.MethodsThis is an observational retrospective single-centre study carried out on patients aged 18 or younger and over the month of age admitted to the Paediatric Unit of our Foundation for suspected community-acquired pneumonia or SARS-CoV-2 pneumonia during the third pandemic wave of COVID-19. Quantitative variables were elaborated with Shapiro–Wilks test or median and interquartile range (IQR). Student's t-test was used for independent data. Association between quantitative data was evaluated with Pearson correlation. ROC curve analysis was used to calculate best cut-off of LUS score in paediatric patients. Area under the ROC curve (AUC), sensibility, and specificity are also reported with 95% confidence interval (CI).ResultsThe diagnostic accuracy of the LUS score in pneumonia, the area underlying the ROC curve (AUC) was 0.67 (95% CI: 0.27–1) thus showing a discrete discriminatory power, with a sensitivity of 89.66% and specificity 50% setting a LUS score greater than or equal to 1 as the best cut-off. Nine patients required oxygen support and a significant statistical correlation (p = 0.0033) emerged between LUS score and oxygen therapy. The mean LUS score in patients requiring oxygen therapy was 12. RCP was positively correlated to the patient's LUS score (p = 0.0024).ConclusionsOur study has shown that LUS is a valid alternative to CXR. Our results show how LUS score can be applied effectively for the diagnosis and stratification of paediatric pneumonia.https://www.frontiersin.org/articles/10.3389/fped.2022.813874/fulllung ultrasoundpneumoniachildrenLUS scoreSARS-CoV-2 |
| spellingShingle | Ivan Fiorito Giulia Gori Tiziano Perrone Amelia Mascolo Silvia Caimmi Ilaria Palumbo Annalisa De Silvestri Mariangela Delliponti Antonio Di Sabatino Gian Luigi Marseglia ECHOPAEDIA: Echography in Paediatric Patients in the Age of Coronavirus Disease 2019: Utility of Lung Ultrasound and Chest X-Ray in Diagnosis of Community-Acquired Pneumonia and Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia Frontiers in Pediatrics lung ultrasound pneumonia children LUS score SARS-CoV-2 |
| title | ECHOPAEDIA: Echography in Paediatric Patients in the Age of Coronavirus Disease 2019: Utility of Lung Ultrasound and Chest X-Ray in Diagnosis of Community-Acquired Pneumonia and Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia |
| title_full | ECHOPAEDIA: Echography in Paediatric Patients in the Age of Coronavirus Disease 2019: Utility of Lung Ultrasound and Chest X-Ray in Diagnosis of Community-Acquired Pneumonia and Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia |
| title_fullStr | ECHOPAEDIA: Echography in Paediatric Patients in the Age of Coronavirus Disease 2019: Utility of Lung Ultrasound and Chest X-Ray in Diagnosis of Community-Acquired Pneumonia and Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia |
| title_full_unstemmed | ECHOPAEDIA: Echography in Paediatric Patients in the Age of Coronavirus Disease 2019: Utility of Lung Ultrasound and Chest X-Ray in Diagnosis of Community-Acquired Pneumonia and Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia |
| title_short | ECHOPAEDIA: Echography in Paediatric Patients in the Age of Coronavirus Disease 2019: Utility of Lung Ultrasound and Chest X-Ray in Diagnosis of Community-Acquired Pneumonia and Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia |
| title_sort | echopaedia echography in paediatric patients in the age of coronavirus disease 2019 utility of lung ultrasound and chest x ray in diagnosis of community acquired pneumonia and severe acute respiratory syndrome coronavirus 2 pneumonia |
| topic | lung ultrasound pneumonia children LUS score SARS-CoV-2 |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.813874/full |
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