Structural characterization of protective non-neutralizing antibodies targeting Crimean-Congo hemorrhagic fever virus
There are currently no approved treatments for Crimean-Congo Hemorrhagic Fever Virus (CCHFV) infection. In this study, the authors structurally characterize the epitope targeted by protective non-neutralizing mouse and human antibodies and provide insights into their broad range potential against va...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34923-0 |
| _version_ | 1811187022413430784 |
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| author | Ian A. Durie Zahra R. Tehrani Elif Karaaslan Teresa E. Sorvillo Jack McGuire Joseph W. Golden Stephen R. Welch Markus H. Kainulainen Jessica R. Harmon Jarrod J. Mousa David Gonzalez Suzanne Enos Iftihar Koksal Gurdal Yilmaz Hanife Nur Karakoc Sanaz Hamidi Cansu Albay Jessica R. Spengler Christina F. Spiropoulou Aura R. Garrison Mohammad M. Sajadi Éric Bergeron Scott D. Pegan |
| author_facet | Ian A. Durie Zahra R. Tehrani Elif Karaaslan Teresa E. Sorvillo Jack McGuire Joseph W. Golden Stephen R. Welch Markus H. Kainulainen Jessica R. Harmon Jarrod J. Mousa David Gonzalez Suzanne Enos Iftihar Koksal Gurdal Yilmaz Hanife Nur Karakoc Sanaz Hamidi Cansu Albay Jessica R. Spengler Christina F. Spiropoulou Aura R. Garrison Mohammad M. Sajadi Éric Bergeron Scott D. Pegan |
| author_sort | Ian A. Durie |
| collection | DOAJ |
| description | There are currently no approved treatments for Crimean-Congo Hemorrhagic Fever Virus (CCHFV) infection. In this study, the authors structurally characterize the epitope targeted by protective non-neutralizing mouse and human antibodies and provide insights into their broad range potential against various CCHFV strains. |
| first_indexed | 2024-04-11T13:55:13Z |
| format | Article |
| id | doaj.art-ab186bd397154dcabe6fc31995264ac7 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T13:55:13Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ab186bd397154dcabe6fc31995264ac72022-12-22T04:20:22ZengNature PortfolioNature Communications2041-17232022-11-0113111210.1038/s41467-022-34923-0Structural characterization of protective non-neutralizing antibodies targeting Crimean-Congo hemorrhagic fever virusIan A. Durie0Zahra R. Tehrani1Elif Karaaslan2Teresa E. Sorvillo3Jack McGuire4Joseph W. Golden5Stephen R. Welch6Markus H. Kainulainen7Jessica R. Harmon8Jarrod J. Mousa9David Gonzalez10Suzanne Enos11Iftihar Koksal12Gurdal Yilmaz13Hanife Nur Karakoc14Sanaz Hamidi15Cansu Albay16Jessica R. Spengler17Christina F. Spiropoulou18Aura R. Garrison19Mohammad M. Sajadi20Éric Bergeron21Scott D. Pegan22Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of GeorgiaDivision of Clinical Care and Research, Institute of Human Virology, University of Maryland School of MedicineViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and PreventionViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and PreventionDivision of Biomedical Sciences, University of California RiversideVirology Division, United States Army Medical Research Institute of Infectious DiseasesViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and PreventionViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and PreventionViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and PreventionDepartment of Infectious Diseases, University of Georgia College of Veterinary MedicineDivision of Biomedical Sciences, University of California RiversideDepartment of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of GeorgiaDepartment of Infectious Disease and Clinical Microbiology, Acibadem University Atakent HospitalDepartment of Infectious Diseases, Karadeniz Technical University School of MedicineDepartment of Infectious Disease and Clinical Microbiology, Bitlis State HospitalDepartment of Infectious Diseases, Karadeniz Technical University School of MedicineDepartment of Infectious Diseases, Karadeniz Technical University School of MedicineViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and PreventionViral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and PreventionVirology Division, United States Army Medical Research Institute of Infectious DiseasesDivision of Clinical Care and Research, Institute of Human Virology, University of Maryland School of MedicineDepartment of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of GeorgiaDivision of Biomedical Sciences, University of California RiversideThere are currently no approved treatments for Crimean-Congo Hemorrhagic Fever Virus (CCHFV) infection. In this study, the authors structurally characterize the epitope targeted by protective non-neutralizing mouse and human antibodies and provide insights into their broad range potential against various CCHFV strains.https://doi.org/10.1038/s41467-022-34923-0 |
| spellingShingle | Ian A. Durie Zahra R. Tehrani Elif Karaaslan Teresa E. Sorvillo Jack McGuire Joseph W. Golden Stephen R. Welch Markus H. Kainulainen Jessica R. Harmon Jarrod J. Mousa David Gonzalez Suzanne Enos Iftihar Koksal Gurdal Yilmaz Hanife Nur Karakoc Sanaz Hamidi Cansu Albay Jessica R. Spengler Christina F. Spiropoulou Aura R. Garrison Mohammad M. Sajadi Éric Bergeron Scott D. Pegan Structural characterization of protective non-neutralizing antibodies targeting Crimean-Congo hemorrhagic fever virus Nature Communications |
| title | Structural characterization of protective non-neutralizing antibodies targeting Crimean-Congo hemorrhagic fever virus |
| title_full | Structural characterization of protective non-neutralizing antibodies targeting Crimean-Congo hemorrhagic fever virus |
| title_fullStr | Structural characterization of protective non-neutralizing antibodies targeting Crimean-Congo hemorrhagic fever virus |
| title_full_unstemmed | Structural characterization of protective non-neutralizing antibodies targeting Crimean-Congo hemorrhagic fever virus |
| title_short | Structural characterization of protective non-neutralizing antibodies targeting Crimean-Congo hemorrhagic fever virus |
| title_sort | structural characterization of protective non neutralizing antibodies targeting crimean congo hemorrhagic fever virus |
| url | https://doi.org/10.1038/s41467-022-34923-0 |
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