The Role of MYCN in Symmetric vs. Asymmetric Cell Division of Human Neuroblastoma Cells
Asymmetric cell division (ACD) is an important physiological event in the development of various organisms and maintenance of tissue homeostasis. ACD produces two different cells in a single cell division: a stem/progenitor cell and differentiated cell. Although the balance between self-renewal and...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.570815/full |
| _version_ | 1818906736851943424 |
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| author | Hideki Izumi Yasuhiko Kaneko Akira Nakagawara |
| author_facet | Hideki Izumi Yasuhiko Kaneko Akira Nakagawara |
| author_sort | Hideki Izumi |
| collection | DOAJ |
| description | Asymmetric cell division (ACD) is an important physiological event in the development of various organisms and maintenance of tissue homeostasis. ACD produces two different cells in a single cell division: a stem/progenitor cell and differentiated cell. Although the balance between self-renewal and differentiation is precisely controlled, disruptions to ACD and/or enhancements in the self-renewal division (symmetric cell division: SCD) of stem cells resulted in the formation of tumors in Drosophila neuroblasts. ACD is now regarded as one of the characteristics of human cancer stem cells, and is a driving force for cancer cell heterogeneity. We recently reported that MYCN controls the balance between SCD and ACD in human neuroblastoma cells. In this mini-review, we discuss the mechanisms underlying MYCN-mediated cell division fate. |
| first_indexed | 2024-12-19T21:43:54Z |
| format | Article |
| id | doaj.art-ab155ba6cddd40438aedba65d5f28366 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-19T21:43:54Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-ab155ba6cddd40438aedba65d5f283662022-12-21T20:04:34ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-10-011010.3389/fonc.2020.570815570815The Role of MYCN in Symmetric vs. Asymmetric Cell Division of Human Neuroblastoma CellsHideki Izumi0Yasuhiko Kaneko1Akira Nakagawara2Laboratory of Molecular Medicine, Life Sciences Institute, Saga-Ken Medical Centre Koseikan, Saga, JapanResearch Institute for Clinical Oncology, Saitama Cancer Center, Saitama, JapanSAGA HIMAT, Tosu, JapanAsymmetric cell division (ACD) is an important physiological event in the development of various organisms and maintenance of tissue homeostasis. ACD produces two different cells in a single cell division: a stem/progenitor cell and differentiated cell. Although the balance between self-renewal and differentiation is precisely controlled, disruptions to ACD and/or enhancements in the self-renewal division (symmetric cell division: SCD) of stem cells resulted in the formation of tumors in Drosophila neuroblasts. ACD is now regarded as one of the characteristics of human cancer stem cells, and is a driving force for cancer cell heterogeneity. We recently reported that MYCN controls the balance between SCD and ACD in human neuroblastoma cells. In this mini-review, we discuss the mechanisms underlying MYCN-mediated cell division fate.https://www.frontiersin.org/articles/10.3389/fonc.2020.570815/fullMYCNTRIM32NCYMALDH18A1asymmetric cell divisionneuroblastoma |
| spellingShingle | Hideki Izumi Yasuhiko Kaneko Akira Nakagawara The Role of MYCN in Symmetric vs. Asymmetric Cell Division of Human Neuroblastoma Cells Frontiers in Oncology MYCN TRIM32 NCYM ALDH18A1 asymmetric cell division neuroblastoma |
| title | The Role of MYCN in Symmetric vs. Asymmetric Cell Division of Human Neuroblastoma Cells |
| title_full | The Role of MYCN in Symmetric vs. Asymmetric Cell Division of Human Neuroblastoma Cells |
| title_fullStr | The Role of MYCN in Symmetric vs. Asymmetric Cell Division of Human Neuroblastoma Cells |
| title_full_unstemmed | The Role of MYCN in Symmetric vs. Asymmetric Cell Division of Human Neuroblastoma Cells |
| title_short | The Role of MYCN in Symmetric vs. Asymmetric Cell Division of Human Neuroblastoma Cells |
| title_sort | role of mycn in symmetric vs asymmetric cell division of human neuroblastoma cells |
| topic | MYCN TRIM32 NCYM ALDH18A1 asymmetric cell division neuroblastoma |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2020.570815/full |
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