Impact of Obesity in Kidney Diseases
The clinical consequences of obesity on the kidneys, with or without metabolic abnormalities, involve both renal function and structures. The mechanisms linking obesity and renal damage are well understood, including several effector mechanisms with interconnected pathways. Higher prevalence of urin...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/13/12/4482 |
| _version_ | 1797501791602999296 |
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| author | Vasilios Kotsis Fernando Martinez Christina Trakatelli Josep Redon |
| author_facet | Vasilios Kotsis Fernando Martinez Christina Trakatelli Josep Redon |
| author_sort | Vasilios Kotsis |
| collection | DOAJ |
| description | The clinical consequences of obesity on the kidneys, with or without metabolic abnormalities, involve both renal function and structures. The mechanisms linking obesity and renal damage are well understood, including several effector mechanisms with interconnected pathways. Higher prevalence of urinary albumin excretion, sub-nephrotic syndrome, nephrolithiasis, increased risk of developing CKD, and progression to ESKD have been identified as being associated with obesity and having a relevant clinical impact. Moreover, renal replacement therapy and kidney transplantation are also influenced by obesity. Losing weight is key in limiting the impact that obesity produces on the kidneys by reducing albuminuria/proteinuria, declining rate of eGFR deterioration, delaying the development of CKD and ESKD, and improving the outcome of a renal transplant. Weight reduction may also contribute to appropriate control of cardiometabolic risk factors such as hypertension, metabolic syndrome, diabetes, and dyslipidemia which may be protective not only in renal damage but also cardiovascular disease. Lifestyle changes, some drugs, and bariatric surgery have demonstrated the benefits. |
| first_indexed | 2024-03-10T03:23:38Z |
| format | Article |
| id | doaj.art-ab0e865d27a74e07b9927c196a35e17b |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T03:23:38Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-ab0e865d27a74e07b9927c196a35e17b2023-11-23T09:58:19ZengMDPI AGNutrients2072-66432021-12-011312448210.3390/nu13124482Impact of Obesity in Kidney DiseasesVasilios Kotsis0Fernando Martinez1Christina Trakatelli2Josep Redon33rd Department of Internal Medicine, Hypertension-24h ABPM ESH Center of Excellence, Papageorgiou Hospital, Aristotle University of Thessaloniki, 564 29 Pavlos Melas, GreeceInternal Medicine Hospital Clínico de Valencia, 46010 Valencia, Spain3rd Department of Internal Medicine, Hypertension-24h ABPM ESH Center of Excellence, Papageorgiou Hospital, Aristotle University of Thessaloniki, 564 29 Pavlos Melas, GreeceInternal Medicine Hospital Clínico de Valencia, 46010 Valencia, SpainThe clinical consequences of obesity on the kidneys, with or without metabolic abnormalities, involve both renal function and structures. The mechanisms linking obesity and renal damage are well understood, including several effector mechanisms with interconnected pathways. Higher prevalence of urinary albumin excretion, sub-nephrotic syndrome, nephrolithiasis, increased risk of developing CKD, and progression to ESKD have been identified as being associated with obesity and having a relevant clinical impact. Moreover, renal replacement therapy and kidney transplantation are also influenced by obesity. Losing weight is key in limiting the impact that obesity produces on the kidneys by reducing albuminuria/proteinuria, declining rate of eGFR deterioration, delaying the development of CKD and ESKD, and improving the outcome of a renal transplant. Weight reduction may also contribute to appropriate control of cardiometabolic risk factors such as hypertension, metabolic syndrome, diabetes, and dyslipidemia which may be protective not only in renal damage but also cardiovascular disease. Lifestyle changes, some drugs, and bariatric surgery have demonstrated the benefits.https://www.mdpi.com/2072-6643/13/12/4482obesityfatty kidneyglomerulopathyCKDESRDbariatric surgery |
| spellingShingle | Vasilios Kotsis Fernando Martinez Christina Trakatelli Josep Redon Impact of Obesity in Kidney Diseases Nutrients obesity fatty kidney glomerulopathy CKD ESRD bariatric surgery |
| title | Impact of Obesity in Kidney Diseases |
| title_full | Impact of Obesity in Kidney Diseases |
| title_fullStr | Impact of Obesity in Kidney Diseases |
| title_full_unstemmed | Impact of Obesity in Kidney Diseases |
| title_short | Impact of Obesity in Kidney Diseases |
| title_sort | impact of obesity in kidney diseases |
| topic | obesity fatty kidney glomerulopathy CKD ESRD bariatric surgery |
| url | https://www.mdpi.com/2072-6643/13/12/4482 |
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