Features and outcomes of malaria infection in glucose-6-phosphatedehydrogenase normal and deficient Nigerian children
<b>Background & objectives:</b> Malaria and G6PD deficiency-related haemolyses are known causes of hospital admissions in Nigeria and pose great danger to child survival but data on interactions of these two pathologies are scarce. This study was carried out to determine the associat...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Journal of Vector Borne Diseases |
| Subjects: | |
| Online Access: | http://www.mrcindia.org/journal/issues/511033.pdf |
| _version_ | 1818018281616834560 |
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| author | Adebola Emmanuel Orimadegun Olugbemiro Sodeinde |
| author_facet | Adebola Emmanuel Orimadegun Olugbemiro Sodeinde |
| author_sort | Adebola Emmanuel Orimadegun |
| collection | DOAJ |
| description | <b>Background & objectives:</b> Malaria and G6PD deficiency-related haemolyses are known causes of hospital admissions in Nigeria and pose great danger to child survival but data on interactions of these two pathologies are scarce. This study was carried out to determine the association between features of <i>Plasmodium falciparum</i> infection and G6PD status.
<b>Methods:</b> G6PD and haemoglobin were typed by fluorescent spot test and electrophoresis respectively, in 1120 children with microscopically-proven falciparum malaria. Clinical features of malaria were compared between G6PD normal and deficient children.
<b>Results:</b> There were 558 males and 562 females with median age of 35 months (range, 6 months-12 yr). In males, prevalence of G6PD-deficiency in patients with uncomplicated malaria (UM), severe malarial anaemia (SMA) and cerebral malaria (CM) was 23.4, 7 and 16.7%, respectively compared with 11.1, 7.3 and 4.4%, respectively among females. In both males and females, convulsion and rectal temperature above 38°C were less likely presentations among G6PD-deficient compared with G6PD-normal children (<i>p</i> <0.05). The proportions of children with pallor, convulsion and impaired consciousness were significantly lower among G6PD-deficient than normal males (<i>p</i> <0.05) but these features were not different between deficient and normal females (<i>p</i> >0.05).
<b>Interpretation & conclusion:</b> Convulsions, pallor and elevated temperature were more frequent features of malaria in G6PD normal than deficient children. G6PD-deficient male children are protected against impaired consciousness. These differences may offer useful hints in malaria treatment and researches in endemic regions. |
| first_indexed | 2024-04-14T07:37:01Z |
| format | Article |
| id | doaj.art-ab0d74b9a5e94aed9f60a1941b5abac5 |
| institution | Directory Open Access Journal |
| issn | 0972-9062 0972-9062 |
| language | English |
| last_indexed | 2024-04-14T07:37:01Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Vector Borne Diseases |
| spelling | doaj.art-ab0d74b9a5e94aed9f60a1941b5abac52022-12-22T02:05:39ZengWolters Kluwer Medknow PublicationsJournal of Vector Borne Diseases0972-90620972-90622014-01-015113339Features and outcomes of malaria infection in glucose-6-phosphatedehydrogenase normal and deficient Nigerian childrenAdebola Emmanuel OrimadegunOlugbemiro Sodeinde<b>Background & objectives:</b> Malaria and G6PD deficiency-related haemolyses are known causes of hospital admissions in Nigeria and pose great danger to child survival but data on interactions of these two pathologies are scarce. This study was carried out to determine the association between features of <i>Plasmodium falciparum</i> infection and G6PD status. <b>Methods:</b> G6PD and haemoglobin were typed by fluorescent spot test and electrophoresis respectively, in 1120 children with microscopically-proven falciparum malaria. Clinical features of malaria were compared between G6PD normal and deficient children. <b>Results:</b> There were 558 males and 562 females with median age of 35 months (range, 6 months-12 yr). In males, prevalence of G6PD-deficiency in patients with uncomplicated malaria (UM), severe malarial anaemia (SMA) and cerebral malaria (CM) was 23.4, 7 and 16.7%, respectively compared with 11.1, 7.3 and 4.4%, respectively among females. In both males and females, convulsion and rectal temperature above 38°C were less likely presentations among G6PD-deficient compared with G6PD-normal children (<i>p</i> <0.05). The proportions of children with pallor, convulsion and impaired consciousness were significantly lower among G6PD-deficient than normal males (<i>p</i> <0.05) but these features were not different between deficient and normal females (<i>p</i> >0.05). <b>Interpretation & conclusion:</b> Convulsions, pallor and elevated temperature were more frequent features of malaria in G6PD normal than deficient children. G6PD-deficient male children are protected against impaired consciousness. These differences may offer useful hints in malaria treatment and researches in endemic regions.http://www.mrcindia.org/journal/issues/511033.pdfClinical features; glucose-6-phosphate dehydrogenase; <i>Plasmodium falciparum</i> malaria |
| spellingShingle | Adebola Emmanuel Orimadegun Olugbemiro Sodeinde Features and outcomes of malaria infection in glucose-6-phosphatedehydrogenase normal and deficient Nigerian children Journal of Vector Borne Diseases Clinical features; glucose-6-phosphate dehydrogenase; <i>Plasmodium falciparum</i> malaria |
| title | Features and outcomes of malaria infection in glucose-6-phosphatedehydrogenase normal and deficient Nigerian children |
| title_full | Features and outcomes of malaria infection in glucose-6-phosphatedehydrogenase normal and deficient Nigerian children |
| title_fullStr | Features and outcomes of malaria infection in glucose-6-phosphatedehydrogenase normal and deficient Nigerian children |
| title_full_unstemmed | Features and outcomes of malaria infection in glucose-6-phosphatedehydrogenase normal and deficient Nigerian children |
| title_short | Features and outcomes of malaria infection in glucose-6-phosphatedehydrogenase normal and deficient Nigerian children |
| title_sort | features and outcomes of malaria infection in glucose 6 phosphatedehydrogenase normal and deficient nigerian children |
| topic | Clinical features; glucose-6-phosphate dehydrogenase; <i>Plasmodium falciparum</i> malaria |
| url | http://www.mrcindia.org/journal/issues/511033.pdf |
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