Pathogenic Microglia Orchestrate Neurotoxic Properties of Eomes-Expressing Helper T Cells

Pathogenic Microglia Orchestrate Neurotoxic Properties of Eomes-Expressing Helper T Cells

In addition to disease-associated microglia (DAM), microglia with MHC-II and/or IFN-I signatures may form additional pathogenic subsets that are relevant to neurodegeneration. However, the significance of such MHC-II and IFN-I signatures remains elusive. We demonstrate here that these microglial sub...

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Bibliographic Details
Main Authors: Chenyang Zhang, Ben Raveney, Fumio Takahashi, Tzu-wen Yeh, Hirohiko Hohjoh, Takashi Yamamura, Shinji Oki
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Cells
Subjects:
microglia
neurodegeneration
progressive multiple sclerosis
Online Access:https://www.mdpi.com/2073-4409/12/6/868

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