Targeting Trypanothione Reductase, a Key Enzyme in the Redox Trypanosomatid Metabolism, to Develop New Drugs against Leishmaniasis and Trypanosomiases

Targeting Trypanothione Reductase, a Key Enzyme in the Redox Trypanosomatid Metabolism, to Develop New Drugs against Leishmaniasis and Trypanosomiases

The protozoans <i>Leishmania</i> and <i>Trypanosoma</i>, belonging to the same Trypanosomatidae family, are the causative agents of Leishmaniasis, Chagas disease, and human African trypanosomiasis. Overall, these infections affect millions of people worldwide, posing a seriou...

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Bibliographic Details
Main Authors: Theo Battista, Gianni Colotti, Andrea Ilari, Annarita Fiorillo
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Molecules
Subjects:
trypanosomatid infection
structure-based drug design
trypanothione reductase
rational drug discovery
protein crystallography
Online Access:https://www.mdpi.com/1420-3049/25/8/1924

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