Optimal Dose of Vitamin D For Covid-19 Treatment
Highlights: • Vitamin D supplementations in different doses yield different outcomes. • Multi-day vitamin D administration of 1000-6000 IU in patients with COVID-19 has more positive impacts than a single high dose of vitamin D. • Patient morbidity, length of hospitalization, and patient mortali...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universitas Airlangga
2022-12-01
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| Series: | Folia Medica Indonesiana |
| Subjects: | |
| Online Access: | https://e-journal.unair.ac.id/FMI/article/view/36474 |
| _version_ | 1797954184072396800 |
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| author | Dita Mega Utami Muhammad Abdurrahman Rasyid Ash-Siddiq Desi Rianti Rahmahani Muhammad Iqbal Mubarok Muhammad Zulkifly Tasman Jeremy Nicolas Sibarani Habibah Teniya Ariq Fauziyah Budi Utomo Shifa Fauziyah |
| author_facet | Dita Mega Utami Muhammad Abdurrahman Rasyid Ash-Siddiq Desi Rianti Rahmahani Muhammad Iqbal Mubarok Muhammad Zulkifly Tasman Jeremy Nicolas Sibarani Habibah Teniya Ariq Fauziyah Budi Utomo Shifa Fauziyah |
| author_sort | Dita Mega Utami |
| collection | DOAJ |
| description | Highlights:
• Vitamin D supplementations in different doses yield different outcomes.
• Multi-day vitamin D administration of 1000-6000 IU in patients with COVID-19 has more positive impacts than a single high dose of vitamin D.
• Patient morbidity, length of hospitalization, and patient mortality improved with multi-day vitamin D administration.
Abstract:
This meta-analysis aimed to determine whether there is any optimal dose of vitamin D for morbidity, length of hospitalization, and mortality in patients with COVID-19. We conducted a comprehensive search in three online databases for eligible studies until February 28, 2022. Odds ratio (OR) and standardized mean difference (SMD) were applied as summary statistics of primary outcomes. The study quality of the literatures collected was assesed using the Cochrane risk of bias tool version 2 (RoB 2). Eight randomized clinical trials (RCT) were included in the study. In our analysis, we found that there was no significant difference in morbidity when vitamin D was administered to COVID-19 patients [OR=0.50 (95% CI=0.13-1.96); SMD=-0.14 (95% CI=-0.55-0.28)]. Duration of hospitalization [SMD=-0.12 (95% CI=-0.39-0.15)] and mortality [OR 0.47 (95% CI=0.19-1.17)] of COVID-19 patients in five studies also showed no significant difference compared to patients who do not take vitamin D. However, when we analyzed two other studies, we found that in patients who did not take vitamin D, mortality was lower [SMD=0.43 (95% CI=0.29, 0.58)]. Compared to a single high dose of vitamin D, the multi-day vitamin D administration of 1000-6000 IU in patients with COVID-19 resulted in improved patient morbidity, length of hospitalization, and patient mortality. |
| first_indexed | 2024-04-10T23:13:36Z |
| format | Article |
| id | doaj.art-ab0d2061204144359802a11e935066b0 |
| institution | Directory Open Access Journal |
| issn | 2355-8393 2599-056X |
| language | English |
| last_indexed | 2024-04-10T23:13:36Z |
| publishDate | 2022-12-01 |
| publisher | Universitas Airlangga |
| record_format | Article |
| series | Folia Medica Indonesiana |
| spelling | doaj.art-ab0d2061204144359802a11e935066b02023-01-13T03:24:34ZengUniversitas AirlanggaFolia Medica Indonesiana2355-83932599-056X2022-12-0158438339210.20473/fmi.v58i4.3647434515Optimal Dose of Vitamin D For Covid-19 TreatmentDita Mega Utami0https://orcid.org/0000-0002-8806-0934Muhammad Abdurrahman Rasyid Ash-Siddiq1https://orcid.org/0000-0002-8669-8280Desi Rianti Rahmahani2https://orcid.org/0000-0003-4351-8996Muhammad Iqbal Mubarok3https://orcid.org/0000-0003-0154-2103Muhammad Zulkifly Tasman4https://orcid.org/0000-0003-4623-5342Jeremy Nicolas Sibarani5Habibah Teniya Ariq Fauziyah6https://orcid.org/0000-0003-3992-9290Budi Utomo7https://orcid.org/0000-0002-1147-3263Shifa Fauziyah8https://orcid.org/0000-0002-2928-2967Medical Program, Faculty of Medicine, Universitas Airlangga, IndonesiaMedical Program, Faculty of Medicine, Universitas Airlangga, IndonesiaMedical Program, Faculty of Medicine, Universitas Airlangga, IndonesiaMedical Program, Faculty of Medicine, Universitas Airlangga, IndonesiaMedical Program, Faculty of Medicine, Universitas Airlangga, IndonesiaMedical Program, Faculty of Medicine, Universitas Airlangga, IndonesiaMedical Program, Faculty of Medicine, Universitas Airlangga, IndonesiaDepartment of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, IndonesiaDelima Husada Academy of Health Analyst, Gresik, East Java, IndonesiaHighlights: • Vitamin D supplementations in different doses yield different outcomes. • Multi-day vitamin D administration of 1000-6000 IU in patients with COVID-19 has more positive impacts than a single high dose of vitamin D. • Patient morbidity, length of hospitalization, and patient mortality improved with multi-day vitamin D administration. Abstract: This meta-analysis aimed to determine whether there is any optimal dose of vitamin D for morbidity, length of hospitalization, and mortality in patients with COVID-19. We conducted a comprehensive search in three online databases for eligible studies until February 28, 2022. Odds ratio (OR) and standardized mean difference (SMD) were applied as summary statistics of primary outcomes. The study quality of the literatures collected was assesed using the Cochrane risk of bias tool version 2 (RoB 2). Eight randomized clinical trials (RCT) were included in the study. In our analysis, we found that there was no significant difference in morbidity when vitamin D was administered to COVID-19 patients [OR=0.50 (95% CI=0.13-1.96); SMD=-0.14 (95% CI=-0.55-0.28)]. Duration of hospitalization [SMD=-0.12 (95% CI=-0.39-0.15)] and mortality [OR 0.47 (95% CI=0.19-1.17)] of COVID-19 patients in five studies also showed no significant difference compared to patients who do not take vitamin D. However, when we analyzed two other studies, we found that in patients who did not take vitamin D, mortality was lower [SMD=0.43 (95% CI=0.29, 0.58)]. Compared to a single high dose of vitamin D, the multi-day vitamin D administration of 1000-6000 IU in patients with COVID-19 resulted in improved patient morbidity, length of hospitalization, and patient mortality.https://e-journal.unair.ac.id/FMI/article/view/36474vitamin d therapycovid-19morbiditymortalityhospitalizationinfectious disease |
| spellingShingle | Dita Mega Utami Muhammad Abdurrahman Rasyid Ash-Siddiq Desi Rianti Rahmahani Muhammad Iqbal Mubarok Muhammad Zulkifly Tasman Jeremy Nicolas Sibarani Habibah Teniya Ariq Fauziyah Budi Utomo Shifa Fauziyah Optimal Dose of Vitamin D For Covid-19 Treatment Folia Medica Indonesiana vitamin d therapy covid-19 morbidity mortality hospitalization infectious disease |
| title | Optimal Dose of Vitamin D For Covid-19 Treatment |
| title_full | Optimal Dose of Vitamin D For Covid-19 Treatment |
| title_fullStr | Optimal Dose of Vitamin D For Covid-19 Treatment |
| title_full_unstemmed | Optimal Dose of Vitamin D For Covid-19 Treatment |
| title_short | Optimal Dose of Vitamin D For Covid-19 Treatment |
| title_sort | optimal dose of vitamin d for covid 19 treatment |
| topic | vitamin d therapy covid-19 morbidity mortality hospitalization infectious disease |
| url | https://e-journal.unair.ac.id/FMI/article/view/36474 |
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