Computational Insights into the Potential of Withaferin-A, Withanone and Caffeic Acid Phenethyl Ester for Treatment of Aberrant-EGFR Driven Lung Cancers

Computational Insights into the Potential of Withaferin-A, Withanone and Caffeic Acid Phenethyl Ester for Treatment of Aberrant-EGFR Driven Lung Cancers

The anticancer activities of Withaferin-A (Wi-A) and Withanone (Wi-N) from Ashwagandha and Caffeic Acid Phenethyl Ester (CAPE) from honeybee propolis have been well documented. Here, we examined the binding potential of these natural compounds to inhibit the constitutive phosphorylation of epidermal...

Bibliografski detalji
Glavni autori:	Vidhi Malik, Vipul Kumar, Sunil C. Kaul, Renu Wadhwa, Durai Sundar
Format:	Članak
Jezik:	English
Izdano:	MDPI AG 2021-01-01
Serija:	Biomolecules
Teme:	EGFR exon 20 insertion mutations Withaferin A Withanone Caffeic Acid Phenethyl Ester ATP competitive inhibitors
Online pristup:	https://www.mdpi.com/2218-273X/11/2/160

Slični predmeti

Potential of Withaferin-A, Withanone and Caffeic Acid Phenethyl ester as ATP-competitive inhibitors of BRAF: A bioinformatics study
od: Vidhi Malik, i dr.
Izdano: (2021-01-01)

Computational Identification of BCR-ABL Oncogenic Signaling as a Candidate Target of Withaferin A and Withanone
od: Vidhi Malik, i dr.
Izdano: (2022-01-01)

Phosphatidylserine Exposed Lipid Bilayer Models for Understanding Cancer Cell Selectivity of Natural Compounds: A Molecular Dynamics Simulation Study
od: Navaneethan Radhakrishnan, i dr.
Izdano: (2022-01-01)

Caffeic Acid Phenethyl Ester Reduces the Adverse Effects of Nicotine on the Endometrium
od: Amin Namdari, i dr.
Izdano: (2023-09-01)

Use of caffeic acid phenethyl ester and cortisone may prevent proliferative vitreoretinopathy
od: Yusuf Turkoz, i dr.
Izdano: (2004-01-01)

Bone resorption, matrix metalloproteinases and caffeic acid phenethyl ester
od: Sumeyya Akyol, i dr.
Izdano: (2016-12-01)

Why is Mortalin a Potential Therapeutic Target for Cancer?
od: A-Rum Yoon, i dr.
Izdano: (2022-06-01)

Promising influences of caffeic acid and caffeic acid phenethyl ester against natural and chemical toxins: A comprehensive and mechanistic review
od: Sajjad Ehtiati, i dr.
Izdano: (2023-08-01)

The Pluripotent Activities of Caffeic Acid Phenethyl Ester
od: Batoryna Olgierd, i dr.
Izdano: (2021-03-01)

Protective Effect of Caffeic Acid Phenethyl Ester in Rat Cerebral Ischemia/Reperfusion Damage
od: Ertuğrul Uzar, i dr.
Izdano: (2011-09-01)

Protective Effect of Caffeic Acid Phenethyl Ester in Rat Cerebral Ischemia/Reperfusion Damage
od: Ertuğrul Uzar, i dr.
Izdano: (2011-09-01)

Caffeic acid phenethyl ester inhibits multispecies biofilm formation and cariogenicity
od: Paopanga Kokilakanit, i dr.
Izdano: (2025-02-01)

Caffeic Acid Phenethyl Ester Administration Reduces Enterotoxigenic <i>Bacteroides fragilis</i>-Induced Colitis and Tumorigenesis
od: Soonjae Hwang, i dr.
Izdano: (2024-09-01)

Caffeic Acid Phenethyl Ester Assisted by Reversible Electroporation—In Vitro Study on Human Melanoma Cells
od: Anna Choromanska, i dr.
Izdano: (2020-05-01)

Caffeic Acid Phenethyl Ester (CAPE) Synergistically Enhances Paclitaxel Activity in Ovarian Cancer Cells
od: Anna Kleczka, i dr.
Izdano: (2023-08-01)

The protective effect of caffeic acid phenethyl ester in the nephrotoxicity induced by α-cypermethrin
od: Nur Gokhan, i dr.
Izdano: (2023-08-01)

Effect of Ashwagandha Withanolides on Muscle Cell Differentiation
od: Jia Wang, i dr.
Izdano: (2021-10-01)

The Immunoregulatory Effects of Caffeic Acid Phenethyl Ester on the Cytokine Secretion of Peripheral Blood Mononuclear Cells From Asthmatic Children
od: Leticia Bautista Sy, i dr.
Izdano: (2011-12-01)

Bioactivity and Chemical Synthesis of Caffeic Acid Phenethyl Ester and Its Derivatives
od: Pengxuan Zhang, i dr.
Izdano: (2014-10-01)

Research progress on synthesis and application of caffeic acid phenethyl ester in propolis
od: Meimei ZHANG, i dr.
Izdano: (2020-12-01)

Attenuating effects of caffeic acid phenethyl ester with intralipid on hepatotoxicity of chlorpyrifos in the case of rats
od: Recep Dokuyucu, i dr.
Izdano: (2016-12-01)

Caffeic Acid Phenethyl Ester and Ethanol Extract of Propolis Induce the Complementary Cytotoxic Effect on Triple-Negative Breast Cancer Cell Lines
od: Anna Rzepecka-Stojko, i dr.
Izdano: (2015-05-01)

The neuroprotective effects of caffeic acid phenethyl ester against methamphetamine-induced neurotoxicity
od: Bin Yang, i dr.
Izdano: (2024-07-01)

In Vitro Activity of Caffeic Acid Phenethyl Ester against Different Oral Microorganisms
od: Rasha AlSheikh, i dr.
Izdano: (2022-04-01)

Impact of Caffeic Acid Phenethyl Ester on Spinal Cord Inflammation in Mice Model of Multiple Sclerosis
od: Amin Alnawajha, i dr.
Izdano: (2024-07-01)

Effects of Caffeic Acid Phenethyl Ester on Embryonic Development Through Regulation of Mitochondria and Endoplasmic Reticulum
od: Chu-Man Huang, i dr.
Izdano: (2024-12-01)

Protective effects of caffeic acid phenethyl ester (CAPE) and thymoquinone against cigarette smoke in experimental bone fracture healing
od: Izzet Acikan, i dr.
Izdano: (2022-09-01)

Evaluation of antioxidant activity of caffeic acid phenethyl ester loaded block copolymer micelles
od: Krassimira Yoncheva, i dr.
Izdano: (2019-01-01)

Effects of Temperature, Metal Ions and Biosurfactants on Interaction Mechanism between Caffeic Acid Phenethyl Ester and Hemoglobin
od: Yutong Li, i dr.
Izdano: (2023-04-01)

Caffeic Acid Phenethyl Ester With Mesenchymal Stem Cells Improves Behavioral and Histopathological Changes in the Rat Model of Parkinson Disease
od: Khojasteh Rahimi Jaberi, i dr.
Izdano: (2022-09-01)

“One Pot” Enzymatic Synthesis of Caffeic Acid Phenethyl Ester in Deep Eutectic Solvent
od: Maria Roberta Tripon, i dr.
Izdano: (2025-01-01)

Caffeic acid phenethyl ester attenuates neuropathic pain by suppressing the p38/NF-κB signal pathway in microglia
od: Cheng H, i dr.
Izdano: (2018-11-01)

Redox-Responsive Crosslinked Mixed Micelles for Controllable Release of Caffeic Acid Phenethyl Ester
od: Katya Kamenova, i dr.
Izdano: (2022-03-01)

Comparison Study of the Influence of Caffeic Acid Phenethyl Ester and Mitoxantrone in Experimental Autoimmune Encephalomyelitis Balb/C Mice Model
od: Amin Alnawajha, i dr.
Izdano: (2023-10-01)

Beneficial Effects of Caffeic Acid Phenethyl Ester on Wound Healing in a Diabetic Mouse: Role of VEGF and NO
od: Sin-Hee Park, i dr.
Izdano: (2022-02-01)

Caffeic Acid Phenethyl Ester (CAPE): Biosynthesis, Derivatives and Formulations with Neuroprotective Activities
od: Rebeca Pérez, i dr.
Izdano: (2023-07-01)

Regulatory Effect of Caffeic Acid Phenethyl Ester on Oxidative Stress and Lipid Metabolism in HepG2 Cells
od: LIU Chang, CHANG Chao, CHEN Ruida, LIN Menghui, SUN Rong, CAI Chenggang, ZHAO Minjie, CAI Haiying
Izdano: (2023-09-01)

Caffeic Acid Phenethyl Ester Protects Kidney Mitochondria against Ischemia/Reperfusion Induced Injury in an <i>In Vivo</i> Rat Model
od: Justina Kamarauskaite, i dr.
Izdano: (2021-05-01)

Caffeic Acid Phenethyl Ester (CAPE) Induced Apoptosis in Serous Ovarian Cancer OV7 Cells by Deregulation of BCL2/BAX Genes
od: Anna Kleczka, i dr.
Izdano: (2020-07-01)

Protective and anti-inflammatory effects of caffeic acid phenethyl ester on arsenic-induced vasculitis in vivo
od: Yasser Kofiah, i dr.
Izdano: (2025-02-01)