Novel Small Molecules Capable of Blocking mtRAS-Signaling Pathway

Novel Small Molecules Capable of Blocking mtRAS-Signaling Pathway

RAS mutants are involved in approximately 30% of all human cancers and have been regarded as undruggable targets owing to relatively smooth protein surface and obscure binding pockets. In our previous study, we have demonstrated that GNF-7, a multi-targeted kinase inhibitor, possesses potent anti-pr...

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Bibliographic Details
Main Authors: Namkyoung Kim, Injae Shin, Younghoon Kim, Eunhye Jeon, Jiwon Lee, Chaeyoung Lee, Yunju Nam, Sumin Lee, Eunhye Ju, Chan Kim, Woolim Son, SeongShick Ryu, Minjoo Ko, Taebo Sim
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Oncology
Subjects:
RAS signaling pathway
cancers with mtRAS
mutated RAS
RAS signaling blocker
multi-targeted kinase inhibitor
GNF-7
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.768022/full

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