Associations Between Eczema and Attention Deficit Hyperactivity Disorder Symptoms in Children
BackgroundEpidemiological studies suggest a link between eczema and attention deficit hyperactivity disorder (ADHD), but underlying mechanisms have not been examined.ObjectiveWe aim to investigate the association between eczema and subsequent ADHD symptoms in the Growing Up in Singapore Towards heal...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.837741/full |
| _version_ | 1819156938929209344 |
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| author | Evelyn Xiu Ling Loo Evelyn Xiu Ling Loo Evelyn Xiu Ling Loo Delicia Shu Qin Ooi Minyee Ong Le Duc Huy Ta Hui Xing Lau Michelle Jia Yu Tay Qai Ven Yap Yiong Huak Chan Elizabeth Huiwen Tham Elizabeth Huiwen Tham Elizabeth Huiwen Tham Elizabeth Huiwen Tham Anne Eng Neo Goh Hugo Van Bever Hugo Van Bever Oon Hoe Teoh Johan Gunnar Eriksson Johan Gunnar Eriksson Johan Gunnar Eriksson Johan Gunnar Eriksson Yap Seng Chong Yap Seng Chong Peter Gluckman Peter Gluckman Fabian Kok Peng Yap Fabian Kok Peng Yap Fabian Kok Peng Yap Neerja Karnani Neerja Karnani Neerja Karnani Jia Xu Karen Mei Ling Tan Kok Hian Tan Bee Wah Lee Michael Kramer Michael Kramer Lynette Pei-chi Shek Lynette Pei-chi Shek Michael J. Meaney Michael J. Meaney Michael J. Meaney Michael J. Meaney Birit F. P. Broekman Birit F. P. Broekman |
| author_facet | Evelyn Xiu Ling Loo Evelyn Xiu Ling Loo Evelyn Xiu Ling Loo Delicia Shu Qin Ooi Minyee Ong Le Duc Huy Ta Hui Xing Lau Michelle Jia Yu Tay Qai Ven Yap Yiong Huak Chan Elizabeth Huiwen Tham Elizabeth Huiwen Tham Elizabeth Huiwen Tham Elizabeth Huiwen Tham Anne Eng Neo Goh Hugo Van Bever Hugo Van Bever Oon Hoe Teoh Johan Gunnar Eriksson Johan Gunnar Eriksson Johan Gunnar Eriksson Johan Gunnar Eriksson Yap Seng Chong Yap Seng Chong Peter Gluckman Peter Gluckman Fabian Kok Peng Yap Fabian Kok Peng Yap Fabian Kok Peng Yap Neerja Karnani Neerja Karnani Neerja Karnani Jia Xu Karen Mei Ling Tan Kok Hian Tan Bee Wah Lee Michael Kramer Michael Kramer Lynette Pei-chi Shek Lynette Pei-chi Shek Michael J. Meaney Michael J. Meaney Michael J. Meaney Michael J. Meaney Birit F. P. Broekman Birit F. P. Broekman |
| author_sort | Evelyn Xiu Ling Loo |
| collection | DOAJ |
| description | BackgroundEpidemiological studies suggest a link between eczema and attention deficit hyperactivity disorder (ADHD), but underlying mechanisms have not been examined.ObjectiveWe aim to investigate the association between eczema and subsequent ADHD symptoms in the Growing Up in Singapore Towards healthy Outcomes cohort and explore the role of pro-inflammatory cytokines and gut microbiome.MethodsThe modified International Study of Asthma and Allergies in Childhood questionnaire and Computerized Diagnostic Interview Schedule for Children Version IV were administered to assess reported eczema within the first 18 months and presence of ADHD symptoms at 54 months, respectively. Skin prick testing at 18 months, cytokines in maternal blood during pregnancy and cord blood and the mediating role of the gut microbiome at 24 months were assessed.ResultsAfter adjusting for confounders, eczema with or without a positive skin prick test was associated with doubling the risk of ADHD symptoms. No differences in maternal and cord blood cytokines were observed in children with and without eczema, or children with and without ADHD. Gut microbiome dysbiosis was observed in children with eczema and children with ADHD. Children with eczema also had lower gut bacterial Shannon diversity. However, the relationship between eczema and ADHD was not mediated by gut microbiome.ConclusionEarly life eczema diagnosis is associated with a higher risk of subsequent ADHD symptoms in children. We found no evidence for underlying inflammatory mechanism or mediation by gut microbiome dysbiosis. Further research should evaluate other mechanisms underlying the link between eczema and ADHD.Clinical Trial Registration[https://clinicaltrials.gov/ct2/show/NCT01174875], identifier [NCT01174875]. |
| first_indexed | 2024-12-22T16:00:50Z |
| format | Article |
| id | doaj.art-ab0c43f8279b4356ba4ffd3738d5c6e1 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-22T16:00:50Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-ab0c43f8279b4356ba4ffd3738d5c6e12022-12-21T18:20:42ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-03-011010.3389/fped.2022.837741837741Associations Between Eczema and Attention Deficit Hyperactivity Disorder Symptoms in ChildrenEvelyn Xiu Ling Loo0Evelyn Xiu Ling Loo1Evelyn Xiu Ling Loo2Delicia Shu Qin Ooi3Minyee Ong4Le Duc Huy Ta5Hui Xing Lau6Michelle Jia Yu Tay7Qai Ven Yap8Yiong Huak Chan9Elizabeth Huiwen Tham10Elizabeth Huiwen Tham11Elizabeth Huiwen Tham12Elizabeth Huiwen Tham13Anne Eng Neo Goh14Hugo Van Bever15Hugo Van Bever16Oon Hoe Teoh17Johan Gunnar Eriksson18Johan Gunnar Eriksson19Johan Gunnar Eriksson20Johan Gunnar Eriksson21Yap Seng Chong22Yap Seng Chong23Peter Gluckman24Peter Gluckman25Fabian Kok Peng Yap26Fabian Kok Peng Yap27Fabian Kok Peng Yap28Neerja Karnani29Neerja Karnani30Neerja Karnani31Jia Xu32Karen Mei Ling Tan33Kok Hian Tan34Bee Wah Lee35Michael Kramer36Michael Kramer37Lynette Pei-chi Shek38Lynette Pei-chi Shek39Michael J. Meaney40Michael J. Meaney41Michael J. Meaney42Michael J. Meaney43Birit F. P. Broekman44Birit F. P. Broekman45Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, SingaporeDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeHuman Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, SingaporeDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, SingaporeDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeDepartment of Biostatistics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeDepartment of Biostatistics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, SingaporeDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeHuman Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeKhoo Teck Puat-National University Children’s Medical Institute, National University Hospital, National University Health System, Singapore, SingaporeAllergy Service, Department of Paediatrics, KK Women’s and Children’s Hospital, Singapore, SingaporeDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeKhoo Teck Puat-National University Children’s Medical Institute, National University Hospital, National University Health System, Singapore, SingaporeRespiratory Service, Department of Paediatrics, KK Women’s and Children’s Hospital, Singapore, SingaporeSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, SingaporeHuman Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeDepartment of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, SingaporeFolkhälsan Research Center, Faculty of Medicine, University of Helsinki, Helsinki, FinlandSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, SingaporeDepartment of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, SingaporeSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore1Liggins Institute, University of Auckland, Auckland, New Zealand2Duke-NUS Medical School, Singapore, Singapore3Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore4Endocrinology Service, Department of Paediatrics, KK Women’s and Children’s Hospital, Singapore, SingaporeSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore5Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore6Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, SingaporeSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, SingaporeSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore7Department of Maternal Fetal Medicine, KK Women’s and Children’s Hospital, Singapore, SingaporeDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeDepartment of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore8Department of Pediatrics and of Epidemiology and Biostatistics, McGill University Faculty of Medicine, Montreal, QC, CanadaDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeKhoo Teck Puat-National University Children’s Medical Institute, National University Hospital, National University Health System, Singapore, SingaporeSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore9Sackler Program for Epigenetics & Psychobiology at McGill University, Montreal, QC, Canada0Ludmer Centre for Neuroinformatics and Mental Health, McGill University, Montreal, QC, Canada1Department of Psychiatry, McGill University, Montreal, QC, CanadaSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore2Department of Psychiatry, OLVG and Amsterdam UMC, VU University, Amsterdam, NetherlandsBackgroundEpidemiological studies suggest a link between eczema and attention deficit hyperactivity disorder (ADHD), but underlying mechanisms have not been examined.ObjectiveWe aim to investigate the association between eczema and subsequent ADHD symptoms in the Growing Up in Singapore Towards healthy Outcomes cohort and explore the role of pro-inflammatory cytokines and gut microbiome.MethodsThe modified International Study of Asthma and Allergies in Childhood questionnaire and Computerized Diagnostic Interview Schedule for Children Version IV were administered to assess reported eczema within the first 18 months and presence of ADHD symptoms at 54 months, respectively. Skin prick testing at 18 months, cytokines in maternal blood during pregnancy and cord blood and the mediating role of the gut microbiome at 24 months were assessed.ResultsAfter adjusting for confounders, eczema with or without a positive skin prick test was associated with doubling the risk of ADHD symptoms. No differences in maternal and cord blood cytokines were observed in children with and without eczema, or children with and without ADHD. Gut microbiome dysbiosis was observed in children with eczema and children with ADHD. Children with eczema also had lower gut bacterial Shannon diversity. However, the relationship between eczema and ADHD was not mediated by gut microbiome.ConclusionEarly life eczema diagnosis is associated with a higher risk of subsequent ADHD symptoms in children. We found no evidence for underlying inflammatory mechanism or mediation by gut microbiome dysbiosis. Further research should evaluate other mechanisms underlying the link between eczema and ADHD.Clinical Trial Registration[https://clinicaltrials.gov/ct2/show/NCT01174875], identifier [NCT01174875].https://www.frontiersin.org/articles/10.3389/fped.2022.837741/fullatopyattention deficit hyperactivity disordercytokineseczemagut microbiome dysbiosis |
| spellingShingle | Evelyn Xiu Ling Loo Evelyn Xiu Ling Loo Evelyn Xiu Ling Loo Delicia Shu Qin Ooi Minyee Ong Le Duc Huy Ta Hui Xing Lau Michelle Jia Yu Tay Qai Ven Yap Yiong Huak Chan Elizabeth Huiwen Tham Elizabeth Huiwen Tham Elizabeth Huiwen Tham Elizabeth Huiwen Tham Anne Eng Neo Goh Hugo Van Bever Hugo Van Bever Oon Hoe Teoh Johan Gunnar Eriksson Johan Gunnar Eriksson Johan Gunnar Eriksson Johan Gunnar Eriksson Yap Seng Chong Yap Seng Chong Peter Gluckman Peter Gluckman Fabian Kok Peng Yap Fabian Kok Peng Yap Fabian Kok Peng Yap Neerja Karnani Neerja Karnani Neerja Karnani Jia Xu Karen Mei Ling Tan Kok Hian Tan Bee Wah Lee Michael Kramer Michael Kramer Lynette Pei-chi Shek Lynette Pei-chi Shek Michael J. Meaney Michael J. Meaney Michael J. Meaney Michael J. Meaney Birit F. P. Broekman Birit F. P. Broekman Associations Between Eczema and Attention Deficit Hyperactivity Disorder Symptoms in Children Frontiers in Pediatrics atopy attention deficit hyperactivity disorder cytokines eczema gut microbiome dysbiosis |
| title | Associations Between Eczema and Attention Deficit Hyperactivity Disorder Symptoms in Children |
| title_full | Associations Between Eczema and Attention Deficit Hyperactivity Disorder Symptoms in Children |
| title_fullStr | Associations Between Eczema and Attention Deficit Hyperactivity Disorder Symptoms in Children |
| title_full_unstemmed | Associations Between Eczema and Attention Deficit Hyperactivity Disorder Symptoms in Children |
| title_short | Associations Between Eczema and Attention Deficit Hyperactivity Disorder Symptoms in Children |
| title_sort | associations between eczema and attention deficit hyperactivity disorder symptoms in children |
| topic | atopy attention deficit hyperactivity disorder cytokines eczema gut microbiome dysbiosis |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.837741/full |
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