Computational Insights into the Potential of Withaferin-A, Withanone and Caffeic Acid Phenethyl Ester for Treatment of Aberrant-EGFR Driven Lung Cancers

Computational Insights into the Potential of Withaferin-A, Withanone and Caffeic Acid Phenethyl Ester for Treatment of Aberrant-EGFR Driven Lung Cancers

The anticancer activities of Withaferin-A (Wi-A) and Withanone (Wi-N) from Ashwagandha and Caffeic Acid Phenethyl Ester (CAPE) from honeybee propolis have been well documented. Here, we examined the binding potential of these natural compounds to inhibit the constitutive phosphorylation of epidermal...

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Autors principals: Vidhi Malik, Vipul Kumar, Sunil C. Kaul, Renu Wadhwa, Durai Sundar
Format: Article
Idioma:English
Publicat: MDPI AG 2021-01-01
Col·lecció:Biomolecules
Matèries:
EGFR
exon 20 insertion mutations
Withaferin A
Withanone
Caffeic Acid Phenethyl Ester
ATP competitive inhibitors
Accés en línia:https://www.mdpi.com/2218-273X/11/2/160

Internet

https://www.mdpi.com/2218-273X/11/2/160

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