The frequency and validity of self-reported diagnosis of Parkinson's Disease in the UK elderly: MRC CFAS cohort
<p>Abstract</p> <p>Background</p> <p>Estimates of the incidence and prevalence of chronic diseases can be made using established cohort studies but these estimates may have lower reliability if based purely on self-reported diagnosis.</p> <p>Methods</p>...
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BMC
2006-08-01
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| Series: | BMC Neurology |
| Online Access: | http://www.biomedcentral.com/1471-2377/6/29 |
| _version_ | 1811259871811600384 |
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| author | Ishihara Lianna Matthews Fiona E Foltynie Thomas Brayne Carol |
| author_facet | Ishihara Lianna Matthews Fiona E Foltynie Thomas Brayne Carol |
| author_sort | Ishihara Lianna |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Estimates of the incidence and prevalence of chronic diseases can be made using established cohort studies but these estimates may have lower reliability if based purely on self-reported diagnosis.</p> <p>Methods</p> <p>The MRC Cognitive Function & Ageing Study (MRC CFAS) has collected longitudinal data from a population-based random sample of 13004 individuals over the age of 65 years from 5 centres within the UK. Participants were asked at baseline and after a two-year follow-up whether they had received a diagnosis of Parkinson's disease. Our aim was to make estimates of the incidence and prevalence of PD using self-reporting, and then investigate the validity of self-reported diagnosis using other data sources where available, namely death certification and neuropathological examination.</p> <p>Results</p> <p>The self-reported prevalence of Parkinson's disease (PD) amongst these individuals increases with age from 0.7% (95%CI 0.5–0.9) for 65–75, 1.4% (95%CI 1.0–1.7) for 75–85, and 1.6% (95%CI 1.0–2.3) for 85+ age groups respectively. The overall incidence of self reported PD in this cohort was 200/100,000 per year (95%CI 144–278). Only 40% of the deceased individuals reporting prevalent PD and 35% of those reporting incident PD had diagnoses of PD recorded on their death certificates. Neuropathological examination of individuals reporting PD also showed typical PD changes in only 40%, with the remainder showing basal ganglia pathologies causing parkinsonism rather than true PD pathology.</p> <p>Conclusion</p> <p>Self-reporting of PD status may be used as a screening tool to identify patients for epidemiological study, but inevitably identifies a heterogeneous group of movement disorders patients. Within this group, age, male sex, a family history of PD and reduced cigarette smoking appear to act as independent risk factors for self-reported PD.</p> |
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| format | Article |
| id | doaj.art-ab06ad0b4f8a465b8b267a9a0bb78a24 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-04-12T18:38:08Z |
| publishDate | 2006-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-ab06ad0b4f8a465b8b267a9a0bb78a242022-12-22T03:20:53ZengBMCBMC Neurology1471-23772006-08-01612910.1186/1471-2377-6-29The frequency and validity of self-reported diagnosis of Parkinson's Disease in the UK elderly: MRC CFAS cohortIshihara LiannaMatthews Fiona EFoltynie ThomasBrayne Carol<p>Abstract</p> <p>Background</p> <p>Estimates of the incidence and prevalence of chronic diseases can be made using established cohort studies but these estimates may have lower reliability if based purely on self-reported diagnosis.</p> <p>Methods</p> <p>The MRC Cognitive Function & Ageing Study (MRC CFAS) has collected longitudinal data from a population-based random sample of 13004 individuals over the age of 65 years from 5 centres within the UK. Participants were asked at baseline and after a two-year follow-up whether they had received a diagnosis of Parkinson's disease. Our aim was to make estimates of the incidence and prevalence of PD using self-reporting, and then investigate the validity of self-reported diagnosis using other data sources where available, namely death certification and neuropathological examination.</p> <p>Results</p> <p>The self-reported prevalence of Parkinson's disease (PD) amongst these individuals increases with age from 0.7% (95%CI 0.5–0.9) for 65–75, 1.4% (95%CI 1.0–1.7) for 75–85, and 1.6% (95%CI 1.0–2.3) for 85+ age groups respectively. The overall incidence of self reported PD in this cohort was 200/100,000 per year (95%CI 144–278). Only 40% of the deceased individuals reporting prevalent PD and 35% of those reporting incident PD had diagnoses of PD recorded on their death certificates. Neuropathological examination of individuals reporting PD also showed typical PD changes in only 40%, with the remainder showing basal ganglia pathologies causing parkinsonism rather than true PD pathology.</p> <p>Conclusion</p> <p>Self-reporting of PD status may be used as a screening tool to identify patients for epidemiological study, but inevitably identifies a heterogeneous group of movement disorders patients. Within this group, age, male sex, a family history of PD and reduced cigarette smoking appear to act as independent risk factors for self-reported PD.</p>http://www.biomedcentral.com/1471-2377/6/29 |
| spellingShingle | Ishihara Lianna Matthews Fiona E Foltynie Thomas Brayne Carol The frequency and validity of self-reported diagnosis of Parkinson's Disease in the UK elderly: MRC CFAS cohort BMC Neurology |
| title | The frequency and validity of self-reported diagnosis of Parkinson's Disease in the UK elderly: MRC CFAS cohort |
| title_full | The frequency and validity of self-reported diagnosis of Parkinson's Disease in the UK elderly: MRC CFAS cohort |
| title_fullStr | The frequency and validity of self-reported diagnosis of Parkinson's Disease in the UK elderly: MRC CFAS cohort |
| title_full_unstemmed | The frequency and validity of self-reported diagnosis of Parkinson's Disease in the UK elderly: MRC CFAS cohort |
| title_short | The frequency and validity of self-reported diagnosis of Parkinson's Disease in the UK elderly: MRC CFAS cohort |
| title_sort | frequency and validity of self reported diagnosis of parkinson s disease in the uk elderly mrc cfas cohort |
| url | http://www.biomedcentral.com/1471-2377/6/29 |
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