Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child.

Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child.

BACKGROUND:Countries worldwide recommend women planning pregnancy to use daily 400 microg of synthetic folic acid in the periconceptional period to prevent birth defects in children. The underlying mechanisms of this preventive effect are not clear, however, epigenetic modulation of growth processes...

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Bibliographic Details
Main Authors: Régine P Steegers-Theunissen, Sylvia A Obermann-Borst, Dennis Kremer, Jan Lindemans, Cissy Siebel, Eric A Steegers, P Eline Slagboom, Bastiaan T Heijmans
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-11-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2773848?pdf=render

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