Hepatitis C virus in hemophilia: Health‐related quality of life after successful treatment in the sixth Hemophilia in the Netherlands study
Abstract Introduction Persons with hemophilia and hepatitis C virus (HCV) infection have a lower health‐related quality of life (HRQoL) than those never HCV infected. However, it is unknown whether HRQoL after HCV eradication is comparable to individuals never HCV infected. We aimed to compare HRQoL...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-12-01
|
| Series: | Research and Practice in Thrombosis and Haemostasis |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rth2.12616 |
| _version_ | 1827854259003064320 |
|---|---|
| author | Cas J. Isfordink Samantha C. Gouw Erna C. vanBalen Shermarke Hassan Erik A. M. Beckers Johanna G. van derBom Michiel Coppens Jeroen Eikenboom Kathelijn Fischer Louise Hooimeijer Frank W. G. Leebeek Frits R. Rosendaal Saskia E. M. Schols Cees Smit Lize F. D. vanVulpen Eveline P. Mauser‐Bunschoten |
| author_facet | Cas J. Isfordink Samantha C. Gouw Erna C. vanBalen Shermarke Hassan Erik A. M. Beckers Johanna G. van derBom Michiel Coppens Jeroen Eikenboom Kathelijn Fischer Louise Hooimeijer Frank W. G. Leebeek Frits R. Rosendaal Saskia E. M. Schols Cees Smit Lize F. D. vanVulpen Eveline P. Mauser‐Bunschoten |
| author_sort | Cas J. Isfordink |
| collection | DOAJ |
| description | Abstract Introduction Persons with hemophilia and hepatitis C virus (HCV) infection have a lower health‐related quality of life (HRQoL) than those never HCV infected. However, it is unknown whether HRQoL after HCV eradication is comparable to individuals never HCV infected. We aimed to compare HRQoL between HCV‐cured and never chronically HCV‐infected persons with hemophilia. Methods All persons with hemophilia in the Netherlands were invited for a nationwide study conducted in 2018–2019. For the current analysis, participants born before 1992 with data on HRQoL and HCV status were included. HCV status was collected from medical records. HRQoL was measured by RAND‐36 questionnaire, with a minimally important difference set at 4.0 points. Multivariable linear regression was used to adjust for age, hemophilia severity, HIV status, and self‐reported joint impairment. Results In total, 486 persons were eligible; 180 were HCV cured and 306 never chronically HCV infected. Compared with those never HCV infected, HCV‐cured individuals were older (57 vs. 53 years), more often had severe hemophilia (67% vs. 21%), and reported more impaired joints (median 3 vs. 0). Compared with those never HCV infected, adjusted RAND‐36 domain scores of HCV‐cured individuals cured were lower on all RAND‐36 domains except Pain, ranging from a difference of 4.5 (95% CI, −8.8 to −0.3) for Physical functioning to 11.3 (95% CI, −19.4 to −3.1) for Role limitations due to physical problems. Conclusion Despite effective HCV treatment, HRQoL of HCV‐cured persons with hemophilia is still lower than HRQoL of those never chronically HCV‐infected on all RAND‐36 domains. This implies that careful psychosocial follow‐up and support are indicated. |
| first_indexed | 2024-03-12T11:17:55Z |
| format | Article |
| id | doaj.art-ab0b8a7c6e744fb3b209acf2c9b4bb45 |
| institution | Directory Open Access Journal |
| issn | 2475-0379 |
| language | English |
| last_indexed | 2024-03-12T11:17:55Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Research and Practice in Thrombosis and Haemostasis |
| spelling | doaj.art-ab0b8a7c6e744fb3b209acf2c9b4bb452023-09-02T01:42:12ZengElsevierResearch and Practice in Thrombosis and Haemostasis2475-03792021-12-0158n/an/a10.1002/rth2.12616Hepatitis C virus in hemophilia: Health‐related quality of life after successful treatment in the sixth Hemophilia in the Netherlands studyCas J. Isfordink0Samantha C. Gouw1Erna C. vanBalen2Shermarke Hassan3Erik A. M. Beckers4Johanna G. van derBom5Michiel Coppens6Jeroen Eikenboom7Kathelijn Fischer8Louise Hooimeijer9Frank W. G. Leebeek10Frits R. Rosendaal11Saskia E. M. Schols12Cees Smit13Lize F. D. vanVulpen14Eveline P. Mauser‐Bunschoten15Van Creveldkliniek Center for Benign Haematology University Medical Center Utrecht Utrecht University Utrecht The NetherlandsDepartment of Clinical Epidemiology Leiden University Medical Center Leiden The NetherlandsDepartment of Clinical Epidemiology Leiden University Medical Center Leiden The NetherlandsDepartment of Clinical Epidemiology Leiden University Medical Center Leiden The NetherlandsDepartment of Hematology Maastricht University Medical Centre Maastricht The NetherlandsDepartment of Clinical Epidemiology Leiden University Medical Center Leiden The NetherlandsDepartment of Vascular Medicine Amsterdam Cardiovascular Sciences Amsterdam University Medical Centres University of Amsterdam Amsterdam The NetherlandsDivision of Thrombosis and Hemostasis Department of Internal Medicine Leiden University Medical Center Leiden The NetherlandsVan Creveldkliniek Center for Benign Haematology University Medical Center Utrecht Utrecht University Utrecht The NetherlandsDepartment of Paediatrics University Medical Center Groningen Groningen The NetherlandsDepartment of Hematology Erasmus University Medical Center Rotterdam The NetherlandsDepartment of Clinical Epidemiology Leiden University Medical Center Leiden The NetherlandsDepartment of Hematology Radboud University Medical Center Nijmegen The NetherlandsDepartment of Clinical Epidemiology Leiden University Medical Center Leiden The NetherlandsVan Creveldkliniek Center for Benign Haematology University Medical Center Utrecht Utrecht University Utrecht The NetherlandsVan Creveldkliniek Center for Benign Haematology University Medical Center Utrecht Utrecht University Utrecht The NetherlandsAbstract Introduction Persons with hemophilia and hepatitis C virus (HCV) infection have a lower health‐related quality of life (HRQoL) than those never HCV infected. However, it is unknown whether HRQoL after HCV eradication is comparable to individuals never HCV infected. We aimed to compare HRQoL between HCV‐cured and never chronically HCV‐infected persons with hemophilia. Methods All persons with hemophilia in the Netherlands were invited for a nationwide study conducted in 2018–2019. For the current analysis, participants born before 1992 with data on HRQoL and HCV status were included. HCV status was collected from medical records. HRQoL was measured by RAND‐36 questionnaire, with a minimally important difference set at 4.0 points. Multivariable linear regression was used to adjust for age, hemophilia severity, HIV status, and self‐reported joint impairment. Results In total, 486 persons were eligible; 180 were HCV cured and 306 never chronically HCV infected. Compared with those never HCV infected, HCV‐cured individuals were older (57 vs. 53 years), more often had severe hemophilia (67% vs. 21%), and reported more impaired joints (median 3 vs. 0). Compared with those never HCV infected, adjusted RAND‐36 domain scores of HCV‐cured individuals cured were lower on all RAND‐36 domains except Pain, ranging from a difference of 4.5 (95% CI, −8.8 to −0.3) for Physical functioning to 11.3 (95% CI, −19.4 to −3.1) for Role limitations due to physical problems. Conclusion Despite effective HCV treatment, HRQoL of HCV‐cured persons with hemophilia is still lower than HRQoL of those never chronically HCV‐infected on all RAND‐36 domains. This implies that careful psychosocial follow‐up and support are indicated.https://doi.org/10.1002/rth2.12616direct‐acting antiviralshepatitis C virushemophilia Ahemophilia Bpatient reported outcome measuresRAND‐36 |
| spellingShingle | Cas J. Isfordink Samantha C. Gouw Erna C. vanBalen Shermarke Hassan Erik A. M. Beckers Johanna G. van derBom Michiel Coppens Jeroen Eikenboom Kathelijn Fischer Louise Hooimeijer Frank W. G. Leebeek Frits R. Rosendaal Saskia E. M. Schols Cees Smit Lize F. D. vanVulpen Eveline P. Mauser‐Bunschoten Hepatitis C virus in hemophilia: Health‐related quality of life after successful treatment in the sixth Hemophilia in the Netherlands study Research and Practice in Thrombosis and Haemostasis direct‐acting antivirals hepatitis C virus hemophilia A hemophilia B patient reported outcome measures RAND‐36 |
| title | Hepatitis C virus in hemophilia: Health‐related quality of life after successful treatment in the sixth Hemophilia in the Netherlands study |
| title_full | Hepatitis C virus in hemophilia: Health‐related quality of life after successful treatment in the sixth Hemophilia in the Netherlands study |
| title_fullStr | Hepatitis C virus in hemophilia: Health‐related quality of life after successful treatment in the sixth Hemophilia in the Netherlands study |
| title_full_unstemmed | Hepatitis C virus in hemophilia: Health‐related quality of life after successful treatment in the sixth Hemophilia in the Netherlands study |
| title_short | Hepatitis C virus in hemophilia: Health‐related quality of life after successful treatment in the sixth Hemophilia in the Netherlands study |
| title_sort | hepatitis c virus in hemophilia health related quality of life after successful treatment in the sixth hemophilia in the netherlands study |
| topic | direct‐acting antivirals hepatitis C virus hemophilia A hemophilia B patient reported outcome measures RAND‐36 |
| url | https://doi.org/10.1002/rth2.12616 |
| work_keys_str_mv | AT casjisfordink hepatitiscvirusinhemophiliahealthrelatedqualityoflifeaftersuccessfultreatmentinthesixthhemophiliainthenetherlandsstudy AT samanthacgouw hepatitiscvirusinhemophiliahealthrelatedqualityoflifeaftersuccessfultreatmentinthesixthhemophiliainthenetherlandsstudy AT ernacvanbalen hepatitiscvirusinhemophiliahealthrelatedqualityoflifeaftersuccessfultreatmentinthesixthhemophiliainthenetherlandsstudy AT shermarkehassan hepatitiscvirusinhemophiliahealthrelatedqualityoflifeaftersuccessfultreatmentinthesixthhemophiliainthenetherlandsstudy AT erikambeckers hepatitiscvirusinhemophiliahealthrelatedqualityoflifeaftersuccessfultreatmentinthesixthhemophiliainthenetherlandsstudy AT johannagvanderbom hepatitiscvirusinhemophiliahealthrelatedqualityoflifeaftersuccessfultreatmentinthesixthhemophiliainthenetherlandsstudy AT michielcoppens hepatitiscvirusinhemophiliahealthrelatedqualityoflifeaftersuccessfultreatmentinthesixthhemophiliainthenetherlandsstudy AT jeroeneikenboom hepatitiscvirusinhemophiliahealthrelatedqualityoflifeaftersuccessfultreatmentinthesixthhemophiliainthenetherlandsstudy AT kathelijnfischer hepatitiscvirusinhemophiliahealthrelatedqualityoflifeaftersuccessfultreatmentinthesixthhemophiliainthenetherlandsstudy AT louisehooimeijer hepatitiscvirusinhemophiliahealthrelatedqualityoflifeaftersuccessfultreatmentinthesixthhemophiliainthenetherlandsstudy AT frankwgleebeek hepatitiscvirusinhemophiliahealthrelatedqualityoflifeaftersuccessfultreatmentinthesixthhemophiliainthenetherlandsstudy AT fritsrrosendaal hepatitiscvirusinhemophiliahealthrelatedqualityoflifeaftersuccessfultreatmentinthesixthhemophiliainthenetherlandsstudy AT saskiaemschols hepatitiscvirusinhemophiliahealthrelatedqualityoflifeaftersuccessfultreatmentinthesixthhemophiliainthenetherlandsstudy AT ceessmit hepatitiscvirusinhemophiliahealthrelatedqualityoflifeaftersuccessfultreatmentinthesixthhemophiliainthenetherlandsstudy AT lizefdvanvulpen hepatitiscvirusinhemophiliahealthrelatedqualityoflifeaftersuccessfultreatmentinthesixthhemophiliainthenetherlandsstudy AT evelinepmauserbunschoten hepatitiscvirusinhemophiliahealthrelatedqualityoflifeaftersuccessfultreatmentinthesixthhemophiliainthenetherlandsstudy |