Computational Insights into the Potential of Withaferin-A, Withanone and Caffeic Acid Phenethyl Ester for Treatment of Aberrant-EGFR Driven Lung Cancers

Computational Insights into the Potential of Withaferin-A, Withanone and Caffeic Acid Phenethyl Ester for Treatment of Aberrant-EGFR Driven Lung Cancers

The anticancer activities of Withaferin-A (Wi-A) and Withanone (Wi-N) from Ashwagandha and Caffeic Acid Phenethyl Ester (CAPE) from honeybee propolis have been well documented. Here, we examined the binding potential of these natural compounds to inhibit the constitutive phosphorylation of epidermal...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Vidhi Malik, Vipul Kumar, Sunil C. Kaul, Renu Wadhwa, Durai Sundar
Формат:	Өгүүллэг
Хэл сонгох:	English
Хэвлэсэн:	MDPI AG 2021-01-01
Цуврал:	Biomolecules
Нөхцлүүд:	EGFR exon 20 insertion mutations Withaferin A Withanone Caffeic Acid Phenethyl Ester ATP competitive inhibitors
Онлайн хандалт:	https://www.mdpi.com/2218-273X/11/2/160

Ижил төстэй зүйлс

Potential of Withaferin-A, Withanone and Caffeic Acid Phenethyl ester as ATP-competitive inhibitors of BRAF: A bioinformatics study
-н: Vidhi Malik, зэрэг
Хэвлэсэн: (2021-01-01)

Computational Identification of BCR-ABL Oncogenic Signaling as a Candidate Target of Withaferin A and Withanone
-н: Vidhi Malik, зэрэг
Хэвлэсэн: (2022-01-01)

Phosphatidylserine Exposed Lipid Bilayer Models for Understanding Cancer Cell Selectivity of Natural Compounds: A Molecular Dynamics Simulation Study
-н: Navaneethan Radhakrishnan, зэрэг
Хэвлэсэн: (2022-01-01)

Caffeic Acid Phenethyl Ester Reduces the Adverse Effects of Nicotine on the Endometrium
-н: Amin Namdari, зэрэг
Хэвлэсэн: (2023-09-01)

Use of caffeic acid phenethyl ester and cortisone may prevent proliferative vitreoretinopathy
-н: Yusuf Turkoz, зэрэг
Хэвлэсэн: (2004-01-01)

Bone resorption, matrix metalloproteinases and caffeic acid phenethyl ester
-н: Sumeyya Akyol, зэрэг
Хэвлэсэн: (2016-12-01)

Why is Mortalin a Potential Therapeutic Target for Cancer?
-н: A-Rum Yoon, зэрэг
Хэвлэсэн: (2022-06-01)

Promising influences of caffeic acid and caffeic acid phenethyl ester against natural and chemical toxins: A comprehensive and mechanistic review
-н: Sajjad Ehtiati, зэрэг
Хэвлэсэн: (2023-08-01)

The Pluripotent Activities of Caffeic Acid Phenethyl Ester
-н: Batoryna Olgierd, зэрэг
Хэвлэсэн: (2021-03-01)

Protective Effect of Caffeic Acid Phenethyl Ester in Rat Cerebral Ischemia/Reperfusion Damage
-н: Ertuğrul Uzar, зэрэг
Хэвлэсэн: (2011-09-01)

Protective Effect of Caffeic Acid Phenethyl Ester in Rat Cerebral Ischemia/Reperfusion Damage
-н: Ertuğrul Uzar, зэрэг
Хэвлэсэн: (2011-09-01)

Caffeic acid phenethyl ester inhibits multispecies biofilm formation and cariogenicity
-н: Paopanga Kokilakanit, зэрэг
Хэвлэсэн: (2025-02-01)

Caffeic Acid Phenethyl Ester Administration Reduces Enterotoxigenic <i>Bacteroides fragilis</i>-Induced Colitis and Tumorigenesis
-н: Soonjae Hwang, зэрэг
Хэвлэсэн: (2024-09-01)

Caffeic Acid Phenethyl Ester Assisted by Reversible Electroporation—In Vitro Study on Human Melanoma Cells
-н: Anna Choromanska, зэрэг
Хэвлэсэн: (2020-05-01)

Caffeic Acid Phenethyl Ester (CAPE) Synergistically Enhances Paclitaxel Activity in Ovarian Cancer Cells
-н: Anna Kleczka, зэрэг
Хэвлэсэн: (2023-08-01)

The protective effect of caffeic acid phenethyl ester in the nephrotoxicity induced by α-cypermethrin
-н: Nur Gokhan, зэрэг
Хэвлэсэн: (2023-08-01)

Effect of Ashwagandha Withanolides on Muscle Cell Differentiation
-н: Jia Wang, зэрэг
Хэвлэсэн: (2021-10-01)

The Immunoregulatory Effects of Caffeic Acid Phenethyl Ester on the Cytokine Secretion of Peripheral Blood Mononuclear Cells From Asthmatic Children
-н: Leticia Bautista Sy, зэрэг
Хэвлэсэн: (2011-12-01)

Bioactivity and Chemical Synthesis of Caffeic Acid Phenethyl Ester and Its Derivatives
-н: Pengxuan Zhang, зэрэг
Хэвлэсэн: (2014-10-01)

Research progress on synthesis and application of caffeic acid phenethyl ester in propolis
-н: Meimei ZHANG, зэрэг
Хэвлэсэн: (2020-12-01)

Attenuating effects of caffeic acid phenethyl ester with intralipid on hepatotoxicity of chlorpyrifos in the case of rats
-н: Recep Dokuyucu, зэрэг
Хэвлэсэн: (2016-12-01)

Caffeic Acid Phenethyl Ester and Ethanol Extract of Propolis Induce the Complementary Cytotoxic Effect on Triple-Negative Breast Cancer Cell Lines
-н: Anna Rzepecka-Stojko, зэрэг
Хэвлэсэн: (2015-05-01)

The neuroprotective effects of caffeic acid phenethyl ester against methamphetamine-induced neurotoxicity
-н: Bin Yang, зэрэг
Хэвлэсэн: (2024-07-01)

In Vitro Activity of Caffeic Acid Phenethyl Ester against Different Oral Microorganisms
-н: Rasha AlSheikh, зэрэг
Хэвлэсэн: (2022-04-01)

Impact of Caffeic Acid Phenethyl Ester on Spinal Cord Inflammation in Mice Model of Multiple Sclerosis
-н: Amin Alnawajha, зэрэг
Хэвлэсэн: (2024-07-01)

Effects of Caffeic Acid Phenethyl Ester on Embryonic Development Through Regulation of Mitochondria and Endoplasmic Reticulum
-н: Chu-Man Huang, зэрэг
Хэвлэсэн: (2024-12-01)

Protective effects of caffeic acid phenethyl ester (CAPE) and thymoquinone against cigarette smoke in experimental bone fracture healing
-н: Izzet Acikan, зэрэг
Хэвлэсэн: (2022-09-01)

Evaluation of antioxidant activity of caffeic acid phenethyl ester loaded block copolymer micelles
-н: Krassimira Yoncheva, зэрэг
Хэвлэсэн: (2019-01-01)

Effects of Temperature, Metal Ions and Biosurfactants on Interaction Mechanism between Caffeic Acid Phenethyl Ester and Hemoglobin
-н: Yutong Li, зэрэг
Хэвлэсэн: (2023-04-01)

Caffeic Acid Phenethyl Ester With Mesenchymal Stem Cells Improves Behavioral and Histopathological Changes in the Rat Model of Parkinson Disease
-н: Khojasteh Rahimi Jaberi, зэрэг
Хэвлэсэн: (2022-09-01)

“One Pot” Enzymatic Synthesis of Caffeic Acid Phenethyl Ester in Deep Eutectic Solvent
-н: Maria Roberta Tripon, зэрэг
Хэвлэсэн: (2025-01-01)

Caffeic acid phenethyl ester attenuates neuropathic pain by suppressing the p38/NF-κB signal pathway in microglia
-н: Cheng H, зэрэг
Хэвлэсэн: (2018-11-01)

Redox-Responsive Crosslinked Mixed Micelles for Controllable Release of Caffeic Acid Phenethyl Ester
-н: Katya Kamenova, зэрэг
Хэвлэсэн: (2022-03-01)

Comparison Study of the Influence of Caffeic Acid Phenethyl Ester and Mitoxantrone in Experimental Autoimmune Encephalomyelitis Balb/C Mice Model
-н: Amin Alnawajha, зэрэг
Хэвлэсэн: (2023-10-01)

Beneficial Effects of Caffeic Acid Phenethyl Ester on Wound Healing in a Diabetic Mouse: Role of VEGF and NO
-н: Sin-Hee Park, зэрэг
Хэвлэсэн: (2022-02-01)

Caffeic Acid Phenethyl Ester (CAPE): Biosynthesis, Derivatives and Formulations with Neuroprotective Activities
-н: Rebeca Pérez, зэрэг
Хэвлэсэн: (2023-07-01)

Regulatory Effect of Caffeic Acid Phenethyl Ester on Oxidative Stress and Lipid Metabolism in HepG2 Cells
-н: LIU Chang, CHANG Chao, CHEN Ruida, LIN Menghui, SUN Rong, CAI Chenggang, ZHAO Minjie, CAI Haiying
Хэвлэсэн: (2023-09-01)

Caffeic Acid Phenethyl Ester Protects Kidney Mitochondria against Ischemia/Reperfusion Induced Injury in an <i>In Vivo</i> Rat Model
-н: Justina Kamarauskaite, зэрэг
Хэвлэсэн: (2021-05-01)

Caffeic Acid Phenethyl Ester (CAPE) Induced Apoptosis in Serous Ovarian Cancer OV7 Cells by Deregulation of BCL2/BAX Genes
-н: Anna Kleczka, зэрэг
Хэвлэсэн: (2020-07-01)

Protective and anti-inflammatory effects of caffeic acid phenethyl ester on arsenic-induced vasculitis in vivo
-н: Yasser Kofiah, зэрэг
Хэвлэсэн: (2025-02-01)