Unraveling the importance of molecules of natural origin in antifungal drug development through targeting ergosterol biosynthesis pathway
Over the past decades, the incidence of life-threatening fungal infections has increased dramatically in particular among patients with hampered immune function. Fungal infections cause around 1.5 million deaths annually, superior to malaria and tuberculosis. With respect to high toxicity, narrow sp...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2020-01-01
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| Series: | Iranian Journal of Microbiology |
| Subjects: | |
| Online Access: | https://ijm.tums.ac.ir/index.php/ijm/article/view/2231 |
| _version_ | 1830308752799039488 |
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| author | Fatemehsadat Jamzivar Masoomeh Shams-Ghahfarokhi Mansoor Khoramizadeh Niloufar Yousefi Mohammadhassan Gholami-Shabani Mehdi Razzaghi-Abyaneh |
| author_facet | Fatemehsadat Jamzivar Masoomeh Shams-Ghahfarokhi Mansoor Khoramizadeh Niloufar Yousefi Mohammadhassan Gholami-Shabani Mehdi Razzaghi-Abyaneh |
| author_sort | Fatemehsadat Jamzivar |
| collection | DOAJ |
| description | Over the past decades, the incidence of life-threatening fungal infections has increased dramatically in particular among patients with hampered immune function. Fungal infections cause around 1.5 million deaths annually, superior to malaria and tuberculosis. With respect to high toxicity, narrow spectrum of activity and drug resistance to current antifungals, there is an urgent need to discover novel leads from molecules of natural origin especially those derived from plants and microorganisms for antifungal drug discovery. Among antifungal drugs introduced into the clinic, those affecting ergosterol biosynthesis are still superior to other classes and the vital role of ergosterol in fungal growth and development. This review highlights current knowledge about available antifungal agents and further issues on antifungal drug discovery from compounds of natural origin which affect ergosterol biosynthesis. Special attention is made to the fungal sterol C24-methyltransferase (SMT), a crucial enzyme in ergosterol biosynthesis pathway as a novel target for rational drug design. |
| first_indexed | 2024-12-19T10:55:41Z |
| format | Article |
| id | doaj.art-ab13f37a9ab947608f03f17ec6841dcd |
| institution | Directory Open Access Journal |
| issn | 2008-3289 2008-4447 |
| language | English |
| last_indexed | 2024-12-19T10:55:41Z |
| publishDate | 2020-01-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Microbiology |
| spelling | doaj.art-ab13f37a9ab947608f03f17ec6841dcd2022-12-21T20:24:50ZengTehran University of Medical SciencesIranian Journal of Microbiology2008-32892008-44472020-01-0111610.18502/ijm.v11i6.2216Unraveling the importance of molecules of natural origin in antifungal drug development through targeting ergosterol biosynthesis pathwayFatemehsadat Jamzivar0Masoomeh Shams-Ghahfarokhi1Mansoor Khoramizadeh2Niloufar Yousefi3Mohammadhassan Gholami-Shabani4Mehdi Razzaghi-Abyaneh5Department of Mycology, Pasteur Institute of Iran, Tehran, IranDepartment of Mycology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IranSchool of Iranian Traditional Medicine, Iran University of Medical Sciences, Tehran, IranDepartment of Mycology, Pasteur Institute of Iran, Tehran, IranDepartment of Mycology, Pasteur Institute of Iran, Tehran, IranDepartment of Mycology, Pasteur Institute of Iran, Tehran, IranOver the past decades, the incidence of life-threatening fungal infections has increased dramatically in particular among patients with hampered immune function. Fungal infections cause around 1.5 million deaths annually, superior to malaria and tuberculosis. With respect to high toxicity, narrow spectrum of activity and drug resistance to current antifungals, there is an urgent need to discover novel leads from molecules of natural origin especially those derived from plants and microorganisms for antifungal drug discovery. Among antifungal drugs introduced into the clinic, those affecting ergosterol biosynthesis are still superior to other classes and the vital role of ergosterol in fungal growth and development. This review highlights current knowledge about available antifungal agents and further issues on antifungal drug discovery from compounds of natural origin which affect ergosterol biosynthesis. Special attention is made to the fungal sterol C24-methyltransferase (SMT), a crucial enzyme in ergosterol biosynthesis pathway as a novel target for rational drug design.https://ijm.tums.ac.ir/index.php/ijm/article/view/2231Ergosterol biosynthesis; Antifungal drug discovery; Natural compounds; Fungal infections |
| spellingShingle | Fatemehsadat Jamzivar Masoomeh Shams-Ghahfarokhi Mansoor Khoramizadeh Niloufar Yousefi Mohammadhassan Gholami-Shabani Mehdi Razzaghi-Abyaneh Unraveling the importance of molecules of natural origin in antifungal drug development through targeting ergosterol biosynthesis pathway Iranian Journal of Microbiology Ergosterol biosynthesis; Antifungal drug discovery; Natural compounds; Fungal infections |
| title | Unraveling the importance of molecules of natural origin in antifungal drug development through targeting ergosterol biosynthesis pathway |
| title_full | Unraveling the importance of molecules of natural origin in antifungal drug development through targeting ergosterol biosynthesis pathway |
| title_fullStr | Unraveling the importance of molecules of natural origin in antifungal drug development through targeting ergosterol biosynthesis pathway |
| title_full_unstemmed | Unraveling the importance of molecules of natural origin in antifungal drug development through targeting ergosterol biosynthesis pathway |
| title_short | Unraveling the importance of molecules of natural origin in antifungal drug development through targeting ergosterol biosynthesis pathway |
| title_sort | unraveling the importance of molecules of natural origin in antifungal drug development through targeting ergosterol biosynthesis pathway |
| topic | Ergosterol biosynthesis; Antifungal drug discovery; Natural compounds; Fungal infections |
| url | https://ijm.tums.ac.ir/index.php/ijm/article/view/2231 |
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