Effect of Eight Weeks of Endurance Training on the Protein Levels of Some Angiogenesis Indicators in the Cardiac Tissue of Rats with Morphine Withdrawal Syndrome
Background: Exercise is a therapeutic procedure for addicts; however, its physiological mechanisms are not well understood. This study aimed to investigate the effect of eight weeks of endurance training on the levels of vascular endothelial growth factor and endostatin in the heart tissue of male r...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Lorestan University of Medical Science
2023-05-01
|
| Series: | Yafteh |
| Subjects: | |
| Online Access: | http://yafte.lums.ac.ir/article-1-3623-en.pdf |
| _version_ | 1797779136271351808 |
|---|---|
| author | Katayoon Sahraneshin Abbas Saremi Mohammad Malekipouya |
| author_facet | Katayoon Sahraneshin Abbas Saremi Mohammad Malekipouya |
| author_sort | Katayoon Sahraneshin |
| collection | DOAJ |
| description | Background: Exercise is a therapeutic procedure for addicts; however, its physiological mechanisms are not well understood. This study aimed to investigate the effect of eight weeks of endurance training on the levels of vascular endothelial growth factor and endostatin in the heart tissue of male rats with morphine withdrawal syndrome.
Materials and Methods: This experimental study was conducted on 32 male rats randomly divided into four groups of eight: healthy control (HC), endurance training (ET), morphine control (CM), and morphine+endurance training (M.ET). Two morphine withdrawal groups were addicted to 0.4 mg/ml morphine sulfate for 21 days. The exercise groups performed eight weeks of treadmill running. At the end of the study, all rats were killed, and their heart tissue was removed. Protein levels of the indicators in this study were measured by ELISA kits. The data were analyzed by Tukey’s one-way ANOVA test.
Results: The results of this study showed a significant decrease in VEGF levels (P<0.001) and a significant increase in ES (P<0.001) in the MC, compared to the HC. In addition, the increase in VEGF levels (P=0.014) and the decrease in ES (P=0.026) in the M.ET showed a significant difference, compared to the MC.
Conclusion: Endurance training may be useful in preventing negative changes in angiogenesis and metabolic parameters related to morphine, which should be considered in the rehabilitation of addicts. |
| first_indexed | 2024-03-12T23:27:24Z |
| format | Article |
| id | doaj.art-ab0b7646a39f487ea54c4a144caf900a |
| institution | Directory Open Access Journal |
| issn | 1563-0773 |
| language | fas |
| last_indexed | 2024-03-12T23:27:24Z |
| publishDate | 2023-05-01 |
| publisher | Lorestan University of Medical Science |
| record_format | Article |
| series | Yafteh |
| spelling | doaj.art-ab0b7646a39f487ea54c4a144caf900a2023-07-16T07:22:25ZfasLorestan University of Medical ScienceYafteh1563-07732023-05-012514758Effect of Eight Weeks of Endurance Training on the Protein Levels of Some Angiogenesis Indicators in the Cardiac Tissue of Rats with Morphine Withdrawal SyndromeKatayoon Sahraneshin0Abbas Saremi1Mohammad Malekipouya2 Department of Physical Education, Borujerd Branch, Islamic Azad University, Borujerd, Iran Department of Exercise Physiology, Faculty of Sport Sciences, Arak University, Arak, Iran Department of Physical Education, Borujerd Branch, Islamic Azad University, Borujerd, Iran Background: Exercise is a therapeutic procedure for addicts; however, its physiological mechanisms are not well understood. This study aimed to investigate the effect of eight weeks of endurance training on the levels of vascular endothelial growth factor and endostatin in the heart tissue of male rats with morphine withdrawal syndrome. Materials and Methods: This experimental study was conducted on 32 male rats randomly divided into four groups of eight: healthy control (HC), endurance training (ET), morphine control (CM), and morphine+endurance training (M.ET). Two morphine withdrawal groups were addicted to 0.4 mg/ml morphine sulfate for 21 days. The exercise groups performed eight weeks of treadmill running. At the end of the study, all rats were killed, and their heart tissue was removed. Protein levels of the indicators in this study were measured by ELISA kits. The data were analyzed by Tukey’s one-way ANOVA test. Results: The results of this study showed a significant decrease in VEGF levels (P<0.001) and a significant increase in ES (P<0.001) in the MC, compared to the HC. In addition, the increase in VEGF levels (P=0.014) and the decrease in ES (P=0.026) in the M.ET showed a significant difference, compared to the MC. Conclusion: Endurance training may be useful in preventing negative changes in angiogenesis and metabolic parameters related to morphine, which should be considered in the rehabilitation of addicts.http://yafte.lums.ac.ir/article-1-3623-en.pdfangiogenesiscardiac tissueendurance exercisemorphine withdrawal syndrome |
| spellingShingle | Katayoon Sahraneshin Abbas Saremi Mohammad Malekipouya Effect of Eight Weeks of Endurance Training on the Protein Levels of Some Angiogenesis Indicators in the Cardiac Tissue of Rats with Morphine Withdrawal Syndrome Yafteh angiogenesis cardiac tissue endurance exercise morphine withdrawal syndrome |
| title | Effect of Eight Weeks of Endurance Training on the Protein Levels of Some Angiogenesis Indicators in the Cardiac Tissue of Rats with Morphine Withdrawal Syndrome |
| title_full | Effect of Eight Weeks of Endurance Training on the Protein Levels of Some Angiogenesis Indicators in the Cardiac Tissue of Rats with Morphine Withdrawal Syndrome |
| title_fullStr | Effect of Eight Weeks of Endurance Training on the Protein Levels of Some Angiogenesis Indicators in the Cardiac Tissue of Rats with Morphine Withdrawal Syndrome |
| title_full_unstemmed | Effect of Eight Weeks of Endurance Training on the Protein Levels of Some Angiogenesis Indicators in the Cardiac Tissue of Rats with Morphine Withdrawal Syndrome |
| title_short | Effect of Eight Weeks of Endurance Training on the Protein Levels of Some Angiogenesis Indicators in the Cardiac Tissue of Rats with Morphine Withdrawal Syndrome |
| title_sort | effect of eight weeks of endurance training on the protein levels of some angiogenesis indicators in the cardiac tissue of rats with morphine withdrawal syndrome |
| topic | angiogenesis cardiac tissue endurance exercise morphine withdrawal syndrome |
| url | http://yafte.lums.ac.ir/article-1-3623-en.pdf |
| work_keys_str_mv | AT katayoonsahraneshin effectofeightweeksofendurancetrainingontheproteinlevelsofsomeangiogenesisindicatorsinthecardiactissueofratswithmorphinewithdrawalsyndrome AT abbassaremi effectofeightweeksofendurancetrainingontheproteinlevelsofsomeangiogenesisindicatorsinthecardiactissueofratswithmorphinewithdrawalsyndrome AT mohammadmalekipouya effectofeightweeksofendurancetrainingontheproteinlevelsofsomeangiogenesisindicatorsinthecardiactissueofratswithmorphinewithdrawalsyndrome |