Immunogenic cell death as driver of autoimmunity in granulomatosis with polyangiitis

Immunogenic cell death as driver of autoimmunity in granulomatosis with polyangiitis

Cell death and dysregulated clearance of dead cells play essential roles in the induction of chronic inflammatory processes and autoimmune diseases. Granulomatosis with polyangiitis (GPA), a neutrophil-driven autoimmune disorder, is characterized by necrotizing inflammation predominantly of the resp...

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Bibliographic Details
Main Authors: Christoph Brieske, Peter Lamprecht, Anja Kerstein-Staehle
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
immunogenic cell death
autoimmunity
neutrophils
vasculitis
granulomatosis with polyangiitis
damage-associated molecular pattern (DAMP)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1007092/full

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