Frequency of Iatrogenic Sexual Dysfunction Associated with Antihypertensive Compounds
Iatrogenic sexual dysfunction (SD) caused by antihypertensive (AH) compounds, provoking sexual desire, orgasm or arousal dysfunction, is a common clinical adverse event. Unfortunately, it is often underestimated and underreported by clinicians and prescribers in clinical practice, deteriorating the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/22/5214 |
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| author | Bárbara Buch-Vicente José Mª. Acosta José-Angel Martín-Oterino Nieves Prieto María Elena Sánchez-Sánchez Purificación Galindo-Villardón Angel L. Montejo |
| author_facet | Bárbara Buch-Vicente José Mª. Acosta José-Angel Martín-Oterino Nieves Prieto María Elena Sánchez-Sánchez Purificación Galindo-Villardón Angel L. Montejo |
| author_sort | Bárbara Buch-Vicente |
| collection | DOAJ |
| description | Iatrogenic sexual dysfunction (SD) caused by antihypertensive (AH) compounds, provoking sexual desire, orgasm or arousal dysfunction, is a common clinical adverse event. Unfortunately, it is often underestimated and underreported by clinicians and prescribers in clinical practice, deteriorating the adherence and patient quality of life. The objective of this study was to investigate the frequency of SD in patients treated with different antihypertensive compounds; a real-life naturalistic and cross-sectional study in patients receiving AH treatment was carried out. Method: A total of 256 patients were included in the study (188 males and 68 females who met the inclusion and exclusion criteria). The validated Psychotropic-Related Sexual Dysfunction Questionnaire (PRSexDQ-SALSEX) was transversally applied once at least every two months following the onset of the treatment in order to measure possible AH-related SD. Although the spontaneous reporting of SD was very low (6.81% females/24.8% males), 66.40% of the patients reported impaired sexual function through the SALSEX questionnaire after the treatment onset, as follows: decreased desire (55.8% females/54.2% males), delayed orgasm (42.6%/45.7%), anorgasmia (42.6%/43.6%) and arousal difficulties (53%/59.6%). The average frequency of moderate to severe iatrogenic SD was 66.4% with AH in monotherapy as follows: angiotensin II receptor antagonists (ARBs), 29.8%; calcium antagonists, 40%; diuretics, 42.9%; beta blockers, 43.8%; and angiotensin-converting enzyme (ACE) inhibitors, 77.8%. Combined treatments showed a higher percentage of main SD (70.3%): diuretic + ACE inhibitor, 42.3%; ARB + calcium antagonist, 55.6%; diuretic + calcium antagonist, 68.8%; and diuretic + ARB, 74.2%. The greatest risk factors associated with SD were poor general health, age over 60 with a comorbid coronary or musculoskeletal disease, mood disorder and diuretic +ARB combined therapy. Conclusion: SD is common in patients treated with antihypertensive drugs, and it is still underreported. The most harmful treatment deteriorating sexual function was the combination of diuretic +ARB, while the least harmful was monotherapy with ARBs. More research is needed on the clinical management of this problem to preserve the quality of life of patients and their partners. |
| first_indexed | 2024-03-10T05:24:58Z |
| format | Article |
| id | doaj.art-ab0a393db3ca4bbabcf5f683f4a96759 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T05:24:58Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-ab0a393db3ca4bbabcf5f683f4a967592023-11-22T23:48:06ZengMDPI AGJournal of Clinical Medicine2077-03832021-11-011022521410.3390/jcm10225214Frequency of Iatrogenic Sexual Dysfunction Associated with Antihypertensive CompoundsBárbara Buch-Vicente0José Mª. Acosta1José-Angel Martín-Oterino2Nieves Prieto3María Elena Sánchez-Sánchez4Purificación Galindo-Villardón5Angel L. Montejo6Instituto Investigación Biomédica de Salamanca (IBSAL), Paseo San Vicente SN, 37007 Salamanca, SpainInstituto Investigación Biomédica de Salamanca (IBSAL), Paseo San Vicente SN, 37007 Salamanca, SpainInternal Medicine Service, Clinical Hospital of Salamanca, Paseo San Vicente SN, 37007 Salamanca, SpainInstituto Investigación Biomédica de Salamanca (IBSAL), Paseo San Vicente SN, 37007 Salamanca, SpainInstituto Investigación Biomédica de Salamanca (IBSAL), Paseo San Vicente SN, 37007 Salamanca, SpainStatistical Department, Campus Miguel de Unamuno, University of Salamanca, Calle Alfonso X El Sabio s/n, 37007 Salamanca, SpainInstituto Investigación Biomédica de Salamanca (IBSAL), Paseo San Vicente SN, 37007 Salamanca, SpainIatrogenic sexual dysfunction (SD) caused by antihypertensive (AH) compounds, provoking sexual desire, orgasm or arousal dysfunction, is a common clinical adverse event. Unfortunately, it is often underestimated and underreported by clinicians and prescribers in clinical practice, deteriorating the adherence and patient quality of life. The objective of this study was to investigate the frequency of SD in patients treated with different antihypertensive compounds; a real-life naturalistic and cross-sectional study in patients receiving AH treatment was carried out. Method: A total of 256 patients were included in the study (188 males and 68 females who met the inclusion and exclusion criteria). The validated Psychotropic-Related Sexual Dysfunction Questionnaire (PRSexDQ-SALSEX) was transversally applied once at least every two months following the onset of the treatment in order to measure possible AH-related SD. Although the spontaneous reporting of SD was very low (6.81% females/24.8% males), 66.40% of the patients reported impaired sexual function through the SALSEX questionnaire after the treatment onset, as follows: decreased desire (55.8% females/54.2% males), delayed orgasm (42.6%/45.7%), anorgasmia (42.6%/43.6%) and arousal difficulties (53%/59.6%). The average frequency of moderate to severe iatrogenic SD was 66.4% with AH in monotherapy as follows: angiotensin II receptor antagonists (ARBs), 29.8%; calcium antagonists, 40%; diuretics, 42.9%; beta blockers, 43.8%; and angiotensin-converting enzyme (ACE) inhibitors, 77.8%. Combined treatments showed a higher percentage of main SD (70.3%): diuretic + ACE inhibitor, 42.3%; ARB + calcium antagonist, 55.6%; diuretic + calcium antagonist, 68.8%; and diuretic + ARB, 74.2%. The greatest risk factors associated with SD were poor general health, age over 60 with a comorbid coronary or musculoskeletal disease, mood disorder and diuretic +ARB combined therapy. Conclusion: SD is common in patients treated with antihypertensive drugs, and it is still underreported. The most harmful treatment deteriorating sexual function was the combination of diuretic +ARB, while the least harmful was monotherapy with ARBs. More research is needed on the clinical management of this problem to preserve the quality of life of patients and their partners.https://www.mdpi.com/2077-0383/10/22/5214sexual dysfunctionantihypertensive treatmenthypertensionPRSexDQ-SALSEXblood pressure |
| spellingShingle | Bárbara Buch-Vicente José Mª. Acosta José-Angel Martín-Oterino Nieves Prieto María Elena Sánchez-Sánchez Purificación Galindo-Villardón Angel L. Montejo Frequency of Iatrogenic Sexual Dysfunction Associated with Antihypertensive Compounds Journal of Clinical Medicine sexual dysfunction antihypertensive treatment hypertension PRSexDQ-SALSEX blood pressure |
| title | Frequency of Iatrogenic Sexual Dysfunction Associated with Antihypertensive Compounds |
| title_full | Frequency of Iatrogenic Sexual Dysfunction Associated with Antihypertensive Compounds |
| title_fullStr | Frequency of Iatrogenic Sexual Dysfunction Associated with Antihypertensive Compounds |
| title_full_unstemmed | Frequency of Iatrogenic Sexual Dysfunction Associated with Antihypertensive Compounds |
| title_short | Frequency of Iatrogenic Sexual Dysfunction Associated with Antihypertensive Compounds |
| title_sort | frequency of iatrogenic sexual dysfunction associated with antihypertensive compounds |
| topic | sexual dysfunction antihypertensive treatment hypertension PRSexDQ-SALSEX blood pressure |
| url | https://www.mdpi.com/2077-0383/10/22/5214 |
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